Imperial College London
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ProfessorDavidSharp

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology
 
 
 
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Contact

 

+44 (0)20 7594 7991david.sharp Website

 
 
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Location

 

UREN.927Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ibitoye:2022:10.1016/j.nicl.2022.103098,
author = {Ibitoye, RT and Castro, P and Cooke, J and Allum, J and Arshad, Q and Murdin, L and Wardlaw, J and Kaski, D and Sharp, DJ and Bronstein, AM},
doi = {10.1016/j.nicl.2022.103098},
journal = {NeuroImage: Clinical},
pages = {1--12},
title = {A link between frontal white matter integrity and dizziness in cerebral small vessel disease},
url = {http://dx.doi.org/10.1016/j.nicl.2022.103098},
volume = {35},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance.
AU  - Ibitoye,RT
AU  - Castro,P
AU  - Cooke,J
AU  - Allum,J
AU  - Arshad,Q
AU  - Murdin,L
AU  - Wardlaw,J
AU  - Kaski,D
AU  - Sharp,DJ
AU  - Bronstein,AM
DO  - 10.1016/j.nicl.2022.103098
EP  - 12
PY  - 2022///
SN  - 2213-1582
SP  - 1
TI  - A link between frontal white matter integrity and dizziness in cerebral small vessel disease
T2  - NeuroImage: Clinical
UR  - http://dx.doi.org/10.1016/j.nicl.2022.103098
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000828145400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S2213158222001632?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101883
VL  - 35
ER  -
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