Publications
318 results found
Ruparelia P, Szczepura K, Bilton D, et al., 2006, Granulocyte trafficking in chronic obstructive pulmonary disease, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II108-II109, ISSN: 0040-6376
Brown H, Goldsmith K, Cobain J, et al., 2006, An audit of the new eFLOW®rapid system in the papworth adult CF unit, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II120-II120, ISSN: 0040-6376
Shead E, Haworth C, Barker H, et al., 2006, Alterations in bone metabolism occur at times of infective exacerbation in adults with cystic fibrosis, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II35-II35, ISSN: 0040-6376
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- Citations: 1
Bilton D, Henig N, Morrissey B, et al., 2006, Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of <i>Pseudomonas aeruginosa</i> infection in adult bronchiectasis, CHEST, Vol: 130, Pages: 1503-1510, ISSN: 0012-3692
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- Citations: 112
Nash KL, Collier JD, Hawarth C, et al., 2006, Cystic fibrosis and liver transplantation: A single centre experience, 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 412A-412A, ISSN: 0270-9139
Shead EF, Haworth CS, Gunn E, et al., 2006, Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 174, Pages: 306-311, ISSN: 1073-449X
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- Citations: 43
Martin SL, Downey D, Bilton D, et al., 2006, Safety and efficacy of recombinant alpha<sub>1</sub>-antitrypsin therapy in cystic fibrosis, PEDIATRIC PULMONOLOGY, Vol: 41, Pages: 177-183, ISSN: 8755-6863
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- Citations: 85
Al Ansari NA, Foweraker J, Mackeown D, et al., 2006, Evaluation of once daily tobramycin versus the traditional three time daily for the treatment of acute pulmonary exacerbations in adult cystic fibrosis patients, Qatar Medical Journal, Vol: 15, Pages: 34-38, ISSN: 0253-8253
Once daily tobramycin is convenient to use and achieves higher tissue levels that should kill Pseudomonas aeruginosa more rapidly. Small trials of OD compared with TDS aminoglycosides in CF patients have shown no difference in efficacy or toxicity. No one has looked in detail at the impact on sputum microbiology. In a prospective, randomized study at Popworth Hospital, UK, we compared OD with TDS tobramycin, each plus a second anti-pseudomonal, for the treatment of acute infective exacerbation in 15 adult cystic fibrosis patients colonized with Pseudomonas aeruginosa. Using the patients as their own control, the same individuals received the alternate treatment regime for the next exacerbation. We aimed to compare the clinical and bacteriological, efficacy, toxicity, and the effects on susceptibility of the organism among patients in both treatment groups. Isolates were identified, and the Minimum Inhibitory Concentration (MIC) of the antibiotic in each patient was performed. Patients were assessed for clinical improvement, toxicity and the total viable count in their sputum on days 0, 7 and 14. In both treatment groups there was a significant clinical improvement, and toxicity did not occur in either group. There was no difference in clinical outcome, adverse events, or time to the next exacerbation. No difference was seen in the selection of antibiotic resistance. OD tobramycin appeared more effective in reducing the number of bacteria in the group overall at day 7 and in two individuals, at day 14.
McKeon DJ, Cadwallader KA, Condliffe AM, et al., 2005, The function and fate of neutrophils in cystic fibrosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II93-II94, ISSN: 0040-6376
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- Citations: 1
Toon E, Bilton D, Goldman MD, et al., 2005, Utility of impulse oscillometry in predicting gas trapping in cystic fibrosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II91-II91, ISSN: 0040-6376
Shead E, Haworth C, Gunn E, et al., 2005, Osteoclast formation potential from haematopoietic precursors is altered during infective exacerbation in adult cystic fibrosis patients, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II27-II27, ISSN: 0040-6376
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- Citations: 1
Chapman E, Landy A, Lyon A, et al., 2005, End of life care for adult cystic fibrosis patients: facilitating a good enough death., J Cyst Fibros, Vol: 4, Pages: 249-257, ISSN: 1569-1993
BACKGROUND: There is little empirical research on end of life care for CF patients from qualitative, psychosocial perspectives or which examines how staff members manage specific issues raised by cystic fibrosis deaths. This study examined how a number of recent deaths have been handled in an adult CF centre in the UK. METHODS: Multi-perspective psychosocial interview study with patients, staff, and relatives of decedents. Team meetings were observed. Interviews were analysed using a qualitative methodology (Interpretative Phenomenological Analysis). Observational analyses were used to assess the team's interactions when dealing with end of life issues with patients. RESULTS: Analysis of interviews uncovered themes which addressed the team's questions on care and support of patients with end-stage CF as follows: talking about death and dying; the multidisciplinary team; difficulties for the staff and saying goodbye; active versus palliative care. As a result of psychological input with the multidisciplinary team, staff felt supported and developed the ability to talk openly and in good time to patients regarding their deaths and their wishes for treatment at the end of life. CONCLUSION: The team felt that they had reached a foundation upon which to propose a model of care at the end of life for adult cystic fibrosis patients.
