Imperial College London
Alternate

ProfessorDianaBilton

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)7801 067 057diana.bilton

 
 
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Location

 

Fulham RoadRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

318 results found

Pabary R, Singh C, Morales S, Bush A, Alshafi K, Bilton D, Alton EWFW, Smithyman A, Davies JCet al., 2012, ANTI-PSEUDOMONAL BACTERIOPHAGE COCKTAIL REDUCES INFLAMMATORY RESPONSES IN THE MURINE LUNG, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A50-A51, ISSN: 0040-6376

Conference paper

Baty N, MacNeill SJ, Cullinan P, Alton EWFW, Bilton D, Griesenbach Uet al., 2012, IS THERE A GENDER DIFFERENCE IN THE UK CF POPULATION?, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A59-A59, ISSN: 0040-6376

Conference paper

Doering G, Flume P, Heijerman H, Elborn JS, Angyalosi G, Assael B, Bell S, Bilton D, De Boeck K, Bush A, Campbell PW, Cattaneo A, Dembowsky K, Drevinek P, Dubois C, Eichler I, Elborn JS, Flume PA, Foweraker JE, Gallagher C, Gartner S, Geller DE, Goldman M, Goss CH, Gupta R, Heijerman HG, Henig N, Higgins M, Hjelte L, Hoiby N, Jongejan R, Knoch M, Konstan MW, Muhlebach MS, Nieuwenhuizen PW, Parkins MD, Pressler T, Quittner AL, Ratjen F, Ramsey BW, Smyth A, Thieroff-Ekerdt R, Tullis E, van der Ent CK, Vazquez C, Wainwright CEet al., 2012, Treatment of lung infection in patients with cystic fibrosis: Current and future strategies, JOURNAL OF CYSTIC FIBROSIS, Vol: 11, Pages: 461-479, ISSN: 1569-1993

Journal article

Coleman MC, Hennessy C, Bilton D, Wilson R, Loebinger MRet al., 2012, THE SHORT TERM VARIABILITY OF SPUTUM MICROBIOLOGY IN NON-CF BRONCHIECTASIS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A139-A139, ISSN: 0040-6376

Conference paper

Srivastava SA, Elkin SL, Bilton D, 2012, The Transition of Adolescents with Chronic Respiratory Illness to Adult Care, PAEDIATRIC RESPIRATORY REVIEWS, Vol: 13, Pages: 230-235, ISSN: 1526-0542

Journal article

Thorpe-beeston J, Madge S, Gyi K, Hodson M, Bilton Det al., 2012, The outcome of pregnanciesin women with cystic fibrosis - single centre experience 1998-2011, Bjog-An International Journal of Obstetrics and Gynaecology

Journal article

Muttardi K, orchard C, simmonds N, Gyi K, Bilton D, Dhasmana Det al., 2012, Burkholderia cepacia complex and limited cutaeneous vasculitis- 20 years experience at large adult CF cemtre., North American Cf conference, Florida

Poster

Banks A, Davies G, Agent P, Osman L, Bilton D, Hodson Met al., 2012, The use of high frequency chest wall oscillation during an acute infective pulmonary exacerbation of cystic fibrosis, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Bilton D, Aitken ML, Fox H, Charlton Bet al., 2012, PREDICTING SUSTAINED RESPONSE TO BRONCHITOL™ TREATMENT IN PATIENTS WITH CYSTIC FIBROSIS, Publisher: WILEY-BLACKWELL, Pages: 289-290, ISSN: 8755-6863

Conference paper

Bilton D, Aitken ML, Fox H, Charlton Bet al., 2012, IMPROVEMENTS IN LUNG FUNCTION IN <i>PSEUDOMONAS</i> COLONISED PATIENTS TREATED WITH INHALED DRY POWDER MANNITOL (BRONCHITOL™), Publisher: WILEY-BLACKWELL, Pages: 314-314, ISSN: 8755-6863

Conference paper

Pabary R, Singh C, Morales S, Bush A, Alshafi K, Bilton D, Alton EW, Smithyman A, Davies JCet al., 2012, ANTI-PSEUDOMONAL BACTERIOPHAGE COCKTAIL REDUCES INFLAMMATORY RESPONSE IN THE MURINE LUNG, PEDIATRIC PULMONOLOGY, Vol: 47, Pages: 343-343, ISSN: 8755-6863

