Imperial College London
Alternate

DrDuncanRogers

Faculty of Medicine, National Heart & Lung Institute

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Contact

 

+44 (0)20 7352 8121 ext 3051duncan.rogers

 
 
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Location

 

G232Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

137 results found

Rogers DF, 1996, Scorpion venoms: Taking the sting out of lung disease, THORAX, Vol: 51, Pages: 546-548, ISSN: 0040-6376

Journal article

Rogers DF, Laurent GJ, 1996, Introduction, THORAX, Vol: 51, Pages: 217-217, ISSN: 0040-6376

Journal article

Lei YH, Barnes PJ, Rogers DF, 1996, Involvement of hydroxyl radicals in neurogenic airway plasma exudation and bronchoconstriction in guinea-pigs in vivo, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 117, Pages: 449-454, ISSN: 0007-1188

Journal article

Tetley TD, Rogers DF, 1996, Development of new treatments for lung disease, Pages: 5-23, ISSN: 0954-6111

Conference paper

LEI YH, BARNES PJ, ROGERS DF, 1995, MECHANISMS AND MODULATION OF AIRWAY PLASMA EXUDATION AFTER DIRECT INHALATION OF CIGARETTE-SMOKE, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 151, Pages: 1752-1762, ISSN: 1073-449X

Journal article

HAYES JP, KUO HP, ROHDE JAL, TAYLOR AJN, BARNES PJ, CHUNG KF, ROGERS DFet al., 1995, NEUROGENIC GOBLET CELL SECRETION AND BRONCHOCONSTRICTION IN GUINEA-PIGS SENSITIZED TO TRIMELLITIC ANHYDRIDE, EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, Vol: 292, Pages: 127-134, ISSN: 0926-6917

Journal article

RAMNARINE SI, HIRAYAMA Y, BARNES PJ, ROGERS DFet al., 1994, SENSORY-EFFERENT NEURAL CONTROL OF MUCUS SECRETION - CHARACTERIZATION USING TACHYKININ RECEPTOR ANTAGONISTS IN FERRET TRACHEA IN-VITRO, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 113, Pages: 1183-1190, ISSN: 0007-1188

Journal article

LEI YH, BARNES PJ, ROGERS DF, 1993, INHIBITION OF NEUROGENIC PLASMA EXUDATION AND BRONCHOCONSTRICTION BY A K+ CHANNEL ACTIVATOR, BRL-38227, IN GUINEA-PIG AIRWAYS IN-VIVO, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 239, Pages: 257-259, ISSN: 0014-2999

Journal article

HIRAYAMA Y, LEI YH, BARNES PJ, ROGERS DFet al., 1993, EFFECTS OF 2 NOVEL TACHYKININ ANTAGONISTS, FK224 AND FK888, ON NEUROGENIC AIRWAY PLASMA EXUDATION, BRONCHOCONSTRICTION AND SYSTEMIC HYPOTENSION IN GUINEA-PIGS INVIVO, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 108, Pages: 844-851, ISSN: 0007-1188

Journal article

LEI YH, BARNES PJ, ROGERS DF, 1993, REGULATION OF NANC NEURAL BRONCHOCONSTRICTION INVIVO IN THE GUINEA-PIG - INVOLVEMENT OF NITRIC-OXIDE, VASOACTIVE-INTESTINAL-PEPTIDE AND SOLUBLE GUANYLYL CYCLASE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 108, Pages: 228-235, ISSN: 0007-1188

Journal article

ALTON E, ROGERS DF, LOGANSINCLAIR R, YACOUB M, BARNES PJ, GEDDES DMet al., 1992, BIOELECTRIC PROPERTIES OF CYSTIC-FIBROSIS AIRWAYS OBTAINED AT HEART-LUNG TRANSPLANTATION, THORAX, Vol: 47, Pages: 1010-1014, ISSN: 0040-6376

Journal article

HUI KP, LOTVALL J, ROGERS DF, BARNES PJ, CHUNG FKet al., 1992, OVALBUMIN AEROSOL CHALLENGE IN ACTIVELY SENSITIZED GUINEA-PIGS - RELATIONSHIP BETWEEN AIRWAY MICROVASCULAR LEAKAGE AND AIR-FLOW OBSTRUCTION, ALLERGY, Vol: 47, Pages: 527-531, ISSN: 0105-4538