Shead E, Haworth C, Gunn E, et al., 2005, Osteoclast formation potential is increased at times of pulmonary infection in adults with cystic fibrosis, Annual Meeting of the Bone-and-Tooth-Society, Publisher: AMER SOC BONE & MINERAL RES, Pages: 1297-1297, ISSN: 0884-0431
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- Citations: 1
Foweraker JE, Laughton CR, Brown DFJ, et al., 2005, Phenotypic variability of <i>Pseudomonas</i> <i>aeruginosa</i> in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 55, Pages: 921-927, ISSN: 0305-7453
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- Citations: 135
Kerem E, Conway S, Elborn S, et al., 2005, Standards of care for patients with cystic fibrosis: a European consensus., J Cyst Fibros, Vol: 4, Pages: 7-26, ISSN: 1569-1993
McKeon DJ, Haworth C, Bradley JR, et al., 2005, Cystic Fibrosis pulmonary disease is not a contra-indication to live-related renal transplantation, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 20, Pages: 664-664, ISSN: 0931-0509
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- Citations: 1
Whitehouse JL, Exley AR, Foweraker J, et al., 2005, Chronic <i>Burkholderia multivorans</i> bronchial infection in a non-cystic fibrosis individual with mannose binding lectin deficiency, THORAX, Vol: 60, Pages: 168-170, ISSN: 0040-6376
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- Citations: 5
Adler AI, Gunn E, Haworth CS, et al., 2005, Risk factors for cystic fibrosis-related diabetes, 65th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A256-A257, ISSN: 0012-1797
Chapman E, Bilton D, 2004, Patients' knowledge of cystic fibrosis: genetic determinism and implications for treatment., J Genet Couns, Vol: 13, Pages: 369-385, ISSN: 1059-7700
This paper uses the self-regulation model of illness perceptions (Leventhal et al. , 1984) to consider the implications of different ways of thinking about the causes of illness. The relationship between anxiety/depression and knowledge or denial of illness is also considered. These issues are explored using adherence to treatment in cystic fibrosis (CF) as an example. Twenty-six CF patients took part in semistructured interviews and completed a standardized anxiety and depression scale (HAD, Zigmond and Snaith, 1983). Interview data were analyzed using Interpretative Phenomenological Analysis (Chapman and Smith, 2002). HAD data were analyzed using SPSS. The respondents displayed widely differing levels of knowledge of their condition. Some deterministic comments were also reported. Findings are discussed in relation to the information that physicians might provide to patients and families in the light of increasing knowledge about genetics in society and the genotyping of individuals with genetic conditions specifically. Any important gaps in patient knowledge could usefully be discussed at transition from pediatric to adult care and issues relating to control and genetic determinism discussed with the patients individually.
McKeon D, Day A, Parmar J, et al., 2004, Hepatocellular carcinoma in association with cirrhosis in a patient with cystic fibrosis., J Cyst Fibros, Vol: 3, Pages: 193-195, ISSN: 1569-1993
BACKGROUND: Cystic fibrosis liver disease (CFLD) occurs in 37% of patients with CF. To date and to the best of our knowledge, there has not been a documented case of hepatocellular carcinoma in association with cirrhosis and CF. CASE REPORT: A 32-year-old lady with cystic fibrosis (CF) presented for her annual review. She had been diagnosed with CFLD since early adolescence. A routine ultrasound of her liver revealed lesions consistent with hepatocellular carcinoma. This was confirmed on histology. She had no risk factors for hepatitis, and thorough investigation revealed no other cause for her chronic liver disease. She was also found to be pregnant at the time of diagnosis. Her tumour was considered too large for resection and liver transplantation and she was referred to a national centre for laser ablative therapy. CONCLUSION: It is our concern that with the increased life expectancy of patients with CF and the chronic nature of CFLD that this may be an increasingly recognised complication amongst the CF adult population. Therefore, we have changed our practice to more intense surveillance of patients with established CFLD to incorporate biannual ultrasound imaging of the hepatic system and yearly serum concentration measurements of alpha-fetoprotein.
