Imperial College London
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ProfessorDeclanO'Regan

Faculty of Medicine, Institute of Clinical Sciences

Professor of Imaging Sciences
 
 
 
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Contact

 

+44 (0)20 3313 1510declan.oregan

 
 
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Location

 

Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Osimo:2020:10.1192/bjp.2019.268,
author = {Osimo, E and Brugger, S and De, Marvao A and Pillinger, T and Whitehurst, T and Statton, B and Quinlan, M and Berry, A and Cook, SA and O'Regan, D and Howes, OD},
doi = {10.1192/bjp.2019.268},
journal = {British Journal of Psychiatry},
pages = {450--457},
title = {Cardiac structure and function in schizophrenia: a cardiac MR imaging study},
url = {http://dx.doi.org/10.1192/bjp.2019.268},
volume = {217},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Heart disease is the leading cause of death in schizophrenia. However, there has been little research directly examining cardiac function in schizophrenia.Aims:We investigated cardiac structure and function in patients with schizophrenia using cardiac magnetic resonance imaging (CMR) after excluding medical and metabolic comorbidity. Methods:80 participants underwent CMR to determine biventricular volumes and function and measures of blood pressure, physical activity, and glycated haemoglobin levels. Patients and controls were matched for age, sex, ethnicity, and body surface area. Results:Patients with schizophrenia had significantly smaller indexed left ventricular (LV) end-diastolic volume (effect size, d=-0.82, p=0.001), LV end-systolic volume (d=-0.58, p=0.02), LV stroke volume (d=-0.85, p=0.001), right ventricular (RV) end-diastolic volume (d=-0.79, p=0.002), RV end-systolic volume (d=-0.58, p=0.02), and RV stroke volume (d=-0.87, p=0.001) but unaltered ejection fractions relative to controls. LV concentricity (d=0.73, p=0.003) and septal thickness (d=1.13, p<0.001) were significantly larger in schizophrenia. Mean concentricity in patients was above the reference range. The findings were largely unchanged after adjusting for smoking and/or exercise levels and were independent of medication dose and duration. Conclusions:Patients with schizophrenia show evidence of concentric cardiac remodelling compared to healthy controls of a similar age, sex, ethnicity, body surface area and blood pressure, and independent of smoking and activity levels. This could be contributing to the excess cardiovascular mortality observed in patients. Future studies should investigate the contribution of antipsychotic medication to these changes.
AU  - Osimo,E
AU  - Brugger,S
AU  - De,Marvao A
AU  - Pillinger,T
AU  - Whitehurst,T
AU  - Statton,B
AU  - Quinlan,M
AU  - Berry,A
AU  - Cook,SA
AU  - O'Regan,D
AU  - Howes,OD
DO  - 10.1192/bjp.2019.268
EP  - 457
PY  - 2020///
SN  - 0007-1250
SP  - 450
TI  - Cardiac structure and function in schizophrenia: a cardiac MR imaging study
T2  - British Journal of Psychiatry
UR  - http://dx.doi.org/10.1192/bjp.2019.268
UR  - https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/cardiac-structure-and-function-in-schizophrenia-cardiac-magnetic-resonance-imaging-study/9BCF022FDE7FB7A4F9EF81A604285EF6
UR  - http://hdl.handle.net/10044/1/75385
VL  - 217
ER  -
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