Journal article

KUO HP, ROHDE JAL, BARNES PJ, ROGERS DFet al., 1992, CIGARETTE SMOKE-INDUCED AIRWAY GOBLET CELL SECRETION - DOSE-DEPENDENT DIFFERENTIAL NERVE ACTIVATION, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 263, Pages: L161-L167, ISSN: 0002-9513

Journal article

KUO HP, ROHDE JAL, BARNES PJ, ROGERS DFet al., 1992, K+ CHANNEL ACTIVATOR INHIBITION OF NEUROGENIC GOBLET CELL SECRETION IN GUINEA-PIG TRACHEA, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 215, Pages: 297-299, ISSN: 0014-2999

Journal article

LEI YH, BARNES PJ, ROGERS DF, 1992, INHIBITION OF NEUROGENIC PLASMA EXUDATION IN GUINEA-PIG AIRWAYS BY CP-96,345, A NEW NONPEPTIDE NK(1) RECEPTOR ANTAGONIST, Publisher: STOCKTON PRESS, Pages: 261-262, ISSN: 0007-1188

Conference paper

KUO HP, ROHDE JAL, BARNES PJ, ROGERS DFet al., 1992, DIFFERENTIAL INHIBITORY EFFECTS OF OPIOIDS ON CIGARETTE-SMOKE, CAPSAICIN AND ELECTRICALLY-INDUCED GOBLET CELL SECRETION IN GUINEA-PIG TRACHEA, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 105, Pages: 361-366, ISSN: 0007-1188

Journal article

McDonald-Gibson WJ, Kuo HP, Hall RL, Barnes PJ, Rogers DFet al., 1992, Effect of tachykinins on secretory event rate in cultured guinea-pig tracheal epithelial cells, ISSN: 0954-6111

Conference paper

Kuo HP, Rohde JAL, Barnes PJ, Rogers DFet al., 1992, Cigarette smoke-induced airway goblet cell secretion: Dose-dependent differential nerve activation, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol: 263, ISSN: 0002-9513

We studied the effect of acute inhalation of middle-tar cigarette smoke on airway goblet cell secretion in anesthetized guinea pigs. Secretion induced by a low dose of smoke (10 breaths diluted 1:10 in air) was blocked by either hexamethonium or by filtering out the particulate phase of the smoke. The response was partially inhibited by atropine but was not inhibited by propranolol, phentolamine, or capsaicin pretreatment. Cutting the nerve supply to the airways did not inhibit the response to low-dose smoke. In contrast, goblet cell secretion induced by a high dose of cigarette smoke (20 breaths undiluted) was inhibited by capsaicin pretreatment but not by autonomic receptor blockade nor by filtering out the particulate phase. Secretion induced by the vapor phase of the high dose of cigarette smoke was blocked by capsaicin pretreatment but was not inhibited by hexamethonium. We conclude that in guinea pig airways the particulate phase of low doses of smoke activates cholinergic nerves via stimulation of parasympathetic ganglia, whereas the vapor phase of high doses of smoke activates capsaicin- sensitive sensory nerves.

Journal article

Lei YH, Barnes PJ, Rogers DF, 1992, Inhibition of neurogenic plasma exudation in guinea-pig airways by CP-96,345, a new non-peptide NK-1 receptor antagonist, ISSN: 0954-6111

Conference paper

ROGERS DF, GODFREY RWA, CASTRO K, MAJUMDAR S, JEFFERY PKet al., 1991, EFFECTS OF A NEW COMPOUND (ZY-15850A) ON CIGARETTE SMOKE-INDUCED BRONCHITIS IN THE RAT, AGENTS AND ACTIONS, Vol: 33, Pages: 359-366, ISSN: 0065-4299

Journal article

Rogers DF, Godfrey RW, Castro K, Majumdar S, Jeffery PKet al., 1991, Effects of a new compound (Zy 15850A) on cigarette smoke-induced bronchitis in the rat., Agents Actions, Vol: 33, Pages: 358-366, ISSN: 0065-4299

