Imperial College London
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ProfessorDeclanO'Regan

Faculty of Medicine, Institute of Clinical Sciences

Professor of Imaging Sciences
 
 
 
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Contact

 

+44 (0)20 3313 1510declan.oregan

 
 
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Location

 

Imaging Sciences DepartmentHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Osimo:2021:10.1038/s41398-021-01741-9,
author = {Osimo, E and Sweeney, M and De, Marvao A and Berry, A and Statton, B and Perry, BI and Pillinger, T and Whitehurst, T and Cook, S and ORegan, D and Thomas, EL and Howes, OD},
doi = {10.1038/s41398-021-01741-9},
journal = {Translational Psychiatry},
pages = {1--9},
title = {Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia.  A multimodal, case-control study},
url = {http://dx.doi.org/10.1038/s41398-021-01741-9},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiovascular diseases are the leading cause of death in schizophrenia. Patients with schizophrenia show evidence of concentric cardiac remodelling (CCR), defined as an increase in left-ventricular mass over end-diastolic volumes. CCR is a predictor of cardiac disease, but the molecular pathways leading to this in schizophrenia are unknown. We aimed to explore the relevance of hypertensive and non-hypertensive pathways to CCR and their potential molecular underpinnings in schizophrenia. In this multimodal case–control study, we collected cardiac and whole-body fat magnetic resonance imaging (MRI), clinical measures, and blood levels of several cardiometabolic biomarkers known to potentially cause CCR from individuals with schizophrenia, alongside healthy controls (HCs) matched for age, sex, ethnicity, and body surface area. Of the 50 participants, 34 (68%) were male. Participants with schizophrenia showed increases in cardiac concentricity (d = 0.71, 95% CI: 0.12, 1.30; p = 0.01), indicative of CCR, but showed no differences in overall content or regional distribution of adipose tissue compared to HCs. Despite the cardiac changes, participants with schizophrenia did not demonstrate activation of the hypertensive CCR pathway; however, they showed evidence of adipose dysfunction: adiponectin was reduced (d = −0.69, 95% CI: −1.28, −0.10; p = 0.02), with evidence of activation of downstream pathways, including hypertriglyceridemia, elevated C-reactive protein, fasting glucose, and alkaline phosphatase. In conclusion, people with schizophrenia showed adipose tissue dysfunction compared to body mass-matched HCs. The presence of non-hypertensive CCR and a dysmetabolic phenotype may contribute to excess cardiovascular risk in schizophrenia. If our results are confirmed, acting on this pathway could reduce cardiovascular risk and resultant life-years lost in people with schizophrenia.
AU  - Osimo,E
AU  - Sweeney,M
AU  - De,Marvao A
AU  - Berry,A
AU  - Statton,B
AU  - Perry,BI
AU  - Pillinger,T
AU  - Whitehurst,T
AU  - Cook,S
AU  - ORegan,D
AU  - Thomas,EL
AU  - Howes,OD
DO  - 10.1038/s41398-021-01741-9
EP  - 9
PY  - 2021///
SN  - 2158-3188
SP  - 1
TI  - Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia.  A multimodal, case-control study
T2  - Translational Psychiatry
UR  - http://dx.doi.org/10.1038/s41398-021-01741-9
UR  - https://www.nature.com/articles/s41398-021-01741-9
UR  - http://hdl.handle.net/10044/1/93050
VL  - 11
ER  -
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