Imperial College London

DrElaineBignell

Faculty of EngineeringDepartment of Bioengineering

Visiting Reader
 
 
 
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Contact

 

+44 (0)20 7594 2074e.bignell

 
 
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Location

 

5.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

47 results found

Huber F, Bignell E, 2014, Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates, FUNGAL GENETICS AND BIOLOGY, Vol: 64, Pages: 36-44, ISSN: 1087-1845

Journal article

Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJet al., 2013, On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 56, Pages: 8616-8625, ISSN: 0022-2623

Journal article

Almeida RS, Loss O, Colabardini AC, Brown NA, Bignell E, Savoldi M, Pantano S, Goldman MHS, Arst HN, Goldman GHet al., 2013, Genetic Bypass of Aspergillus nidulans crzA Function in Calcium Homeostasis, G3-GENES GENOMES GENETICS, Vol: 3, Pages: 1129-1141, ISSN: 2160-1836

Journal article

Herbst S, Shah A, Carby M, Chusney G, Kikkeri N, Dorling A, Bignell E, Shaunak S, Armstrong-James Det al., 2013, A new and clinically relevant murine model of solid-organ transplant aspergillosis, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 643-651, ISSN: 1754-8403

Journal article

Grice CM, Bertuzzi M, Bignell EM, 2013, Receptor-mediated signaling in Aspergillus fumigatus, FRONTIERS IN MICROBIOLOGY, Vol: 4, ISSN: 1664-302X

Journal article

Henk DA, Shahar-Golan R, Devi KR, Boyce KJ, Zhan N, Fedorova ND, Nierman WC, Hsueh P-R, Yuen K-Y, Sieu TPM, Nguyen VK, Wertheim H, Baker SG, Day JN, Vanittanakom N, Bignell EM, Andrianopoulos A, Fisher MCet al., 2012, Clonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7366

Journal article

Bhatti MF, Jamal A, Bignell EM, Petrou MA, Coutts RHAet al., 2012, Incidence of dsRNA Mycoviruses in a Collection of Aspergillus fumigatus Isolates, MYCOPATHOLOGIA, Vol: 174, Pages: 323-326, ISSN: 0301-486X

Journal article

Bertuzzi M, Grice C, Calcagno-Pizarelli A, Alcazar-Fuoli L, Kalchschmidt J, Stagljar I, Bignell Eet al., 2012, Requirement of PalH-mediated environmental sensing for virulence and tolerance to cell wall-perturbing agents in A. fumigatus: Are PalH and its dimerisation an exploitable target for combination therapy?, MYCOSES, Vol: 55, Pages: 156-156, ISSN: 0933-7407

Journal article

Yasmin S, Alcazar-Fuoli L, Gruendlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas Het al., 2012, Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: E497-E504, ISSN: 0027-8424

Journal article

Bignell E, 2012, The Molecular Basis of pH Sensing, Signaling, and Homeostasis in Fungi, ADVANCES IN APPLIED MICROBIOLOGY, VOL 79, Vol: 79, Pages: 1-18, ISSN: 0065-2164

Journal article

Bignell EM, 2012, Conservation in Aspergillus fumigatus of pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery, ADVANCES AGAINST ASPERGILLOSIS II, Vol: 1273, Pages: 35-43, ISSN: 0077-8923

Journal article

Salek-Ardakani S, Cota E, Bignell E, 2012, Host-fungal interactions: key players of antifungal immunity., Expert Rev Anti Infect Ther, Vol: 10(2), Pages: 149-151

Journal article

Hartmann T, Cairns TC, Olbermann P, Morschhaeuser J, Bignell EM, Krappmann Set al., 2011, Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence, MOLECULAR MICROBIOLOGY, Vol: 82, Pages: 917-935, ISSN: 0950-382X

Journal article

Bhatti MF, Jamal A, Petrou MA, Cairns TC, Bignell EM, Coutts RHAet al., 2011, The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus, FUNGAL GENETICS AND BIOLOGY, Vol: 48, Pages: 1071-1075, ISSN: 1087-1845

Journal article

O'Hanlon KA, Cairns T, Stack D, Schrettl M, Bignell EM, Kavanagh K, Miggin SM, O'Keeffe G, Larsen TO, Doyle Set al., 2011, Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus, INFECTION AND IMMUNITY, Vol: 79, Pages: 3978-3992, ISSN: 0019-9567

