DrDavidThomas

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology and Inflammation (Clinical)

Contact

Location

9NCCommonwealth BuildingHammersmith Campus

Summary

I am a graduate of the Cambridge MB/PhD programme. Originally studying immune tolerance breakdown in type 1 diabetes with Anne Cooke for my PhD, I then worked as a Clinical Lecturer with Ken Smith and Gordon Dougan FRS. During this time, I characterised the novel protein EROS. Having demonstrated that EROS was essential for the generation of reactive oxygen species by the innate immune system, I was awarded a Wellcome Trust Clinical Research Career Development Fellowship and the Beit Prize in 2017. In April 2019, I moved my laboratory to Imperial College to take up a Readership. My laboratory works on (i) how Eros controls the phagocyte respiratory burst and other processes in innate and adaptive immunity as well as (ii) the role of reactive oxygen species, derived from a variety of sources, in immunity more generally. My clinical work is as a nephrologist and internal physician and I am a Consultant Nephrologist at the Hammersmith Hospital, predominantly focused on the care of renal transplant patients.

Selected Publications

Journal Articles

Gisby J, Buang N, Papadaki A, et al.Gisby J, Buang N, Papadaki A, Clarke C, Malik T, Medjeral-Thomas N, Pinheiro D, Mortimer P, Lewis S, Sandhu E, McAdoo S, Prendecki M, Willicombe M, Pickering M, Botto M, Thomas DC, Peters J close, 2022, Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence, Nature Communications, Vol:13, ISSN:2041-1723

Randzavola LO, Mortimer PM, Garside E, et al.Randzavola LO, Mortimer PM, Garside E, Dufficy ER, Schejtman A, Roumelioti G, Yu L, Pardo M, Spirohn K, Tolley C, Brandt C, Harcourt K, Nichols E, Nahorski M, Woods G, Williamson JC, Suresh S, Sowerby JM, Matsumoto M, Santos CXC, Kiar CS, Mukhopadhyay S, Rae WM, Dougan GJ, Grainger J, Lehner PJ, Calderwood MA, Choudhary J, Clare S, Speak A, Santilli G, Bateman A, Smith KGC, Magnani F, Thomas DC close, 2022, EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling, Elife, Vol:11, ISSN:2050-084X

Rae W, Sowerby JM, Verhoeven D, et al.Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Mendoza SCS, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Reyes SOL, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC close, 2022, Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations, Science Immunology, Vol:7, ISSN:2470-9468

Canton J, Blees H, Henry CM, et al.Canton J, Blees H, Henry CM, Buck MD, Schulz O, Rogers NC, Childs E, Zelenay S, Rhys H, Domart M-C, Collinson L, Alloatti A, Ellison CJ, Amigorena S, Papayannopoulos V, Thomas DC, Randow F, Reis e Sousa C close, 2020, The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens, Nature Immunology, Vol:22, ISSN:1529-2908, Pages:140-U56

Gisby J, Clarke C, Medjeral-Thomas N, et al.Gisby J, Clarke C, Medjeral-Thomas N, Malik T, Papadaki A, Mortimer P, Buang N, Lewis S, Pereira M, Toulza F, Fagnano E, Mawhin M-A, Dutton E, Tapeng L, Kirk P, Behmoaras J, Sandhu E, McAdoo S, Prendecki M, Pickering M, Botto M, Willicombe M, Thomas D, Peters J close, 2020, Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease, Elife, Vol:10, ISSN:2050-084X, Pages:1-30

Bashford-Rogers RJM, Bergamaschi L, McKinney EF, et al.Bashford-Rogers RJM, Bergamaschi L, McKinney EF, Pombal DC, Mescia F, Lee JC, Thomas DC, Flint SM, Kellam P, Jayne DRW, Lyons PA, Smith KGC close, 2019, Analysis of the B cell receptor repertoire in six immune-mediated diseases, Nature, Vol:574, ISSN:0028-0836, Pages:122-126

Thomas DC, Charbonnier L-M, Schejtman A, et al.Thomas DC, Charbonnier L-M, Schejtman A, Aldhekri H, Coomber EL, Dufficy ER, Beenken AE, Lee JC, Clare S, Speak AO, Thrasher AJ, Santilli G, Al-Mousa H, Alkuraya FS, Chatila TA, Smith KGC close, 2019, EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease, Journal of Allergy and Clinical Immunology, Vol:143, ISSN:0091-6749, Pages:782-785.e1

Sowerby JM, Thomas DC, Clare S, et al.Sowerby JM, Thomas DC, Clare S, Espeli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KGC close, 2017, NBEAL2 is required for neutrophil and NK cell function and pathogen defense, Journal of Clinical Investigation, Vol:127, ISSN:0021-9738, Pages:3259-3264

Thomas DC, Clare S, Sowerby JM, et al.Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espeli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KGC close, 2017, Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1111-1128

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