Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soleimani:2018:10.1002/cta.2514,
author = {Soleimani, H and Drakakis, EM},
doi = {10.1002/cta.2514},
journal = {International Journal of Circuit Theory and Applications},
pages = {1929--1939},
title = {A low-power digital IC emulating intracellular calcium dynamics},
url = {http://dx.doi.org/10.1002/cta.2514},
volume = {46},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Low power/area cytomorphic chips may be interfaced and ultimately implanted in the human body for cellsensing and cellcontrol applications of the future. In such electronic platforms, it is crucial to accurately mimic the biological timescales and operate in real time. This paper proposes a methodology where slow nonlinear dynamical systems describing the behaviour of naturally encountered biological systems can be efficiently realised in hardware. To this end, as a case study, a low power and efficient digital ApplicationSpecific Integrated Circuit capable of emulating slow intracellular calcium dynamics with timescales reaching to seconds has been fabricated in the commercially available AMS 0.35 μm technology and compared with its analog counterpart. The fabricated chip occupies an area of 1.5 mm2 (excluding the area of the pads) and consumes 18.93 nW for each calcium unit from a power supply of 3.3 V. The presented cytomimetic topology follows closely the behaviour of its biological counterpart, exhibiting similar timedomain calcium ions dynamics. Results show that the implemented design has the potential to speed up large–scale simulations of slow intracellular dynamics by sharing cellular units in real time.
AU  - Soleimani,H
AU  - Drakakis,EM
DO  - 10.1002/cta.2514
EP  - 1939
PY  - 2018///
SN  - 0098-9886
SP  - 1929
TI  - A low-power digital IC emulating intracellular calcium dynamics
T2  - International Journal of Circuit Theory and Applications
UR  - http://dx.doi.org/10.1002/cta.2514
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448848300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66135
VL  - 46
ER  -
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