Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Reader in Imaging Sciences



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Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus






BibTex format

author = {Dawes, T and Cai, J and Quinlan, M and Simoes, Monteiro de Marvao A and Ostowski, P and Tokarczuk, P and Watson, G and Wharton, J and Howard, L and Gibbs, J and Cook, S and Wilkins, M and O'Regan, DP},
doi = {10.1148/radiol.2018172821},
journal = {Radiology},
pages = {386--395},
title = {Fractal analysis of right ventricular trabeculae in pulmonary hypertension},
url = {},
volume = {288},
year = {2018}

RIS format (EndNote, RefMan)

AB - Purpose: To measure right ventricular (RV) trabecular complexity by its fractal dimension (FD) in healthy subjects and patients with pulmonary hypertension (PH) and assess its relationship to hemodynamic and functional parameters, and future cardiovascular events. Materials and methods: This retrospective study used data acquired from May 2004 to October 2013 for 256 patients with newly-diagnosed PH that underwent cardiac magnetic resonance (CMR) imaging, right heart catheterization and six-minute walk distance testing with a median follow-up of 4.0 years. 256 healthy controls underwent CMR only. Biventricular FD, volumes and function were assessed on short-axis cine images. Reproducibility was assessed by intraclass correlation coefficient, correlation between variables was assessed by Pearson’s correlation test, and mortality prediction compared by univariable and multivariable Cox regression analysis. Results: RV-FD reproducibility had an intraclass correlation coefficient of 0.97 (95% confidence interval [CI]: 0.96, 0.98).RV-FD was higher in PH patients than healthy subjects (median 1.310, inter-quartile range [IQR] 1.281-1.341 vs 1.264, 1.242-1.295, P<.001) with the greatest difference near the apex. RV-FD was associated with pulmonary vascular resistance (r=0.30, P<.001). In univariable Cox regression analysis, RV-FD was a significant predictor of death (hazards ratio [HR]: 1.256, CI: 1.011, 1.560, P=.04), but in a multivariable analysis did not predict survival independently of conventional parameters of RV remodeling (HR: 1.179, CI: 0.871, 1.596, P=0.29). Conclusion: Fractal analysis of RV trabecular complexity is a highly reproducible measure of remodeling in PH associated with afterload, although the gain in survival prediction over traditional markers is not significant.
AU - Dawes,T
AU - Cai,J
AU - Quinlan,M
AU - Simoes,Monteiro de Marvao A
AU - Ostowski,P
AU - Tokarczuk,P
AU - Watson,G
AU - Wharton,J
AU - Howard,L
AU - Gibbs,J
AU - Cook,S
AU - Wilkins,M
AU - O'Regan,DP
DO - 10.1148/radiol.2018172821
EP - 395
PY - 2018///
SN - 0033-8419
SP - 386
TI - Fractal analysis of right ventricular trabeculae in pulmonary hypertension
T2 - Radiology
UR -
UR -
VL - 288
ER -