Imperial College London
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ProfessorDavidSharp

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology
 
 
 
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Contact

 

+44 (0)20 7594 7991david.sharp Website

 
 
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Location

 

UREN.927Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jenkins:2018:brain/awx357,
author = {Jenkins, PO and De, Simoni S and Bourke, N and Fleminger, J and Scott, G and Towey, D and Svensson, W and Khan, S and Patel, M and Greenwood, R and Cole, J and Sharp, DJ},
doi = {brain/awx357},
journal = {Brain},
pages = {797--810},
title = {Dopaminergic abnormalities following traumatic brain injury},
url = {http://dx.doi.org/10.1093/brain/awx357},
volume = {141},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Traumatic brain injury can reduce striatal dopamine levels. The cause of this is uncertain, but is likely to be related to damage to the nigrostriatal system. We investigated the pattern of striatal dopamine abnormalities using 123I-Ioflupane single-photon emission computed tomography (SPECT) scans and their relationship to nigrostriatal damage and clinical features. We studied 42 moderate–severe traumatic brain injury patients with cognitive impairments but no motor parkinsonism signs and 20 healthy controls. 123I-Ioflupane scanning was used to assess dopamine transporter levels. Clinical scan reports were compared to quantitative dopamine transporter results. Advanced MRI methods were used to assess the nigrostriatal system, including the area through which the nigrostriatal projections pass as defined from high-resolution Human Connectome data. Detailed clinical and neuropsychological assessments were performed. Around 20% of our moderate–severe patients had clear evidence of reduced specific binding ratios for the dopamine transporter in the striatum measured using 123I-Ioflupane SPECT. The caudate was affected more consistently than other striatal regions. Dopamine transporter abnormalities were associated with reduced substantia nigra volume. In addition, diffusion MRI provided evidence of damage to the regions through which the nigrostriatal tract passes, particularly the area traversed by dopaminergic projections to the caudate. Only a small percentage of patients had evidence of macroscopic lesions in the striatum and there was no relationship between presence of lesions and dopamine transporter specific binding ratio abnormalities. There was also no relationship between reduced volume in the striatal subregions and reduced dopamine transporter specific binding ratios. Patients with low caudate dopamine transporter specific binding ratios show impaired processing speed and executive dysfunction compared to patients with normal levels. Taken toge
AU  - Jenkins,PO
AU  - De,Simoni S
AU  - Bourke,N
AU  - Fleminger,J
AU  - Scott,G
AU  - Towey,D
AU  - Svensson,W
AU  - Khan,S
AU  - Patel,M
AU  - Greenwood,R
AU  - Cole,J
AU  - Sharp,DJ
DO  - brain/awx357
EP  - 810
PY  - 2018///
SN  - 1460-2156
SP  - 797
TI  - Dopaminergic abnormalities following traumatic brain injury
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/awx357
UR  - http://hdl.handle.net/10044/1/53452
VL  - 141
ER  -
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