Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Reader in Imaging Sciences



+44 (0)20 3313 1510declan.oregan




Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus






Dr Declan O'Regan is an MRC Senior Clinician Scientist and Consultant Radiologist who heads the Robert Steiner MRI suite (Mansfield Centre for Innovation) on the Hammersmith Hospital campus and is lead clinician for Imaging Research at Imperial College Healthcare NHS Trust.

His main research interest is mathematical modelling of the heart using human MR imaging to understand the genetic and physiological mechanisms that underpin cardiovascular disease. His projects include:

  • Developing high-resolution MRI techniques for capturing cardiac structure and motion in three-dimensions.
  • Applying segmentation algorithms to create a three-dimensional statistical representation of cardiovascular phenotypic variation.
  • Modelling the effects of blood pressure and body composition on cardiac structure.
  • Automated survival prediction using computational models of heart failure.
  • Discovery of genotype-phenotype associations using whole-organ models.
  • Evaluating the effect of rare variants on the cardiovascular phenotype.
  • Optimising clinical decision making using Bayesian networks
  • Using exercise cardiac MRI as a predictor of outcomes in pulmonary hypertension and discovering the effects of normobaric hypoxia on cardiac function.

His interdisciplinary collaborators include Prof Stuart Cook, Prof Daniel Rueckert, and Prof Ewan Birney. This research is funded by NIHR, BHF and MRC.  

 Cardiac MR Images

Selected Publications

Journal Articles

Attard M, Dawes T, Simoes Monteiro de Marvao A, et al., Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: three dimensional analysis of cardiac magnetic resonance, Ehj Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging, ISSN:2047-2412

Ware JS, Amor-Salamanca A, Tayal U, et al., 2018, Genetic Etiology for Alcohol-Induced Cardiac Toxicity, Journal of the American College of Cardiology, Vol:71, ISSN:0735-1097, Pages:2293-2302

Dawes TJW, Cai J, Quinlan M, et al., 2018, Fractal Analysis of Right Ventricular Trabeculae in Pulmonary Hypertension, Radiology, Vol:288, ISSN:0033-8419, Pages:386-395

Michelakis ED, Gurtu V, Webster L, et al., 2017, Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients, Science Translational Medicine, Vol:9, ISSN:1946-6234

Biffi C, de Marvao A, Attard MI, et al., 2018, Three-dimensional cardiovascular imaging-genetics: a mass univariate framework, Bioinformatics, Vol:34, ISSN:1367-4803, Pages:97-103

Schafer S, de Marvao A, Adami E, et al., 2017, Titin-truncating variants affect heart function in disease cohorts and the general population, Nature Genetics, Vol:49, ISSN:1061-4036, Pages:46-53

Dawes TJW, de Marvao A, Shi W, et al., 2017, Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study, Radiology, Vol:283, ISSN:0033-8419, Pages:381-390

Dawes TJW, Corden B, Cotter S, et al., 2016, Moderate Physical Activity in Healthy Adults Is Associated With Cardiac Remodeling, Circulation-Cardiovascular Imaging, Vol:9, ISSN:1941-9651

O'Regan DP, 2016, Stiff Arteries, Stiff Ventricles Correlation or Causality in Heart Failure?, Circulation-Cardiovascular Imaging, Vol:9, ISSN:1941-9651

Dawes TJW, Gandhi A, de Marvao A, et al., 2016, Pulmonary Artery Stiffness Is Independently Associated with Right Ventricular Mass and Function: A Cardiac MR Imaging Study, Radiology, Vol:280, ISSN:0033-8419, Pages:398-404

de Marvao A, Dawes TJW, Shi W, et al., 2015, Precursors of Hypertensive Heart Phenotype Develop in Healthy Adults A High-Resolution 3D MRI Study, JACC-Cardiovascular Imaging, Vol:8, ISSN:1936-878X, Pages:1260-1269

Roberts AM, Ware JS, Herman DS, et al., 2015, Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease, Science Translational Medicine, Vol:7, ISSN:1946-6234

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