Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Reader in Imaging Sciences



+44 (0)20 3313 1510declan.oregan




Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus






BibTex format

author = {Osimo, EF and Brugger, SP and de, Marvao A and Pillinger, T and Whitehurst, T and Statton, B and Quinlan, M and Berry, A and Cook, SA and O'Regan, DP and Howes, OD},
doi = {10.1101/19008649},
publisher = {Cold Spring Harbor Laboratory},
title = {Cardiac structure and function in schizophrenia: a cardiac MR imaging study},
url = {},
year = {2019}

RIS format (EndNote, RefMan)

AB - <jats:p>Background: Heart disease is the leading cause of death in schizophrenia. Aims: We investigated cardiac structure and function in patients with schizophrenia using cardiac magnetic resonance imaging (CMR) after excluding medical and metabolic comorbidity. Methods: 80 participants underwent CMR to determine biventricular volumes and function and measures of blood pressure, physical activity, and glycated haemoglobin levels. Patients and controls were matched for age, sex, ethnicity, and body surface area. Results: Patients with schizophrenia had significantly smaller indexed left ventricular (LV) end-diastolic volume, end-systolic volume, stroke volume, right ventricular (RV) end-diastolic volume, end-systolic volume, and stroke volume but unaltered ejection fractions relative to controls. LV concentricity and septal thickness were significantly larger in schizophrenia. The findings were largely unchanged after adjusting for smoking or exercise levels and were independent of medication dose and duration. Conclusions: Patients with schizophrenia show evidence of prognostically-adverse cardiac remodelling compared to matched controls, independent of conventional risk factors.</jats:p>
AU - Osimo,EF
AU - Brugger,SP
AU - de,Marvao A
AU - Pillinger,T
AU - Whitehurst,T
AU - Statton,B
AU - Quinlan,M
AU - Berry,A
AU - Cook,SA
AU - O'Regan,DP
AU - Howes,OD
DO - 10.1101/19008649
PB - Cold Spring Harbor Laboratory
PY - 2019///
TI - Cardiac structure and function in schizophrenia: a cardiac MR imaging study
UR -
ER -