Publications
137 results found
EVANS TW, ROGERS DF, BELVISI MG, et al., 1990, ENDOTOXIN-INDUCED PLASMA EXUDATION IN GUINEA-PIG AIRWAYS INVIVO AND THE EFFECT OF NEUTROPHIL DEPLETION, EUROPEAN RESPIRATORY JOURNAL, Vol: 3, Pages: 299-303, ISSN: 0903-1936
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- Citations: 5
CHUNG KF, ROGERS DF, BARNES PJ, et al., 1990, THE ROLE OF INCREASED AIRWAY MICROVASCULAR PERMEABILITY AND PLASMA EXUDATION IN ASTHMA, EUROPEAN RESPIRATORY JOURNAL, Vol: 3, Pages: 329-337, ISSN: 0903-1936
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- Citations: 104
Tokuyama K, Kuo HP, Rohde JAL, et al., 1990, Neural control of goblet cell secretion in guinea pig airways, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol: 259, ISSN: 0002-9513
We studied the neural control of goblet cell secretion in the lower airways of anesthetized guinea pigs using a semiquantitative morphometric technique. The magnitude of discharge of intracellular mucus was determined in histological sections of the trachea and main bronchi stained for mucus glycoproteins. Bilateral electrical stimulation of the cervical vagus nerves induced goblet cell secretion. The magnitude of the effect was dependent on the frequency, voltage, and pulse width of the stimulus, and the duration of stimulation. At 10 Hz, 5 V, and 5 ms for 3 min, there was a 62% decrease in the amount of intracellular mucus below that with sham stimulation. The secretion was blocked either by atropine or by pretreatment with capsaicin but was not significantly inhibited by idazoxan, an α-adrenoceptor antagonist. The magnitude of goblet cell discharge in animals pretreated with propranolol was intermediate between that in controls and that with nerve stimultion, although not significant to either. These results demonstrate that goblet cell secretion is under neural control in guinea pig airways and suggest that cholinergic, nonadrenergic-noncholinergic, and possibly adrenergic neural pathways, may contribute to the secretion.
ROGERS DF, ALTON E, DEWAR A, et al., 1990, TRACHEAL POTENTIAL DIFFERENCE IN THE RESERPINE AND ISOPROTERENOL RAT MODELS OF CYSTIC-FIBROSIS, EXPERIMENTAL LUNG RESEARCH, Vol: 16, Pages: 661-670, ISSN: 0190-2148
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- Citations: 3
ROGERS DF, AURSUDKIJ B, BARNES PJ, 1989, EFFECTS OF TACHYKININS ON MUCUS SECRETION IN HUMAN BRONCHI INVITRO, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 174, Pages: 283-286, ISSN: 0014-2999
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- Citations: 119
ROGERS DF, TURNER NC, MARRIOTT C, et al., 1989, ORAL N-ACETYLCYSTEINE OR S-CARBOXYMETHYLCYSTEINE INHIBIT CIGARETTE SMOKE-INDUCED HYPERSECRETION OF MUCUS IN RAT LARYNX AND TRACHEA INSITU, EUROPEAN RESPIRATORY JOURNAL, Vol: 2, Pages: 955-960, ISSN: 0903-1936
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- Citations: 24
ROGERS DF, BOSCHETTO P, BARNES PJ, 1989, PLASMA EXUDATION - CORRELATION BETWEEN EVANS BLUE-DYE AND RADIOLABELED ALBUMIN IN GUINEA-PIG AIRWAYS INVIVO, JOURNAL OF PHARMACOLOGICAL METHODS, Vol: 21, Pages: 309-315, ISSN: 0160-5402
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- Citations: 192
EVANS TW, ROGERS DF, AURSUDKIJ B, et al., 1989, REGIONAL AND TIME-DEPENDENT EFFECTS OF INFLAMMATORY MEDIATORS ON AIRWAY MICROVASCULAR PERMEABILITY IN THE GUINEA-PIG, CLINICAL SCIENCE, Vol: 76, Pages: 479-485, ISSN: 0143-5221
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- Citations: 54
ROGERS DF, BARNES PJ, 1989, OPIOID INHIBITION OF NEURALLY MEDIATED MUCUS SECRETION IN HUMAN BRONCHI, LANCET, Vol: 1, Pages: 930-932, ISSN: 0140-6736
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- Citations: 93
BOSCHETTO P, ROBERTS NM, ROGERS DF, et al., 1989, EFFECT OF ANTIASTHMA DRUGS ON MICROVASCULAR LEAKAGE IN GUINEA-PIG AIRWAYS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 139, Pages: 416-421, ISSN: 0003-0805
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- Citations: 81
BELVISI MG, ROGERS DF, BARNES PJ, 1989, NEUROGENIC PLASMA EXTRAVASATION - INHIBITION BY MORPHINE IN GUINEA-PIG AIRWAYS INVIVO, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 66, Pages: 268-272, ISSN: 8750-7587
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- Citations: 79
ROGERS DF, BELVISI MG, AURSUDKIJ B, et al., 1988, EFFECTS AND INTERACTIONS OF SENSORY NEUROPEPTIDES ON AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIGS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 95, Pages: 1109-1116, ISSN: 0007-1188
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- Citations: 139
EVANS TW, ROGERS DF, AURSUDKIJ B, et al., 1988, INFLAMMATORY MEDIATORS INVOLVED IN ANTIGEN-INDUCED AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIGS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 138, Pages: 395-399, ISSN: 0003-0805
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- Citations: 102
EVANS TW, DENT G, ROGERS DF, et al., 1988, EFFECT OF A PAF ANTAGONIST, WEB-2086, ON AIRWAY MICROVASCULAR LEAKAGE IN THE GUINEA-PIG AND PLATELET-AGGREGATION IN MAN, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 94, Pages: 164-168, ISSN: 0007-1188
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- Citations: 46
AURSUDKIJ B, BARNES PJ, BELVISI MG, et al., 1988, EFFECT OF SUBSTANCE-P, NEUROKININS AND CALCITONIN GENE-RELATED PEPTIDE ON MICROVASCULAR PERMEABILITY IN GUINEA-PIG AIRWAYS, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 398, Pages: P51-P51, ISSN: 0022-3751
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- Citations: 9
EVANS TW, CHUNG KF, ROGERS DF, et al., 1987, EFFECT OF PLATELET-ACTIVATING-FACTOR ON AIRWAY VASCULAR-PERMEABILITY - POSSIBLE MECHANISMS, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 63, Pages: 479-484, ISSN: 8750-7587
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- Citations: 216
EVANS TW, ROGERS DF, ROBERTS NM, et al., 1987, MEDIATORS OF INCREASED VASCULAR-PERMEABILITY DURING ANAPHYLAXIS IN SENSITIZED GUINEA-PIGS, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 221-221, ISSN: 0040-6376
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- Citations: 3
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