Imperial College London
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DrEdwardChambers

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer
 
 
 
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Contact

 

e.chambers

 
 
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Location

 

10.N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Frampton:2021:10.1007/s40279-021-01473-2,
author = {Frampton, J and Cobbold, B and Nozdrin, M and Oo, HTH and Wilson, H and Murphy, KG and Frost, G and Chambers, ES},
doi = {10.1007/s40279-021-01473-2},
journal = {Sports Medicine},
pages = {1949--1966},
title = {The effect of a single bout of continuous aerobic exercise on glucose, insulin and glucagon concentrations compared to resting conditions in healthy adults: a systematic review, meta-analysis and meta-regression},
url = {http://dx.doi.org/10.1007/s40279-021-01473-2},
volume = {51},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Elevated glucose and insulin levels are major risk factors in the development of cardiometabolic disease. Aerobic exercise is widely recommended to improve glycaemic control, yet its acute effect on glycaemia and glucoregulatory hormones has not been systematically reviewed and analysed in healthy adults.Objective:To determine the effect of a single bout of continuous aerobic exercise on circulating glucose, insulin, and glucagon concentrations in healthy adults.Methods:CENTRAL, CINAHL, Embase, Global Health, HMIC, Medline, PubMed, PsycINFO, ScienceDirect, Scopus and Web of Science databases were searched from inception to May 2020. Papers were included if they reported a randomised, crossover study measuring glucose and/or insulin and/or glucagon concentrations before and immediately after a single bout of continuous aerobic exercise (≥ 30 min) compared to a time-matched, resting control arm in healthy adults. The risk of bias and quality of evidence were assessed using the Cochrane Risk of Bias Tool and GRADE approach, respectively. Random-effects meta-analyses were performed for glucose, insulin, and glucagon. Sub-group meta-analyses and meta-regression were performed for categorical (metabolic state [postprandial or fasted], exercise mode [cycle ergometer or treadmill]) and continuous (age, body mass index, % males, maximal aerobic capacity, exercise duration, exercise intensity) covariates, respectively.Results42 papers (51 studies) were considered eligible: glucose (45 studies, 391 participants), insulin (38 studies, 377 participants) and glucagon (5 studies, 47 participants). Acute aerobic exercise had no significant effect on glucose concentrations (mean difference: − 0.05 mmol/L; 95% CI, − 0.22 to 0.13 mmol/L; P = 0.589; I2: 91.08%, large heterogeneity; moderate-quality evidence). Acute aerobic exercise significantly decreased insulin concentrations (mean difference: − 18.07 pmol/L; 95% CI, − 30.47
AU  - Frampton,J
AU  - Cobbold,B
AU  - Nozdrin,M
AU  - Oo,HTH
AU  - Wilson,H
AU  - Murphy,KG
AU  - Frost,G
AU  - Chambers,ES
DO  - 10.1007/s40279-021-01473-2
EP  - 1966
PY  - 2021///
SN  - 0112-1642
SP  - 1949
TI  - The effect of a single bout of continuous aerobic exercise on glucose, insulin and glucagon concentrations compared to resting conditions in healthy adults: a systematic review, meta-analysis and meta-regression
T2  - Sports Medicine
UR  - http://dx.doi.org/10.1007/s40279-021-01473-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000644734400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs40279-021-01473-2
UR  - http://hdl.handle.net/10044/1/89456
VL  - 51
ER  -
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