Journal article

Goss CH, MacNeill SJ, Quinton H, Marshall BC, Elbert A, Knapp E, Petren K, Sewall A, Gunn E, Osmond J, Bilton Det al., 2012, CHILDREN AND YOUNG ADULTS IN THE US HAVE IMPROVED LUNG FUNCTION COMPARED TO THE UK, PEDIATRIC PULMONOLOGY, Vol: 47, Pages: 378-378, ISSN: 8755-6863

Journal article

Davies GA, Banks AE, Agent P, Osman LP, Bilton D, Hodson MEet al., 2012, THE USE OF HIGH FREQUENCY CHEST WALL OSCILLATION DURING AN ACUTE INFECTIVE PULMONARY EXACERBATION OF CYSTIC FIBROSIS, Publisher: WILEY-BLACKWELL, Pages: 366-366, ISSN: 8755-6863

Conference paper

Griesenbach U, Baty NJ, Cullinan P, Alton EW, Bilton D, MacNeill SJet al., 2012, GENDER DIFFERENCES IN THE UK CF POPULATION, PEDIATRIC PULMONOLOGY, Vol: 47, Pages: 385-385, ISSN: 8755-6863

Journal article

Flude LJ, Agent P, Bilton D, 2012, Chest Physiotherapy Techniques in Bronchiectasis, CLINICS IN CHEST MEDICINE, Vol: 33, Pages: 351-+, ISSN: 0272-5231

Journal article

Wieboldt J, Atallah L, Kelly JL, Shrikrishna D, Gyi KM, Lo B, Yang GZ, Bilton D, Polkey MI, Hopkinson NSet al., 2012, Effect of acute exacerbations on skeletal muscle strength and physical activity in cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 11, Pages: 209-215, ISSN: 1569-1993

Journal article

Hurt K, Bilton D, 2012, Inhaled mannitol for the treatment of cystic fibrosis, EXPERT REVIEW OF RESPIRATORY MEDICINE, Vol: 6, Pages: 19-26, ISSN: 1747-6348

Journal article

Hurt K, Bilton D, 2012, Cystic fibrosis, Medicine, Vol: 40, Pages: 273-276, ISSN: 1357-3039

Cystic fibrosis (CF) is the most common lethal genetic disease in the Caucasian population. Survival has improved dramatically with expected median survival in the UK now 41.4 years. In CF, a vicious cycle of mucus stasis, chronic inflammation and recurrent infection leads to respiratory failure and death in the majority of patients. CF is a multisystem disease with pancreatic exocrine insufficiency occurring in the majority of patients. Treatment involves airway clearance techniques, inhaled muco-active therapies and the prevention and control of respiratory infection. Pseudomonas aeruginosa is the most common respiratory pathogen. In 2011, a mutation-specific therapy (VX-770) demonstrated efficacy for the first time. A number of other similar compounds are in the pipeline. With these treatments we are potentially entering a new era of CF care in which we may expect even longer survival. © 2012 Elsevier Ltd. All rights reserved.

Journal article

Hurt K, Bilton D, 2012, Haemoptysis: diagnosis and treatment., Acute Med, Vol: 11, Pages: 39-45

Haemoptysis is a common symptom in clinical practice, which requires further investigation. Fortunately, massive haemoptysis only accounts for a small proportion of these episodes. It is a medical emergency that carries a high mortality rate. There are no agreed management guidelines. This review discusses proposed methods of resuscitation as well as outlining a diagnostic algorithm and discusses treatments including bronchial artery embolization, endobronchial therapy, surgery and medical therapies.

Journal article

Chowdhury F, Wildman MJ, Gunn E, Bilton Det al., 2011, CYSTIC FIBROSIS DEATHS IN USA AND UK: COMPARISONS OF REGISTRY AND ROUTINE DATA, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A163-A164, ISSN: 0040-6376

Conference paper

Cox MJ, Jones AL, Loebinger MR, Duff RM, Simmonds NJ, Davies JC, Wilson R, Alton EW, Cookson WOCM, Bilton D, Moffatt MFet al., 2011, MUCOIDY AND THE MICROBIOME: COMMUNITY COMPOSITION IN RELATION TO THE PRESENCE OF CULTURABLE, MUCOID <i>PSEUDOMONAS AERUGINOSA</i>, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0040-6376

Conference paper

Bilton D, Robinson P, Cooper P, Gallagher CG, Kolbe J, Fox H, Jaques A, Charlton Bet al., 2011, Inhaled dry powder mannitol in cystic fibrosis: an efficacy and safety study, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 1071-1080, ISSN: 0903-1936

