Summary
BACKGROUND
I conducted my doctoral training at the University of Oxford as a Clarendon Scholar in the laboratory of Professor Shankar Srinivas. There I investigated how transcription factor ETS2 may act as either an oncogene or tumour suppressor, using a combination of single-cell RNA-sequencing, FACS, high resolution fixed and live imaging, ex vivo pharmacological culture, and in vivo CRISPR genetics.
I went on to pursue epigenetic research as a Postdoctoral Scientist in the laboratory of Professor Petra Hajkova at London Institute of Medical Sciences MRC. My project involved uncovering molecular triggers for mouse germ cell epigenetic reprogramming using low-input RNA sequencing, FACS, mass spectrometry, embryonic stem cell derivation and directed differentiation, mathematical modelling, and bioinformatic approaches.
Publications
Journals
Tao H, Zhu M, Lau K, et al., 2019, Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1703-1703
Rowan CJ, Li W, Martirosyan H, et al., 2018, Hedgehog-GLI signaling inFoxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling, Development, Vol:145, ISSN:0950-1991, Pages:dev159947-dev159947
Smeeton J, Dhir P, Hu D, et al., 2016, Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8, Journal of the American Society of Nephrology, Vol:27, ISSN:1046-6673, Pages:1465-1477
Stewart K, Gaitan Y, Shafer MER, et al., 2016, A point mutation in p190A RhoGAP affects ciliogenesis and leads to glomerulocystic kidney defects, Plos Genetics, Vol:12, ISSN:1553-7390, Pages:1-20
Blake J, Hu D, Cain JE, et al., 2016, Urogenital development in Pallister–Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor, Human Molecular Genetics, Vol:25, ISSN:0964-6906, Pages:437-447