DrElinaAkalestou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Lecturer

Contact

Location

ICTEM buildingHammersmith Campus

Summary

Elina Akalestou is a molecular endocrinologist, specialising in bariatric surgery and inter-organ communication. Her research focuses on the effects of bariatric surgery on hypertension and Type 2 Diabetes remission. To do so, she utilizes in vivo models of bariatric surgery, as well as transgenic and in vitro systems to explore the relationship between the gastrointestinal tract and key metabolic organs, including adrenal glands and kidneys.

Elina completed an MSc in Clinical Nutrition in University College London, followed by a PhD in Obesity Drug Development in Imperial College London. She has completed postdoctoral training in Johns Hopkins University, King's College London and Imperial College London. She is currently currently a Lecturer in Cardiovascular Sciences in the University of Leicester and an Honorary Lecturer in the Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism.

Current lab members:

Brett Johnson (PhD student)

Former lab members:

Amira Abdelgawwad (MSc student)

Wenya Wang (MSc student)

Izzy Franco (BSc student)

Shiyi Lian (BSc student)

Niki Brisnovali (MSc student)

Isabella Doria Durazzo (MSc student)

Publications

Journals

Slieker R, Donnellly L, Akalestou E, et al.Slieker R, Donnellly L, Akalestou E, Lopez-Noriega L, Melhem R, Gunes A, Abou Azar F, Efanov A, Georgiadou E, Muniangi-Muhitu H, Shiekh M, Giordano G, Åkerlund, M, Ahlqvist E, Ashfaq A, Banasik K, Brunak S, Barovic M, Bouland G, Burdet F, Canouil M, Dragan I, Elders P, Fernandez C, Festa A, Fitipaldi H, Froguel P, Gudmundsdottir V, Gudnason V, Gerl M, van der Heijden A, Jennings L, Hansen M, Kim M, Leclerc I, Klose C, Kuznetsov D, Mansour Aly D, Mehl F, Marek D, Melander O, Niknejad A, Ottosson F, Pavo I, Duffin K, Syed S, Shaw J, Cabrera O, Pullen T, Simons K, Solimena M, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido Quigley C, Groop L, Thorens B, Franks P, Lim G, Estall J, Ibberson M, Beulens J, ’t Hart L, Pearson E, Rutter G close, 2023, Identification of biomarkers for glycaemic deterioration in type 2 diabetes, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-18

Akalestou E, Lopez-Noriega L, Christakis I, et al.Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras A, Leclerc I, Rutter G close, 2022, Vertical Sleeve Gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice, Frontiers in Endocrinology, Vol:13, ISSN:1664-2392, Pages:1-16

Jones B, Burade V, Akalestou E, et al.Jones B, Burade V, Akalestou E, Manchanda Y, Ramchunder Z, Carrat G, Nguyen-Tu M-S, Marchetti P, Piemonti L, Leclerc I, Thennati R, Vilsboll T, Thorens B, Tomas A, Rutter GA close, 2022, In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist, Diabetes, Obesity and Metabolism: a Journal of Pharmacology and Therapeutics, Vol:24, ISSN:1462-8902, Pages:2090-2101

Akalestou E, Lopez-Noriega L, Tough IR, et al.Akalestou E, Lopez-Noriega L, Tough IR, Hu M, Leclerc I, Cox HM, Rutter GA close, 2022, Vertical sleeve gastrectomy lowers SGLT2/Slc5a2 expression in the mouse kidney, Diabetes, Vol:71, ISSN:0012-1797

Georgiadou E, Muralidharan C, Martinez M, et al.Georgiadou E, Muralidharan C, Martinez M, Chabosseau P, Akalestou E, Tomas A, Yong Su Wern F, Stylianides T, Wretlind A, Legido-Quigley C, Jones B, Lopez Noriega L, Xu Y, Gu G, Alsabeeh N, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Ali Y, Soleimanpour SA, Linnemann AK, Rodriguez TA, Rutter GA close, 2022, Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated beta cell connectivity and insulin secretion, Diabetes, Vol:71, ISSN:0012-1797, Pages:1472-1489

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