Imperial College London
Alternate

ProfessorDianaBilton

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)7801 067 057diana.bilton

 
 
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Location

 

Fulham RoadRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

318 results found

Bilton, 2011, Bronchiectasis, Bronchiectasis, Editors: Floto, Haworth, Publisher: EuropeanRespiratorySociety, ISBN: 9781849840125

This book provides a definitive guide to the management of patients with bronchiectasis.

Book chapter

Bilton D, Jones AL, 2011, Bronchiectasis: epidemiology and causes, BRONCHIECTASIS, Editors: Floto, Haworth, Publisher: EUROPEAN RESPIRATORY SOCIETY, Pages: 1-10

Book chapter

Morgan GE, Parrott H, Bilton D, Agent Pet al., 2011, POSITIVE PRESSURE - A POSITIVE IMPACT ON AIRWAY CLEARANCE AT HOME, Publisher: WILEY-BLACKWELL, Pages: 351-352, ISSN: 8755-6863

Conference paper

Kernan NG, Cullinan P, Alton EWFW, Bilton D, Griesenbach Uet al., 2010, ORAL CONTRACEPTIVE USE DOES NOT AFFECT CF DISEASE SEVERITY, Publisher: B M J PUBLISHING GROUP, Pages: A121-A121, ISSN: 0040-6376

Conference paper

Salako M, MacNeill SJ, Gunn E, Baker M, Bilton D, Cullinan Pet al., 2010, DISPARITIES IN CARE OF ADULT CF PATIENTS IN THE UK, Publisher: B M J PUBLISHING GROUP, Pages: A172-A173, ISSN: 0040-6376

Conference paper

Pasteur MC, Bilton D, Hill AT, 2010, British Thoracic Society guideline for non-CF bronchiectasis, THORAX, Vol: 65, Pages: 577-577, ISSN: 0040-6376

Journal article

Pasteur MC, Bilton D, Hill AT, 2010, British Thoracic Society guideline for non-CF bronchiectasis, THORAX, Vol: 65, Pages: I1-I58, ISSN: 0040-6376

Journal article

McKeon DJ, Cadwallader KA, Idris S, Cowburn AS, Pasteur MC, Barker H, Haworth CS, Bilton D, Chilvers ER, Condliffe AMet al., 2010, Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation, EUROPEAN RESPIRATORY JOURNAL, Vol: 35, Pages: 1264-1272, ISSN: 0903-1936

Journal article

Adler AI, Bilton D, Haworth C, Shine Bet al., 2010, Hyperglycemia and Death in Cystic Fibrosis Related Diabetes, 70th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A505-A505, ISSN: 0012-1797

Conference paper

Shead EF, Haworth CS, Barker H, Bilton D, Compston JEet al., 2010, Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis, JOURNAL OF CYSTIC FIBROSIS, Vol: 9, Pages: 93-98, ISSN: 1569-1993

Journal article

Chamnan P, Shine BSF, Haworth CS, Bilton D, Adler AIet al., 2010, Diabetes as a Determinant of Mortality in Cystic Fibrosis, DIABETES CARE, Vol: 33, Pages: 311-316, ISSN: 0149-5992

Journal article

Srivastava SA, Nguyen TTB, Burgess JC, Bilton D, Hodson ME, Gyi KM, Baker EHet al., 2010, Breath glucose as a marker of pulmonary inflammation in adult patients with cystic fibrosis, North American Cystic Fibrosis Conference, Pages: 375-375

Conference paper

Srivastava SA, Burgess JC, Bilton D, Hodson ME, Gyi KM, Baker EHet al., 2010, Is HbA1C a useful marker for pulmonary exacerbations in patients with CF but no known diabetes?, North American Cystic Fibrosis Conference, Pages: 375-375