Journal article

Garattini E, Bilton D, Cremona G, Hodson Met al., 2011, Adult cystic fibrosis care in the 21st century., Monaldi Arch Chest Dis, Vol: 75, Pages: 178-184, ISSN: 1122-0643

Cystic fibrosis (CF) is the most common autosomal recessive inherited disease of Caucasian populations. As a result of a variety of diagnostic and therapeutic strategies there has been a dramatic increase in the life expectancy of patients with CF in the last decades and 50% of patients are now adults. This review will focus on the disease in adults and the provision of appropriate care. The complex care required to improve the survival and quality of life in the adult patients can best be provided in a dedicated adult cystic fibrosis unit. These units currently exist in many European countries, but more are needed in Italy.

Journal article

Higton A, Collins S, Bilton D, 2011, Gastroesophageal reflux causing nutritional failure and vomiting in a teenager with cystic fibrosis and respiratory failure, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 104, Pages: S44-S48, ISSN: 0141-0768

Journal article

Adler AI, Shine B, Haworth C, Leelarathna L, Bilton Det al., 2011, Hyperglycemia and Death in Cystic Fibrosis-Related Diabetes, Diabetes Care, Vol: 34, Pages: 1577-1578, ISSN: 0149-5992

OBJECTIVE Diabetes is common in cystic fibrosis and increases the risk of death, yet the role of hyperglycemia remains unproven. An association between glycemia and mortality would provide compelling evidence to support glucose lowering in cystic fibrosis–related diabetes (CFRD).RESEARCH DESIGN AND METHODS Using the U.K. Cystic Fibrosis Registry, we analyzed longitudinal data from 2006 to 2009 in 520 individuals with diabetes. We tested the association between HbA1c and mortality.RESULTS During a median follow-up of 2 years, 36 patients died. The median value of HbA1c was higher in those who died (7.3%) than in those who did not (6.7%). An HbA1c value of ≥6.5% was associated with a threefold increased risk of death (hazard ratio 3.2 [95% CI 1.4–7.3]; P = 0.005) independent of potential confounders.CONCLUSIONS Hyperglycemia trebles the risk of death in patients with CFRD. These findings provide epidemiologic support for continued efforts to improve glycemic control.Diabetes frequently complicates cystic fibrosis. Cystic fibrosis–related diabetes (CFRD) has an incidence in teenagers of up to 6% per year and a prevalence in adults of >30% (1,2). Diabetes further elevates the already high mortality rates in cystic fibrosis (3–5). In individuals without cystic fibrosis, diabetes increases the risk of death, and in individuals with diabetes, hyperglycemia increases the risk of death (6,7). However, no study of CFRD using national data has investigated whether hyperglycemia, per se, increases the risk of death; likewise, no trial has tested whether controlling blood glucose prolongs survival. Proving an association between glycemia and mortality in cystic fibrosis would provide compelling observational evidence to inform clinical practice. Using the U.K. Cystic Fibrosis Registry, we performed longitudinal analyses to test the association between glycemia, as measured by HbA1c, and mortality in individuals with CFRD.

Journal article

Hill AT, Pasteur M, Cornford C, Welham S, Bilton Det al., 2011, Primary care summary of the British Thoracic Society Guideline on the management of non-cystic fibrosis bronchiectasis, PRIMARY CARE RESPIRATORY JOURNAL, Vol: 20, Pages: 135-140, ISSN: 1471-4418

Journal article

Bilton D, Canny G, Conway S, Dumcius S, Hjelte L, Proesmans M, Tuemmler B, Vavrova V, De Boeck Ket al., 2011, Pulmonary exacerbation: Towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials, JOURNAL OF CYSTIC FIBROSIS, Vol: 10, Pages: S79-S81, ISSN: 1569-1993

Journal article

Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevinek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec Cet al., 2011, Recommendations for the classification of diseases as CFTR-related disorders, JOURNAL OF CYSTIC FIBROSIS, Vol: 10, Pages: S86-S102, ISSN: 1569-1993

Journal article

Ruparelia P, Szczepura KR, Summers C, Solanki CK, Balan K, Newbold P, Bilton D, Peters AM, Chilvers ERet al., 2011, Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 38, Pages: 911-919, ISSN: 1619-7070

Journal article

George PM, Banya W, Pareek N, Bilton D, Cullinan P, Hodson ME, Simmonds NJet al., 2011, Improved Survival at Low Lung Function in Cystic Fibrosis; a cohort study from 1990 to 2007, BMJ 2011; 342:d1008

Journal article

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