Summary
Dr Edward Chambers is a Non-Clinical Lecturer in the Nutrition and Dietetics Research Group. His applied in vivo human research aims to advance understanding of nutritional intervention in health and disease.
His main area of interest is investigating the interplay between dietary fibre and the composition and functional activities of the gut microbiome in the regulation of metabolic homeostasis in humans. At Imperial College London, his principal responsibility has been the conduct and management of BBSRC and NIHR BRC funded projects which have investigated the beneficial role of the gut-derived short chain fatty acid (SCFA) propionate to metabolic health. Published studies have developed in vivo proof-of-concept for propionate as a novel therapeutic to improve body weight management and reduce hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD).
Publications
Journals
Lu H, George J, Eslam M, et al., 2023, Discriminatory changes in circulating metabolites as a predictor of hepatocellular cancer in patients with MAFLD, Liver Cancer, Vol:12, ISSN:2235-1795, Pages:19-31
Garcia-Perez I, Posma JM, Chambers ES, et al., 2023, Dietary metabotype modelling predicts individual responses to dietary interventions (Vol 1, pg 355, 2020) (Retraction of Vol 1, Pg 355, 2020), Nature Food
Chew W, Lim YP, Lim WS, et al., 2023, Gut-muscle crosstalk. A perspective on influence of microbes on muscle function, Frontiers in Medicine, Vol:9
Brignardello J, Fountana S, Posma JM, et al., 2022, Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: a randomized crossover dietary trial, The American Journal of Clinical Nutrition, Vol:116, ISSN:0002-9165, Pages:1368-1378
Frampton J, Izzi-Engbeaya C, Salem V, et al., 2022, The acute effect of glucagon on components of energy balance and glucose homoeostasis in adults without diabetes: a systematic review and meta-analysis, International Journal of Obesity, Vol:46, ISSN:0307-0565, Pages:1948-1959