Conference paper

Kernan NG, Cullinan P, Alton EW, Bilton D, Griesenbach Uet al., 2010, ORAL CONTRACEPTIVE USE DOES NOT AFFECT CF DISEASE SEVERITY, PEDIATRIC PULMONOLOGY, Pages: 250-250, ISSN: 8755-6863

Journal article

Bilton D, Robinson P, Cooper P, Kolbe J, Gallagher CG, Fox H, Charlton Bet al., 2010, LONG TERM ADMINISTRATION OF INHALED DRY POWDER MANNITOL IN CF: RESULTS FROM THE OPEN LABEL PHASE III DPM-CF-301 STUDY, Publisher: WILEY, Pages: 321-321, ISSN: 8755-6863

Conference paper

Hurt K, Perrin FM, Gyi K, Bilton Det al., 2010, RETROSPECTIVE REVIEW AND CASE CONTROL STUDY OF CYSTIC FIBROSIS PATIENTS WITH <i>MYCOBACTERIUM ABSCESSUS</i> INFECTION, PEDIATRIC PULMONOLOGY, Pages: 324-325, ISSN: 8755-6863

Journal article

Jones A, Bilton D, Evans TW, Finney SJet al., 2010, PREDICTORS OF OUTCOME IN PATIENTS WITH CYSTIC FIBROSIS REQUIRING ENDOTRACHEAL INTUBATION, Publisher: WILEY, Pages: 364-365, ISSN: 8755-6863

Conference paper

Goldman MD, Nazeran H, Ramos C, Toon E, Oates K, Bilton D, Meraz E, Hafezi N, Diong Bet al., 2010, Electrical Circuit Models of the Human Respiratory System Reflect Small Airway Impairment Measured by Impulse Oscillation (IOS), 32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10), Publisher: IEEE, Pages: 2467-2472, ISSN: 1557-170X

Conference paper

Duff R, Simmonds N, Pantelidis P, Wilson R, Davies J, Alton E, Cookson W, Moffat M, Bilton Det al., 2009, MOLECULAR DETECTION OF COMPLEX MICROBIAL COMMUNITIES IN SPUTA OF PATIENTS WITH CYSTIC FIBROSIS AND NON-CF BRONCHIECTASIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A63-A63, ISSN: 0040-6376

Conference paper

Loebinger MR, Bilton D, Wilson R, 2009, Upper airway . 2: Bronchiectasis, cystic fibrosis and sinusitis, THORAX, Vol: 64, Pages: 1096-1101, ISSN: 0040-6376

Journal article

Srivastava SA, Burgess JC, Gyi KM, Hodson ME, Bilton D, Baker EHet al., 2009, RELATIONSHIP BETWEEN HBA1C AND LUNG DISEASE IN PATIENTS WITH CYSTIC FIBROSIS NOT KNOWN TO HAVE DIABETES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A112-A112, ISSN: 0040-6376

Conference paper

Perrin FMR, Padley S, Gyi KM, Bilton D, Hodson MEet al., 2009, RECURRENT SEVERE HAEMOPTYSIS IN CYSTIC FIBROSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A112-A112, ISSN: 0040-6376

Conference paper

Dhasmana DJ, Dack K, Gyi K, Hodson ME, Bilton Det al., 2009, DEVELOPMENT OF AN ADULT "CYSTIC FIBROSIS SWINE FLU TRIAGE SERVICE'' IN A LONDON TERTIARY REFERRAL CENTRE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A174-A174, ISSN: 0040-6376

Conference paper

Foweraker JE, Laughton CR, Brown DF, Bilton Det al., 2009, Comparison of Methods To Test Antibiotic Combinations against Heterogeneous Populations of Multiresistant <i>Pseudomonas aeruginosa</i> from Patients with Acute Infective Exacerbations in Cystic Fibrosis, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 53, Pages: 4809-4815, ISSN: 0066-4804

Journal article

Tsang KW, Bilton D, 2009, Clinical challenges in managing bronchiectasis, RESPIROLOGY, Vol: 14, Pages: 637-650, ISSN: 1323-7799

