Imperial College London
Portrait Picture

ProfessorDeclanO'Regan

Faculty of Medicine, Institute of Clinical Sciences

Professor of Imaging Sciences
 
 
 
//

Contact

 

+44 (0)20 3313 1510declan.oregan

 
 
//

Location

 

Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Lee:2019:10.1016/j.bpj.2019.08.025,
author = {Lee, AWC and O'Regan, DP and Gould, J and Sidhu, B and Sieniewicz, B and Plank, G and Warriner, DR and Lamata, P and Rinaldi, CA and Niederer, SA},
doi = {10.1016/j.bpj.2019.08.025},
journal = {Biophysical Journal},
pages = {2375--2381},
title = {Sex-dependent QRS guidelines for cardiac resynchronization therapy using computer model predictions},
url = {http://dx.doi.org/10.1016/j.bpj.2019.08.025},
volume = {117},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiac resynchronization therapy (CRT) is an important treatment for heart failure. Low female enrollment in clinical trials means that current CRT guidelines may be biased toward males. However, females have higher response rates at lower QRS duration (QRSd) thresholds. Sex differences in the left ventricle (LV) size could provide an explanation for the improved female response at lower QRSd. We aimed to test if sex differences in CRT response at lower QRSd thresholds are explained by differences in LV size and hence predict sex-specific guidelines for CRT. We investigated the effect that LV size sex difference has on QRSd between male and females in 1093 healthy individuals and 50 CRT patients using electrophysiological computer models of the heart. Simulations on the healthy mean shape models show that LV size sex difference can account for 50–100% of the sex difference in baseline QRSd in healthy individuals. In the CRT patient cohort, model simulations predicted female-specific guidelines for CRT, which were 9–13 ms lower than current guidelines. Sex differences in the LV size are able to account for a significant proportion of the sex difference in QRSd and provide a mechanistic explanation for the sex difference in CRT response. Simulations accounting for the smaller LV size in female CRT patients predict 9–13 ms lower QRSd thresholds for female CRT guidelines.
AU  - Lee,AWC
AU  - O'Regan,DP
AU  - Gould,J
AU  - Sidhu,B
AU  - Sieniewicz,B
AU  - Plank,G
AU  - Warriner,DR
AU  - Lamata,P
AU  - Rinaldi,CA
AU  - Niederer,SA
DO  - 10.1016/j.bpj.2019.08.025
EP  - 2381
PY  - 2019///
SN  - 0006-3495
SP  - 2375
TI  - Sex-dependent QRS guidelines for cardiac resynchronization therapy using computer model predictions
T2  - Biophysical Journal
UR  - http://dx.doi.org/10.1016/j.bpj.2019.08.025
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503173400014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0006349519307428?via%3Dihub
UR  - http://hdl.handle.net/10044/1/75870
VL  - 117
ER  -
Download