Imperial College London
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DrElinaAkalestou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Lecturer
 
 
 
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Contact

 

e.akalestou13

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{McGrath:2019:10.1101/578344,
author = {McGrath, TM and Spreckley, E and Rodriguez, AF and Viscomi, C and Alamshah, A and Akalestou, E and Murphy, KG and Jones, NS},
doi = {10.1101/578344},
title = {The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents},
url = {http://dx.doi.org/10.1101/578344},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of PYY<jats:sub>3-36</jats:sub>, lithium chloride, GLP-1 and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated not mimic satiety. In the<jats:italic>ad libitum</jats:italic>fed state during the light period, meal initiation is governed by complete stomach emptying, whereas in all other conditions there is a graduated response. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake, and how this might be overcome.<jats:italic>In silico</jats:italic>experiments suggest that introducing a minimum intermeal interval or modulating gastric emptying can be as effective as anorectic drug administration.</jats:p>
AU  - McGrath,TM
AU  - Spreckley,E
AU  - Rodriguez,AF
AU  - Viscomi,C
AU  - Alamshah,A
AU  - Akalestou,E
AU  - Murphy,KG
AU  - Jones,NS
DO  - 10.1101/578344
PY  - 2019///
TI  - The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents
UR  - http://dx.doi.org/10.1101/578344
ER  -
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