Imperial College London

DrDeclanO'Regan

Faculty of MedicineInstitute of Clinical Sciences

Reader in Imaging Sciences
 
 
 
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Contact

 

+44 (0)20 3313 1510declan.oregan

 
 
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Location

 

Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shirvani:2019:10.1007/s00330-018-5628-3,
author = {Shirvani, S and Tokarczuk, P and Statton, B and Quinlan, M and Berry, A and Tomlinson, J and Weale, P and Kuhn, B and O'Regan, DP},
doi = {10.1007/s00330-018-5628-3},
journal = {European Radiology},
pages = {232--240},
title = {Motion-corrected multiparametric renal arterial spin labelling at 3T: Reproducibility and effect of vasodilator challenge},
url = {http://dx.doi.org/10.1007/s00330-018-5628-3},
volume = {29},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - ObjectivesWe investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1.MethodsIn a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots.ResultsInter-study correlation of whole-kidney RBF was good for both single-TI (r2 = 0.90), and multi-TI ASL (r2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant.ConclusionsFree-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge.
AU - Shirvani,S
AU - Tokarczuk,P
AU - Statton,B
AU - Quinlan,M
AU - Berry,A
AU - Tomlinson,J
AU - Weale,P
AU - Kuhn,B
AU - O'Regan,DP
DO - 10.1007/s00330-018-5628-3
EP - 240
PY - 2019///
SN - 0938-7994
SP - 232
TI - Motion-corrected multiparametric renal arterial spin labelling at 3T: Reproducibility and effect of vasodilator challenge
T2 - European Radiology
UR - http://dx.doi.org/10.1007/s00330-018-5628-3
UR - https://link.springer.com/article/10.1007%2Fs00330-018-5628-3
UR - http://hdl.handle.net/10044/1/61596
VL - 29
ER -