Imperial College London
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DrEdwardChambers

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer
 
 
 
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Contact

 

e.chambers

 
 
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Location

 

10.N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chambers:2019:10.1111/dom.13500,
author = {Chambers, E and Byrne, C and Rugyendo, A and Morrison, D and Preston, T and Tedford, C and Bell, J and Thomas, L and Akbar, A and Riddell, N and Sharma, R and Thursz, M and Manousou, P and Frost, G},
doi = {10.1111/dom.13500},
journal = {Diabetes, Obesity and Metabolism},
pages = {372--376},
title = {The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease},
url = {http://dx.doi.org/10.1111/dom.13500},
volume = {21},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with nonalcoholic fatty liver disease (NAFLD). Eighteen adults were randomised to receive 20g/day of an inulinpropionate ester (IPE), designed to deliver propionate to the colon, or an inulincontrol for 42days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between groups (P=0.082), however IHCL significantly increased within the inulincontrol group (20.9±2.9 to 26.8±3.9%; P=0.012; n=9), which was not observed within the IPE group (22.6±6.9 to 23.5±6.8%; P=0.635; n=9). The predominant SCFA from colonic fermentation of inulin is acetate, which in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetatemediated increase in IHCL.
AU  - Chambers,E
AU  - Byrne,C
AU  - Rugyendo,A
AU  - Morrison,D
AU  - Preston,T
AU  - Tedford,C
AU  - Bell,J
AU  - Thomas,L
AU  - Akbar,A
AU  - Riddell,N
AU  - Sharma,R
AU  - Thursz,M
AU  - Manousou,P
AU  - Frost,G
DO  - 10.1111/dom.13500
EP  - 376
PY  - 2019///
SN  - 1462-8902
SP  - 372
TI  - The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease
T2  - Diabetes, Obesity and Metabolism
UR  - http://dx.doi.org/10.1111/dom.13500
UR  - http://hdl.handle.net/10044/1/61956
VL  - 21
ER  -
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