Dr Declan O'Regan is an MRC Clinical Scientist and Consultant Radiologist who heads the Robert Steiner MRI suite (Mansfield Centre for Innovation) at the MRC London Institute of Medical Sciences. He is lead clinician for imaging research at Imperial College Healthcare NHS Trust. He is committed to science engagement and is a past Roentgen (UK) and Rowan-Williams (Australasia) travelling professor.
His research is focussed on developing artificial intelligence to understand the genetic and physiological mechanisms that underpin cardiovascular disease using cardiac imaging. His team recently developed the 4Dsurvival algorithm for predicting outcomes in heart disease from cardiac motion analysis (Nature Machine Intelligence). His projects include:
- Developing advanced computer vision algorithms in cardiac MRI.
- Predicting time-to-events from cardiac motion analysis.
- Automated discovery of cardiac genotype-phenotype associations in health and disease.
- Designing artificial reasoning systems to classify heart disease.
- Accelerating drug discovery using machine learning in UK Biobank.
- Discovering new quantitative imaging risk factors in heart disease.
His interdisciplinary collaborators include Prof Stuart Cook, Prof Daniel Rueckert, and Prof Ewan Birney. This research is funded by NIHR, BHF and MRC.
et al., 2019, Deep learning cardiac motion analysis for human survival prediction, Nature Machine Intelligence, Vol:1, ISSN:2522-5839, Pages:95-104
et al., 2018, Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: Three dimensional analysis of cardiac magnetic resonance imaging, Ehj Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging, ISSN:2047-2412
et al., 2018, Fractal analysis of right ventricular trabeculae in pulmonary hypertension, Radiology, Vol:288, ISSN:0033-8419, Pages:386-395
et al., 2018, A genetic etiology for alcohol-induced cardiac toxicity, Journal of the American College of Cardiology, Vol:71, ISSN:0735-1097, Pages:2293-2302
et al., 2017, Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients, Science Translational Medicine, Vol:9, ISSN:1946-6234
et al., 2017, Three-dimensional Cardiovascular Imaging-Genetics: A Mass Univariate Framework, Bioinformatics, ISSN:1367-4803
et al., 2017, Machine learning of three-dimensional right ventricular motion enables outcome prediction in pulmonary hypertension: a cardiac MR imaging study, Radiology, Vol:283, ISSN:1527-1315, Pages:381-390
et al., 2016, Titin truncating variants affect heart function in disease cohorts and the general population, Nature Genetics, Vol:49, ISSN:1546-1718, Pages:46-53
et al., 2016, Moderate Physical Activity in Healthy Adults is Associated with Cardiac Remodeling, Circulation-cardiovascular Imaging, Vol:9, ISSN:1942-0080
et al., 2016, Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac magnetic resonance study., Radiology, Vol:280, ISSN:1527-1315