Summary
I am a graduate of the Cambridge MB/PhD programme. Originally studying immune tolerance breakdown in type 1 diabetes with Anne Cooke for my PhD, I then worked as a Clinical Lecturer with Ken Smith and Gordon Dougan FRS. During this time, I characterised the novel protein EROS. Having demonstrated that EROS was essential for the generation of reactive oxygen species by the innate immune system, I was awarded a Wellcome Trust Clinical Research Career Development Fellowship and the Beit Prize in 2017. In April 2019, I moved my laboratory to Imperial College to take up a Readership. My laboratory works on (i) how Eros controls the phagocyte respiratory burst and other processes in innate and adaptive immunity as well as (ii) the role of reactive oxygen species, derived from a variety of sources, in immunity more generally. My clinical work is as a nephrologist and internal physician and I am a Consultant Nephrologist at the Hammersmith Hospital, predominantly focused on the care of renal transplant patients.
Selected Publications
Journal Articles
Willicombe M, Gleeson S, Clarke C, et al., 2021, Identification of Patient Characteristics Associated With SARS-CoV-2 Infection and Outcome in Kidney Transplant Patients Using Serological Screening, Transplantation, Vol:105, ISSN:0041-1337, Pages:151-157
Canton J, Blees H, Henry CM, et al., 2020, The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens, Nature Immunology, Vol:22, ISSN:1529-2908, Pages:140-U56
Gisby J, Clarke C, Medjeral-Thomas N, et al., 2020, Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease, Elife, Vol:10, ISSN:2050-084X, Pages:1-30
Bashford-Rogers RJM, Bergamaschi L, McKinney EF, et al., 2019, Analysis of the B cell receptor repertoire in six immune-mediated diseases, Nature, Vol:574, ISSN:0028-0836, Pages:122-126
Thomas DC, Charbonnier L-M, Schejtman A, et al., 2019, EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease, Journal of Allergy and Clinical Immunology, Vol:143, ISSN:0091-6749, Pages:782-785.e1
Sowerby JM, Thomas DC, Clare S, et al., 2017, NBEAL2 is required for neutrophil and NK cell function and pathogen defense, Journal of Clinical Investigation, Vol:127, ISSN:0021-9738, Pages:3259-3264
Thomas DC, Clare S, Sowerby JM, et al., 2017, Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1111-1128