Imperial College London
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DrEdwardChambers

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer
 
 
 
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Contact

 

e.chambers

 
 
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Location

 

10.N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Frampton:2022:10.1038/s41366-022-01223-y,
author = {Frampton, J and Izzi-Engbeaya, C and Salem, V and Murphy, KG and Tan, TM and Chambers, ES},
doi = {10.1038/s41366-022-01223-y},
journal = {International Journal of Obesity},
pages = {1948--1959},
title = {The acute effect of glucagon on components of energy balance and glucose homoeostasis in adults without diabetes: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1038/s41366-022-01223-y},
volume = {46},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveUsing a systematic review and meta-analysis, we aimed to estimate the mean effect of acute glucagon administration on components of energy balance and glucose homoeostasis in adults without diabetes.MethodsCENTRAL, CINAHL, Embase, MEDLINE, PubMed, and Scopus databases were searched from inception to May 2021. To be included, papers had to be a randomised, crossover, single- or double-blind study, measuring ad libitum meal energy intake, energy expenditure, subjective appetite, glucose, and/or insulin following acute administration of glucagon and an appropriate comparator in adults without diabetes. Risk of bias was assessed using the Revised Cochrane Risk of Bias Tool for Randomized trials with additional considerations for cross-over trials. Certainty of evidence was assessed using the GRADE approach. Random-effect meta-analyses were performed for outcomes with at least five studies. This study is registered on PROSPERO (CRD42021269623).ResultsIn total, 13 papers (15 studies) were considered eligible: energy intake (5 studies, 77 participants); energy expenditure (5 studies, 59 participants); subjective appetite (3 studies, 39 participants); glucose (13 studies, 159 participants); insulin (12 studies, 147 participants). All studies had some concerns with regards to risk of bias. Mean intervention effect of acute glucagon administration on energy intake was small (standardised mean difference [SMD]: –0.19; 95% CI, –0.59 to 0.21; P = 0.345). Mean intervention effect of acute glucagon administration on energy expenditure (SMD: 0.72; 95% CI, 0.37–1.08; P < 0.001), glucose (SMD: 1.11; 95% CI, 0.60–1.62; P < 0.001), and insulin (SMD: 1.33; 95% CI, 0.88–1.77; P < 0.001) was moderate to large.ConclusionsAcute glucagon administration produces substantial increases in energy expenditure, and in circulating insulin and glucose concentrations. However, the effect of acute g
AU  - Frampton,J
AU  - Izzi-Engbeaya,C
AU  - Salem,V
AU  - Murphy,KG
AU  - Tan,TM
AU  - Chambers,ES
DO  - 10.1038/s41366-022-01223-y
EP  - 1959
PY  - 2022///
SN  - 0307-0565
SP  - 1948
TI  - The acute effect of glucagon on components of energy balance and glucose homoeostasis in adults without diabetes: a systematic review and meta-analysis
T2  - International Journal of Obesity
UR  - http://dx.doi.org/10.1038/s41366-022-01223-y
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000857854300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41366-022-01223-y
UR  - http://hdl.handle.net/10044/1/99623
VL  - 46
ER  -
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