Imperial College London
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DrDipenderGill

Faculty of Medicine, School of Public Health

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)7904 843 810dipender.gill

 
 
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Location

 

School of a Public HealthMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Larsson:2021:10.3390/nu13051504,
author = {Larsson, SC and Gill, D},
doi = {10.3390/nu13051504},
journal = {Nutrients},
pages = {1--5},
title = {Genetic evidence supporting fibroblast growth factor 21 signalling as a pharmacological target for cardiometabolic outcomes and Alzheimer's disease},
url = {http://dx.doi.org/10.3390/nu13051504},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer’s disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the FGF21 gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The FGF21 G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer’s disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.
AU  - Larsson,SC
AU  - Gill,D
DO  - 10.3390/nu13051504
EP  - 5
PY  - 2021///
SN  - 2072-6643
SP  - 1
TI  - Genetic evidence supporting fibroblast growth factor 21 signalling as a pharmacological target for cardiometabolic outcomes and Alzheimer's disease
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu13051504
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000662433700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2072-6643/13/5/1504
UR  - http://hdl.handle.net/10044/1/94510
VL  - 13
ER  -
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