Imperial College London
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DrDipenderGill

Faculty of Medicine, School of Public Health

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)7904 843 810dipender.gill

 
 
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Location

 

School of a Public HealthMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carter:2022:ije/dyac002,
author = {Carter, AR and Harrison, S and Gill, D and Davey, Smith G and Taylor, AE and Howe, LD and Davies, NM},
doi = {ije/dyac002},
journal = {Int J Epidemiol},
pages = {885--897},
title = {Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.},
url = {http://dx.doi.org/10.1093/ije/dyac002},
volume = {51},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease. METHODS: In up to 320120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases. RESULTS: On the additive scale, higher educational attainment reduced genetic susceptibility to higher body mass index, smoking, atrial fibrillation and type 2 diabetes, but increased genetic susceptibility to higher LDL-C and higher systolic blood pressure. On the multiplicative scale, there was evidence that higher educational attainment increased genetic susceptibility to atrial fibrillation and coronary heart disease, but little evidence of effect modification was found for all other traits considered. CONCLUSIONS: Educational attainment modifies the genetic susceptibility to some cardiovascular risk factors and diseases. The direction of this effect was mixed across traits considered and differences in associations between the effect of the polygenic score across strata of educational attainment was uniformly small. Therefore, any effect modification by education of genetic susceptibility to cardiovascular risk factors or diseases is unlikely to substantially explain the development of inequalities in cardiovascular risk.
AU  - Carter,AR
AU  - Harrison,S
AU  - Gill,D
AU  - Davey,Smith G
AU  - Taylor,AE
AU  - Howe,LD
AU  - Davies,NM
DO  - ije/dyac002
EP  - 897
PY  - 2022///
SP  - 885
TI  - Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.
T2  - Int J Epidemiol
UR  - http://dx.doi.org/10.1093/ije/dyac002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35134953
VL  - 51
ER  -
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