Dr Elaine Bignell studies pathogenicity of Aspergillus species, in particular, the mechanisms by which these fungi sense and adapt to the host environment. Aspergillus pH- sensing and siderophore-assisted iron uptake are examples of such mechanisms which have recently been characterised during the infection process using murine modelling of Aspergillus infection and fungal molecular genetics.
As of June 2013 Dr Bignell has moved to the Institute of Inflammation and Repair at the University of Manchester. She holds Visiting Academic status with Imperial College London and continues to collaborate with academics at the college.
Huber F, Bignell E, 2014, Distribution, expression and expansion of <i>Aspergillus fumigatus</i> LINE-like retrotransposon populations in clinical and environmental isolates, Fungal Genetics and Biology, Vol:64, ISSN:1087-1845, Pages:36-44
et al., 2013, On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin, Journal of Medicinal Chemistry, Vol:56, ISSN:0022-2623, Pages:8616-8625
et al., 2013, Genetic Bypass of <i>Aspergillus nidulans crzA</i> Function in Calcium Homeostasis, G3-genes Genomes Genetics, Vol:3, ISSN:2160-1836, Pages:1129-1141
et al., 2013, A new and clinically relevant murine model of solid-organ transplant aspergillosis, Disease Models & Mechanisms, Vol:6, ISSN:1754-8403, Pages:643-651
Grice CM, Bertuzzi M, Bignell EM, 2013, Receptor-mediated signaling in <i>Aspergillus fumigatus</i>, Frontiers in Microbiology, Vol:4, ISSN:1664-302X