Imperial College London
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DrDipenderGill

Faculty of Medicine, School of Public Health

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)7904 843 810dipender.gill

 
 
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Location

 

School of a Public HealthMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ryan:2022:10.1212/NXG.0000000000200014,
author = {Ryan, DK and Karhunen, V and Su, B and Traylor, M and Richardson, TG and Burgess, S and Tzoulaki, I and Gill, D},
doi = {10.1212/NXG.0000000000200014},
journal = {Neurology Genetics},
title = {Genetic evidence for protective effects of angiotensin converting enzyme against Alzheimer's disease but not other neurodegenerative diseases in European populations},
url = {http://dx.doi.org/10.1212/NXG.0000000000200014},
volume = {8},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and Objectives: Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed class of medication used to treat heart failure, hypertension, and chronic kidney disease. However, previous observational studies have shown conflicting directions of associations between ACE inhibitors and risk of Alzheimer disease. Genetic evidence has supported a protective effect of cerebral ACE against Alzheimer disease (AD). However, it is unclear whether this effect is mediated through blood pressure and extends to other neurodegenerative diseases.Methods: We performed genetic colocalization investigating an effect of cortical ACE expression on AD risk in people of European ancestry. We further investigated whether any effect of ACE expression on AD risk is mediated through changes in blood pressure and whether effects extend to Parkinson disease, small-vessel disease, or cognitive function in a Mendelian randomization paradigm.Results: There was genetic evidence supporting a protective effect of cortical ACE expression on AD risk in people of European ancestry. Although higher cortical ACE expression was associated with higher blood pressure, there was no strong evidence to support that its association with AD was mediated through blood pressure nor that ACE expression affected risk of other neurodegenerative traits.Discussion: Genetic evidence supports protective effects of cerebral ACE expression on AD, but not other neurodegenerative outcomes in people of European ancestry. Further work is required to investigate whether therapeutic inhibition of ACE increases risk of Alzheimer disease.
AU  - Ryan,DK
AU  - Karhunen,V
AU  - Su,B
AU  - Traylor,M
AU  - Richardson,TG
AU  - Burgess,S
AU  - Tzoulaki,I
AU  - Gill,D
DO  - 10.1212/NXG.0000000000200014
PY  - 2022///
SN  - 2376-7839
TI  - Genetic evidence for protective effects of angiotensin converting enzyme against Alzheimer's disease but not other neurodegenerative diseases in European populations
T2  - Neurology Genetics
UR  - http://dx.doi.org/10.1212/NXG.0000000000200014
UR  - http://hdl.handle.net/10044/1/97692
VL  - 8
ER  -
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