Journal article

Davies JC, Bilton D, 2009, Bugs, biofilms, and resistance in cystic fibrosis., Respir Care, Vol: 54, Pages: 628-640, ISSN: 0020-1324

Bacteria infect the respiratory tract early in the course of cystic fibrosis disease, often fail to be eradicated, and together with an aggressive host inflammatory response, are thought to be key players in the irreversible airway damage from which most patients ultimately die. Although incompletely understood, certain aspects of the cystic fibrosis airway itself appear to favor the development of chronic modes of survival, in particular biofilm formation; this and the development of antibiotic resistance following exposure to multiple antibiotic courses lead to chronic, persistent infection. In addition to the common cystic fibrosis pathogens, such as Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa, several newer species are becoming more common. Furthermore, new molecular techniques have led to the identification of multiple different organisms within respiratory secretions, many of which are not cultured with conventional tools. Future work should aim to develop clinically applicable methods to identify these and to determine which have the potential to impact pulmonary health. We outline the basic tenets of infection control and treatment.

Journal article

Davies JC, Bilton D, 2009, Bugs, Biofilms, and Resistance in Cystic Fibrosis, 43rd Respiratory Care Journal Conference on Respiratory Care and Cystic Fibrosis, Publisher: DAEDALUS ENTERPRISES INC, Pages: 628-638, ISSN: 0020-1324

Conference paper

Gillham MI, Sundaram S, Laughton CR, Haworth CS, Bilton D, Foweraker JEet al., 2009, Variable antibiotic susceptibility in populations of <i>Pseudomonas aeruginosa</i> infecting patients with bronchiectasis, Winter Meeting of the British-Thoracic-Society, Publisher: OXFORD UNIV PRESS, Pages: 728-732, ISSN: 0305-7453

Conference paper

Gillham MI, Sundaram S, Laughton CR, Haworth CS, Bilton D, Foweraker JEet al., 2009, Variable antibiotic susceptibility in populations of Pseudomonas aeruginosa infecting patients with bronchiectasis., J Antimicrob Chemother, Vol: 63, Pages: 728-732

OBJECTIVES: To investigate variability in colony morphology and antibiotic susceptibility in populations of Pseudomonas aeruginosa from sputa of patients with bronchiectasis without cystic fibrosis (CF) compared with P. aeruginosa isolated from patients with CF, and from other infections as controls. METHODS: P. aeruginosa was cultured from 31 patients with non-CF bronchiectasis, 24 with CF, 7 ventilated patients and 9 skin swabs. Four colonies of each morphotype of P. aeruginosa were tested for susceptibility to 12 antibiotics by disc diffusion. The variability in susceptibility between the isolates in each patient's population of P. aeruginosa was investigated. RESULTS: The classic morphotype of P. aeruginosa was cultured from control samples with an average variation in zone size of 2 mm (range 0-4 mm) for the four colonies tested. Non-CF bronchiectasis sputa contained 1-3 colonial morphotypes of P. aeruginosa; the average difference between the largest and smallest zone sizes found in all examples of the morphotypes present in each sample varied from 3 mm (1-9 mm) for colistin to 8 mm (0-24 mm) for piperacillin/tazobactam. CF sputa contained 2-6 morphotypes of P. aeruginosa with a wider variation of susceptibility. There was variation between bacteria of the same morphotype from non-CF bronchiectasis and CF sputa. CONCLUSIONS: Phenotypic variation in colonial form and antibiotic susceptibility is not unique to chronic infection in CF but is also found in non-CF bronchiectasis. This questions the use of current susceptibility testing methods for the complex populations of bacteria found in chronic lung infection.

Journal article

Sundaram S, Herrod T, Oates K, Haworth C, Foweraker J, Bilton Det al., 2009, Exacerbations in Non CF Bronchiectasis - Defining Clinical Endpoints To Measure Treatment Efficacy in Future Trials., Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

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