Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cunnea:2018:10.1038/s41598-018-32720-8,
author = {Cunnea, P and Gorgy, T and Petkos, K and Gowers, S and Lu, H and Morera, C and Wu, W and Lawton, P and Nixon, K and Leong, C and Sorbi, F and Domenici, L and Paterson, A and Curry, E and Gabra, H and Boutelle, M and Drakakis, E and Fotopoulou, C},
doi = {10.1038/s41598-018-32720-8},
journal = {Scientific Reports},
pages = {1--12},
title = {Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients},
url = {http://dx.doi.org/10.1038/s41598-018-32720-8},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC). In this study, we suggest that profiling of tumour parameters such as bioelectrical-potential and metabolites, detectable by electronic sensors, could facilitate the future development of devices to better monitor disease and predict surgical and treatment outcomes. Biopotential was recorded, using a potentiometric measurement system, in ex vivo paired non-cancerous and cancerous omental tissues from advanced stage EOC (n = 36), and lysates collected for metabolite measurement by microdialysis. Consistently different biopotential values were detected in cancerous tissue versus non-cancerous tissue across all cases (p < 0.001). High tumour biopotential levels correlated with advanced tumour stage (p = 0.048) and tumour load, and negatively correlated with stroma. Within our EOC cohort and specifically the high-grade serous subtype, low biopotential levels associated with poorer progression-free survival (p = 0.0179, p = 0.0143 respectively). Changes in biopotential levels significantly correlated with common apoptosis related pathways. Lactate and glucose levels measured in paired tissues showed significantly higher lactate/glucose ratio in tissues with low biopotential (p < 0.01, n = 12). Our study proposes the feasibility of biopotential and metabolite monitoring as a biomarker modality profiling EOC to predict surgical and clinical outcomes.
AU  - Cunnea,P
AU  - Gorgy,T
AU  - Petkos,K
AU  - Gowers,S
AU  - Lu,H
AU  - Morera,C
AU  - Wu,W
AU  - Lawton,P
AU  - Nixon,K
AU  - Leong,C
AU  - Sorbi,F
AU  - Domenici,L
AU  - Paterson,A
AU  - Curry,E
AU  - Gabra,H
AU  - Boutelle,M
AU  - Drakakis,E
AU  - Fotopoulou,C
DO  - 10.1038/s41598-018-32720-8
EP  - 12
PY  - 2018///
SN  - 2045-2322
SP  - 1
TI  - Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-32720-8
UR  - https://www.nature.com/articles/s41598-018-32720-8
UR  - http://hdl.handle.net/10044/1/64682
VL  - 8
ER  -
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