7 results found
Llinares-López F, Papaxanthos L, Roqueiro D, et al., 2019, CASMAP: detection of statistically significant combinations of SNPs in association mapping, Bioinformatics, Vol: 35, Pages: 2680-2682, ISSN: 1367-4803
Combinatorial association mapping aims to assess the statistical association of higher-order interactions of genetic markers with a phenotype of interest. This article presents combinatorial association mapping (CASMAP), a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Most importantly, unlike other existing significant pattern mining-based tools, CASMAP allows for the correction of categorical covariates such as age or gender, making it suitable for genome-wide association studies.
Bodenham DA, Adams NM, 2017, Continuous monitoring for changepoints in data streams using adaptive estimation, Statistics and Computing, Vol: 27, Pages: 1257-1270, ISSN: 0960-3174
Data streams are characterised by a potentially unending sequence of high-frequency observations which are subject to unknown temporal variation. Many modern streaming applications demand the capability to sequentially detect changes as soon as possible after they occur, while continuing to monitor the stream as it evolves. We refer to this problem as continuous monitoring. Sequential algorithms such as CUSUM, EWMA and their more sophisticated variants usually require a pair of parameters to be selected for practical application. However, the choice of parameter values is often based on the anticipated size of the changes and a given choice is unlikely to be optimal for the multiple change sizes which are likely to occur in a streaming data context. To address this critical issue, we introduce a changepoint detection framework based on adaptive forgetting factors that, instead of multiple control parameters, only requires a single parameter to be selected. Simulated results demonstrate that this framework has utility in a continuous monitoring setting. In particular, it reduces the burden of selecting parameters in advance. Moreover, the methodology is demonstrated on real data arising from Foreign Exchange markets.
Llinares-López F, Papaxanthos L, Bodenham D, et al., 2017, Genome-wide genetic heterogeneity discovery with categorical covariates, Bioinformatics, Vol: 33, Pages: 1820-1828, ISSN: 1367-4803
MotivationGenetic heterogeneity is the phenomenon that distinct genetic variants may give rise to the same phenotype. The recently introduced algorithm Fast Automatic Interval Search (FAIS) enables the genome-wide search of candidate regions for genetic heterogeneity in the form of any contiguous sequence of variants, and achieves high computational efficiency and statistical power. Although FAIS can test all possible genomic regions for association with a phenotype, a key limitation is its inability to correct for confounders such as gender or population structure, which may lead to numerous false-positive associations.ResultsWe propose FastCMH, a method that overcomes this problem by properly accounting for categorical confounders, while still retaining statistical power and computational efficiency. Experiments comparing FastCMH with FAIS and multiple kinds of burden tests on simulated data, as well as on human and Arabidopsis samples, demonstrate that FastCMH can drastically reduce genomic inflation and discover associations that are missed by standard burden tests.Availability and ImplementationAn R package fastcmh is available on CRAN and the source code can be found at: https://www.bsse.ethz.ch/mlcb/research/bioinformatics-and-computational-biology/fastcmh.html
Llinares-López F, Grimm DG, Bodenham DA, et al., 2015, Genome-wide detection of intervals of genetic heterogeneity associated with complex traits, Publisher: Oxford University Press (OUP), Pages: i240-i249, ISSN: 1367-4803
Adams NM, Bodenham DA, 2015, A comparison of efficient approximations for a weighted sum of chi-squared random variables, Statistics and Computing, Vol: 26, Pages: 917-928, ISSN: 0960-3174
In many applications, the cumulative distribution function (cdf) FQNFQN of a positively weighted sum of N i.i.d. chi-squared random variables QNQN is required. Although there is no known closed-form solution for FQNFQN, there are many good approximations. When computational efficiency is not an issue, Imhof’s method provides a good solution. However, when both the accuracy of the approximation and the speed of its computation are a concern, there is no clear preferred choice. Previous comparisons between approximate methods could be considered insufficient. Furthermore, in streaming data applications where the computation needs to be both sequential and efficient, only a few of the available methods may be suitable. Streaming data problems are becoming ubiquitous and provide the motivation for this paper. We develop a framework to enable a much more extensive comparison between approximate methods for computing the cdf of weighted sums of an arbitrary random variable. Utilising this framework, a new and comprehensive analysis of four efficient approximate methods for computing FQNFQN is performed. This analysis procedure is much more thorough and statistically valid than previous approaches described in the literature. A surprising result of this analysis is that the accuracy of these approximate methods increases with N.
Bodenham DA, Adams NM, 2014, Adaptive change detection for relay-like behaviour, IEEE Joint Intelligence and Security Informatics Conference (JISIC 2014), Publisher: IEEE, Pages: 252-255
Bodenham DA, Adams NM, 2013, Continuous monitoring of a computer network using multivariate adaptive estimation, IEEE 13th International Conference on Data Mining (ICDM), Publisher: IEEE, Pages: 311-318, ISSN: 2375-9232
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.