Imperial College London
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DrEdwardChambers

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer
 
 
 
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Contact

 

e.chambers

 
 
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Location

 

10.N4Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chambers:2017:10.1111/dom.13159,
author = {Chambers, E and Frost, G and Byrne, C and Aspey, K and Khan, S and Chen, Y and Morrison, D},
doi = {10.1111/dom.13159},
journal = {Diabetes, Obesity and Metabolism},
pages = {1034--1039},
title = {Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans},
url = {http://dx.doi.org/10.1111/dom.13159},
volume = {20},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Shortchain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models has demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of the present study was to investigate the effects of oral sodium propionate on REE and substrate metabolism in humans. Eighteen healthy volunteers (9 women and 9 men; age 25 ± 1 years; body mass index 24.1 ± 1.2 kg/m2) completed 2 study visits following an overnight fast. Tablets containing a total of 6845 mg sodium propionate or 4164 mg sodium chloride were provided over the 180minute study period in random order. REE and substrate oxidation were assessed by indirect calorimetry. Oral sodium propionate administration increased REE (0.045 ± 0.020 kcal/min; P = .036); this was accompanied by elevated rates of wholebody lipid oxidation (0.012 ± 0.006 g/min; P = .048) and was independent of changes in glucose and insulin concentrations. Future studies are warranted to determine whether the acute effects of oral sodium propionate on REE translate into positive improvements in longterm energy balance in humans.
AU  - Chambers,E
AU  - Frost,G
AU  - Byrne,C
AU  - Aspey,K
AU  - Khan,S
AU  - Chen,Y
AU  - Morrison,D
DO  - 10.1111/dom.13159
EP  - 1039
PY  - 2017///
SN  - 1462-8902
SP  - 1034
TI  - Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans
T2  - Diabetes, Obesity and Metabolism
UR  - http://dx.doi.org/10.1111/dom.13159
UR  - http://hdl.handle.net/10044/1/53486
VL  - 20
ER  -
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