Publications
47 results found
Huber F, Bignell E, 2014, Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates, FUNGAL GENETICS AND BIOLOGY, Vol: 64, Pages: 36-44, ISSN: 1087-1845
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- Citations: 3
Cherblanc FL, Chapman KL, Reid J, et al., 2013, On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 56, Pages: 8616-8625, ISSN: 0022-2623
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- Citations: 46
Almeida RS, Loss O, Colabardini AC, et al., 2013, Genetic Bypass of Aspergillus nidulans crzA Function in Calcium Homeostasis, G3-GENES GENOMES GENETICS, Vol: 3, Pages: 1129-1141, ISSN: 2160-1836
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- Citations: 8
Herbst S, Shah A, Carby M, et al., 2013, A new and clinically relevant murine model of solid-organ transplant aspergillosis, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 643-651, ISSN: 1754-8403
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- Citations: 29
Grice CM, Bertuzzi M, Bignell EM, 2013, Receptor-mediated signaling in Aspergillus fumigatus, FRONTIERS IN MICROBIOLOGY, Vol: 4, ISSN: 1664-302X
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- Citations: 31
Henk DA, Shahar-Golan R, Devi KR, et al., 2012, Clonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7366
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- Citations: 34
Bhatti MF, Jamal A, Bignell EM, et al., 2012, Incidence of dsRNA Mycoviruses in a Collection of Aspergillus fumigatus Isolates, MYCOPATHOLOGIA, Vol: 174, Pages: 323-326, ISSN: 0301-486X
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- Citations: 22
Bertuzzi M, Grice C, Calcagno-Pizarelli A, et al., 2012, Requirement of PalH-mediated environmental sensing for virulence and tolerance to cell wall-perturbing agents in A. fumigatus: Are PalH and its dimerisation an exploitable target for combination therapy?, MYCOSES, Vol: 55, Pages: 156-156, ISSN: 0933-7407
Yasmin S, Alcazar-Fuoli L, Gruendlinger M, et al., 2012, Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: E497-E504, ISSN: 0027-8424
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- Citations: 81
Bignell E, 2012, The Molecular Basis of pH Sensing, Signaling, and Homeostasis in Fungi, ADVANCES IN APPLIED MICROBIOLOGY, VOL 79, Vol: 79, Pages: 1-18, ISSN: 0065-2164
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- Citations: 17
Bignell EM, 2012, Conservation in Aspergillus fumigatus of pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery, ADVANCES AGAINST ASPERGILLOSIS II, Vol: 1273, Pages: 35-43, ISSN: 0077-8923
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- Citations: 6
Salek-Ardakani S, Cota E, Bignell E, 2012, Host-fungal interactions: key players of antifungal immunity., Expert Rev Anti Infect Ther, Vol: 10(2), Pages: 149-151
Hartmann T, Cairns TC, Olbermann P, et al., 2011, Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence, MOLECULAR MICROBIOLOGY, Vol: 82, Pages: 917-935, ISSN: 0950-382X
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- Citations: 32
Bhatti MF, Jamal A, Petrou MA, et al., 2011, The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus, FUNGAL GENETICS AND BIOLOGY, Vol: 48, Pages: 1071-1075, ISSN: 1087-1845
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- Citations: 53
O'Hanlon KA, Cairns T, Stack D, et al., 2011, Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus, INFECTION AND IMMUNITY, Vol: 79, Pages: 3978-3992, ISSN: 0019-9567
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- Citations: 36
Cherblanc F, Lo Y-P, De Gussem E, et al., 2011, On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 17, Pages: 11868-11875, ISSN: 0947-6539
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- Citations: 27
Bhatti MF, Bignell EM, Coutts RHA, 2011, Complete nucleotide sequences of two dsRNAs associated with a new partitivirus infecting Aspergillus fumigatus, ARCHIVES OF VIROLOGY, Vol: 156, Pages: 1677-1680, ISSN: 0304-8608
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- Citations: 23
Bignell E, 2010, Therapeutic jackpots lie within the reach of multiscale and integrated mycological research., Expert Rev Anti Infect Ther, Vol: 8, Pages: 1333-1335
The 9th International Mycological Congress, hosted by the British Mycological Society and the International Mycological Association, attracted 1600 delegates from around the world. Among the many hundreds of submitted abstracts, plenary lectures and invited talks, the direct relevance of such an eclectic and diverse array of fungal biology to the future sourcing of novel antifungal agents at first glance seems questionable. On the contrary, however, common observations emergent from all of the five scientific themes were the value and timeliness of integrative biology in deciphering the origin and physiological basis of fungal virulence, and the application of basic fungal biology to rationalized fungal anti-infective development, and natural product mining for anti-infective and anti-proliferative product discovery. This article will focus on the extent to which current mycological research can be exploited for novel therapeutic advantage and examines the challenges involved in maximizing the translational potential of such research.