Pearce DM, Foweraker JE, Laughton CR, et al., 2003, Changes to colonising genotypes of pseudomonas aeruginosa with treatment of acute exacerbation of cystic fibrosis, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 63-63, ISSN: 0040-6376
French J, Bilton D, Campbell F, 2003, Nurse specialist care for bronchiectasis., Cochrane Database Syst Rev
BACKGROUND: Nurses have expanded and developed their roles to meet the needs of patients. This review evaluates the safety, effectiveness and health outcomes of nurses practising in autonomous roles, using advanced practice skills, within the context of a dedicated bronchiectasis clinic. OBJECTIVES: To determine the effectiveness of nurse-led care in the management of bronchiectasis. SEARCH STRATEGY: The Cochrane Airways Group specialised register was searched on 12/06/02. SELECTION CRITERIA: Randomised controlled trials were eligible for inclusion in the review. DATA COLLECTION AND ANALYSIS: Two reviewers extracted and entered data from included studies. MAIN RESULTS: One study was included in the review. No statistically significant changes were observed in infective exacerbations, lung function, exercise capacity, quality of life and hospital admissions. More healthcare resources were utilised by nurse-treated participants during the first arm of the study. REVIEWER'S CONCLUSIONS: This review has found one trial that does not demonstrate significant differences in clinical outcomes between nurse led care and doctor led care within the setting of a specialist clinic is, but there may be increased cost implications. Further research is required to review whether nurse led care provides the same outcomes in the community or secondary care setting.
Lyon A, Bilton D, 2002, Fertility issues in cystic fibrosis., Paediatr Respir Rev, Vol: 3, Pages: 236-240, ISSN: 1526-0542
With increasing survival in cystic fibrosis (CF) there is an increasing need to deal with the desires of CF patients to become parents. In the context of 98% male infertility in CF, new techniques offer the prospect of successful parenthood. For females, successful pregnancy is possible but careful planning is required. The practical and ethical aspects of reproductive health in CF are discussed.
Parmar JS, Howell T, Kelly J, et al., 2002, Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis, THORAX, Vol: 57, Pages: 749-750, ISSN: 0040-6376
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- Citations: 34
Sharples LD, Edmunds J, Bilton D, et al., 2002, A randomised controlled crossover trial of nurse practitioner versus doctor led outpatient care in a bronchiectasis clinic, THORAX, Vol: 57, Pages: 661-666, ISSN: 0040-6376
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- Citations: 45
Parmar JS, Mahadeva R, Reed BJ, et al., 2002, Polymers of α<sub>1</sub>-antitrypsin are chemotactic for human neutrophils -: A new paradigm for the pathogenesis of emphysema, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 26, Pages: 723-730, ISSN: 1044-1549
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- Citations: 115
Stoica SC, Lockowandt U, Coulden R, et al., 2002, Double aortic arch masquerading as asthma for thirty years, RESPIRATION, Vol: 69, Pages: 92-95, ISSN: 0025-7931
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- Citations: 16
Caine N, Sharples LD, Hollingworth W, et al., 2002, A randomised controlled crossover trial of nurse practitioner versus doctor-led outpatient care in a bronchiectasis clinic., Health Technol Assess, Vol: 6, Pages: 1-71, ISSN: 1366-5278
Al-Ansari N, McKeon D, Parmar J, et al., 2001, Efficacy of once daily tobramycin for acute pulmonary exacerbations of cystic fibrosis (CF) - A microbiological perspective, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 84-85, ISSN: 0040-6376
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- Citations: 6
Mahadeva R, Sharples L, Ross-Russell RI, et al., 2001, Association of α<sub>1</sub>-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis, THORAX, Vol: 56, Pages: 53-58, ISSN: 0040-6376
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- Citations: 29
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