The effect of 4H-4 phenylthieno-(3,2-C)-(1)-benzopyran-2-carboxylate (Zy 15850A) on mucous cell hyperplasia was examined in vivo using a well established rat model of cigarette smoke-induced bronchitis. Zy 15850A was given by gavage (25 mg/kg body weight) to male rats before and after sub-acute exposure (i.e. daily for 14 days) to an atmosphere of cigarette smoke (CS). CS significantly increased the thickness of the epithelium at three of the four sites studied in the trachea and in both of the intrapulmonary levels examined. CS increased the number of epithelial mucous cells in all intrapulmonary airways and also increased the mass of submucosal gland present in the larynx and upper trachea. Zy 15850A completely inhibited CS-induced increases in epithelial thickness in the upper trachea and the two intrapulmonary airway levels studied, and tended to inhibit CS-induced epithelial mucous cell hyperplasia in all the six intrapulmonary airway levels examined, with statistically significant inhibition in two. Zy 15850A had no inhibitory effect of the CS-induced enlargement of laryngo-tracheal submucosal glands. We conclude that, in the rat, the predominant inhibitory effect of Zy 15850A is on CS-induced epithelial thickening with weaker inhibitory effects on mucous cell hyperplasia and enlargement of submucosal glands. Zy 15850A is less effective than other mucoregulatory drugs or antiinflammatory agents we have tested in the same bronchitic model.

Journal article

BOSCHETTO P, ROGERS DF, FABBRI LM, BARNES PJet al., 1991, CORTICOSTEROID INHIBITION OF AIRWAY MICROVASCULAR LEAKAGE, Publisher: AMER LUNG ASSOC, Pages: 605-609, ISSN: 0003-0805

Conference paper

KUO HP, ROHDE JAL, TOKUYAMA K, BARNES PJ, ROGERS DFet al., 1990, CAPSAICIN AND SENSORY NEUROPEPTIDE STIMULATION OF GOBLET CELL SECRETION IN GUINEA-PIG TRACHEA, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 431, Pages: 629-641, ISSN: 0022-3751

Journal article

ROGERS DF, ALTON E, AURSUDKIJ B, BOSCHETTO P, DEWAR A, BARNES PJet al., 1990, EFFECT OF PLATELET-ACTIVATING-FACTOR ON FORMATION AND COMPOSITION OF AIRWAY FLUID IN THE GUINEA-PIG TRACHEA, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 431, Pages: 643-658, ISSN: 0022-3751

Journal article

BARNES PJ, BOSCHETTO P, ROGERS DF, BELVISI M, ROBERTS N, CHUNG KF, EVANS TWet al., 1990, EFFECTS OF TREATMENT ON AIRWAY MICROVASCULAR LEAKAGE, EUROPEAN RESPIRATORY JOURNAL, Vol: 3, Pages: S663-S671, ISSN: 0903-1936

Journal article

ROGERS DF, DIJK S, BARNES PJ, 1990, BRADYKININ-INDUCED PLASMA EXUDATION IN GUINEA-PIG AIRWAYS - INVOLVEMENT OF PLATELET-ACTIVATING-FACTOR, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 101, Pages: 739-745, ISSN: 0007-1188

Journal article

TOKUYAMA K, KUO HP, ROHDE JAL, BARNES PJ, ROGERS DFet al., 1990, NEURAL CONTROL OF GOBLET CELL SECRETION IN GUINEA-PIG AIRWAYS, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 259, Pages: L108-L115, ISSN: 0002-9513

Journal article

BELVISI MG, BARNES PJ, ROGERS DF, 1990, NEUROGENIC INFLAMMATION IN THE AIRWAYS - CHARACTERIZATION OF ELECTRICAL PARAMETERS FOR VAGUS NERVE-STIMULATION IN THE GUINEA-PIG, JOURNAL OF NEUROSCIENCE METHODS, Vol: 32, Pages: 159-167, ISSN: 0165-0270

Journal article

BARNES PJ, BELVISI MG, ROGERS DF, 1990, MODULATION OF NEUROGENIC INFLAMMATION - NOVEL APPROACHES TO INFLAMMATORY DISEASE, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 11, Pages: 185-189, ISSN: 0165-6147

Journal article

EVANS TW, MCANULTY RJ, ROGERS DF, CHUNG KF, BARNES PJ, LAURENT GJet al., 1990, BLEOMYCIN-INDUCED LUNG INJURY IN THE RAT - EFFECTS OF THE PLATELET-ACTIVATING FACTOR (PAF) RECEPTOR ANTAGONIST BN 52021 AND PLATELET DEPLETION, Publisher: NATL INST ENVIRON HEALTH SCI, Pages: 65-69, ISSN: 0091-6765

Conference paper

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