Summary
BACKGROUND
I conducted my doctoral training at the University of Oxford as a Clarendon Scholar in the laboratory of Professor Shankar Srinivas. There I investigated how transcription factor ETS2 may act as either an oncogene or tumour suppressor, using a combination of single-cell RNA-sequencing, FACS, high resolution fixed and live imaging, ex vivo pharmacological culture, and in vivo CRISPR genetics.
I went on to pursue epigenetic research as a Postdoctoral Scientist in the laboratory of Professor Petra Hajkova at London Institute of Medical Sciences MRC. My project involved uncovering molecular triggers for mouse germ cell epigenetic reprogramming using low-input RNA sequencing, FACS, mass spectrometry, embryonic stem cell derivation and directed differentiation, mathematical modelling, and bioinformatic approaches.
Publications
Journals
Tao H, Zhu M, Lau K, et al. , 2019, Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1703-1703
Rowan CJ, Li W, Martirosyan H, et al. , 2018, Hedgehog-GLI signaling inFoxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling, Development, Vol:145, ISSN:0950-1991, Pages:dev159947-dev159947
Smeeton J, Dhir P, Hu D, et al. , 2016, Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8, Journal of the American Society of Nephrology, Vol:27, ISSN:1046-6673, Pages:1465-1477
Stewart K, Gaitan Y, Shafer MER, et al. , 2016, A point mutation in p190A RhoGAP affects ciliogenesis and leads to glomerulocystic kidney defects, Plos Genetics, Vol:12, ISSN:1553-7390, Pages:1-20
Blake J, Hu D, Cain JE, et al. , 2016, Urogenital development in Pallister–Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor, Human Molecular Genetics, Vol:25, ISSN:0964-6906, Pages:437-447