Journal article

Cherblanc F, Lo Y-P, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, Rzepa HS, Fuchter MJet al., 2011, On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 17, Pages: 11868-11875, ISSN: 0947-6539

Journal article

Bhatti MF, Bignell EM, Coutts RHA, 2011, Complete nucleotide sequences of two dsRNAs associated with a new partitivirus infecting Aspergillus fumigatus, ARCHIVES OF VIROLOGY, Vol: 156, Pages: 1677-1680, ISSN: 0304-8608

Journal article

Bignell E, 2010, Therapeutic jackpots lie within the reach of multiscale and integrated mycological research., Expert Rev Anti Infect Ther, Vol: 8, Pages: 1333-1335

The 9th International Mycological Congress, hosted by the British Mycological Society and the International Mycological Association, attracted 1600 delegates from around the world. Among the many hundreds of submitted abstracts, plenary lectures and invited talks, the direct relevance of such an eclectic and diverse array of fungal biology to the future sourcing of novel antifungal agents at first glance seems questionable. On the contrary, however, common observations emergent from all of the five scientific themes were the value and timeliness of integrative biology in deciphering the origin and physiological basis of fungal virulence, and the application of basic fungal biology to rationalized fungal anti-infective development, and natural product mining for anti-infective and anti-proliferative product discovery. This article will focus on the extent to which current mycological research can be exploited for novel therapeutic advantage and examines the challenges involved in maximizing the translational potential of such research.

Journal article

Jamal A, Bignell EM, Coutts RHA, 2010, Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus, VIRUS RESEARCH, Vol: 153, Pages: 64-70, ISSN: 0168-1702

Journal article

Cairns T, Minuzzi F, Bignell E, 2010, The host-infecting fungal transcriptome, FEMS MICROBIOLOGY LETTERS, Vol: 307, Pages: 1-11, ISSN: 0378-1097

Journal article

Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DPet al., 2010, Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies, MEDICAL MYCOLOGY, Vol: 48, Pages: 506-510, ISSN: 1369-3786

Journal article

Han K-H, Chun Y-H, Pimentel Figueiredo BDC, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, Goldman MHS, Kim J-H, Bahn Y-S, Goldman GH, da Silva Ferreira MEet al., 2010, The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (vol 75, pg 1372, 2010), MOLECULAR MICROBIOLOGY, Vol: 76, Pages: 802-802, ISSN: 0950-382X

Journal article

Bignell E, 2010, Aspergillus: Molecular Biology and Genomics. By Masayuki Machida and Katsuya Gomi (Eds.)., Biotechnol J, Vol: 5, Pages: 336-337, ISSN: 1860-7314

no abstract.

Journal article

Han K-H, Chun Y-H, Pimentel Figueiredo BDC, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, Goldman MHS, Kim J-H, Bahn Y-S, Goldman GH, da Silva Ferreira MEet al., 2010, The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans, MOLECULAR MICROBIOLOGY, Vol: 75, Pages: 1372-1388, ISSN: 0950-382X

Journal article

Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes Ket al., 2009, Impaired Interferon-gamma Responses, Increased Interleukin-17 Expression, and a Tumor Necrosis Factor-alpha Transcriptional Program in Invasive Aspergillosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 200, Pages: 1341-1351, ISSN: 0022-1899

Journal article

Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann Set al., 2009, A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence, INFECTION AND IMMUNITY, Vol: 77, Pages: 4041-4050, ISSN: 0019-9567

Journal article

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell Eet al., 2008, Sub-telomere directed gene expression during initiation of invasive aspergillosis, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366

Journal article

de Gouvea PF, Soriani FM, Malavazi I, Savoldi M, de Souza Goldman MH, Loss O, Bignell E, da Silva Ferreira ME, Goldman GHet al., 2008, Functional characterization of the Aspergillus fumigatus PHO80 homologue, FUNGAL GENETICS AND BIOLOGY, Vol: 45, Pages: 1135-1146, ISSN: 1087-1845

Journal article

Penalva MA, Tilburn J, Bignell E, Arst HNet al., 2008, Ambient pH gene regulation in fungi: making connections, TRENDS IN MICROBIOLOGY, Vol: 16, Pages: 291-300, ISSN: 0966-842X

Journal article

Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann Set al., 2008, Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis, FUNGAL GENETICS AND BIOLOGY, Vol: 45, Pages: 693-704, ISSN: 1087-1845

Journal article

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