Jamal A, Bignell EM, Coutts RHA, 2010, Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus, VIRUS RESEARCH, Vol: 153, Pages: 64-70, ISSN: 0168-1702
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- Citations: 39
Cairns T, Minuzzi F, Bignell E, 2010, The host-infecting fungal transcriptome, FEMS MICROBIOLOGY LETTERS, Vol: 307, Pages: 1-11, ISSN: 0378-1097
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- Citations: 37
Chamilos G, Bignell EM, Schrettl M, et al., 2010, Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies, MEDICAL MYCOLOGY, Vol: 48, Pages: 506-510, ISSN: 1369-3786
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- Citations: 21
Han K-H, Chun Y-H, Pimentel Figueiredo BDC, et al., 2010, The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (vol 75, pg 1372, 2010), MOLECULAR MICROBIOLOGY, Vol: 76, Pages: 802-802, ISSN: 0950-382X
Bignell E, 2010, Aspergillus: Molecular Biology and Genomics. By Masayuki Machida and Katsuya Gomi (Eds.)., Biotechnol J, Vol: 5, Pages: 336-337, ISSN: 1860-7314
no abstract.
Han K-H, Chun Y-H, Pimentel Figueiredo BDC, et al., 2010, The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans, MOLECULAR MICROBIOLOGY, Vol: 75, Pages: 1372-1388, ISSN: 0950-382X
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- Citations: 20
Armstrong-James DPH, Turnbull SA, Teo I, et al., 2009, Impaired Interferon-gamma Responses, Increased Interleukin-17 Expression, and a Tumor Necrosis Factor-alpha Transcriptional Program in Invasive Aspergillosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 200, Pages: 1341-1351, ISSN: 0022-1899
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- Citations: 28
Bergmann A, Hartmann T, Cairns T, et al., 2009, A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence, INFECTION AND IMMUNITY, Vol: 77, Pages: 4041-4050, ISSN: 0019-9567
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- Citations: 55
McDonagh A, Fedorova ND, Crabtree J, et al., 2008, Sub-telomere directed gene expression during initiation of invasive aspergillosis, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366
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- Citations: 189
de Gouvea PF, Soriani FM, Malavazi I, et al., 2008, Functional characterization of the Aspergillus fumigatus PHO80 homologue, FUNGAL GENETICS AND BIOLOGY, Vol: 45, Pages: 1135-1146, ISSN: 1087-1845
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- Citations: 15
Penalva MA, Tilburn J, Bignell E, et al., 2008, Ambient pH gene regulation in fungi: making connections, TRENDS IN MICROBIOLOGY, Vol: 16, Pages: 291-300, ISSN: 0966-842X
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- Citations: 263
Sasse C, Bignell EM, Hasenberg M, et al., 2008, Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis, FUNGAL GENETICS AND BIOLOGY, Vol: 45, Pages: 693-704, ISSN: 1087-1845
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- Citations: 20
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