Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Petkos:2019:1741-2552/ab2610,
author = {Petkos, K and Guiho, T and Degenaar, P and Jackson, A and Brown, P and Denison, TJ and Drakakis, EM},
doi = {1741-2552/ab2610},
journal = {Journal of Neural Engineering},
title = {A high-performance 4 nV (√Hz)−1 analog front-end architecture for artefact suppression in local field potential recordings during deep brain stimulation},
url = {http://dx.doi.org/10.1088/1741-2552/ab2610},
volume = {16},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective. Recording of local field potentials (LFPs) during deep brain stimulation (DBS) is necessary to investigate the instantaneous brain response to stimulation, minimize time delays for closed-loop neurostimulation and maximise the available neural data. To our knowledge, existing recording systems lack the ability to provide artefact-free high-frequency (>100 Hz) LFP recordings during DBS in real time primarily because of the contamination of the neural signals of interest by the stimulation artefacts. Approach. To solve this problem, we designed and developed a novel, low-noise and versatile analog front-end (AFE) that uses a high-order (8th) analog Chebyshev notch filter to suppress the artefacts originating from the stimulation frequency. After defining the system requirements for concurrent LFP recording and DBS artefact suppression, we assessed the performance of the realised AFE by conducting both in vitro and in vivo experiments using unipolar and bipolar DBS (monophasic pulses, amplitude ranging from 3 to 6 V peak-to-peak, frequency 140 Hz and pulse width 100 µs). A full performance comparison between the proposed AFE and an identical AFE, equipped with an 8th order analog Bessel notch filter, was also conducted. Main results. A high-performance, 4 nV (√Hz)−1 AFE that is capable of recording nV-scale signals was designed in accordance with the imposed specifications. Under both in vitro and in vivo experimental conditions, the proposed AFE provided real-time, low-noise and artefact-free LFP recordings (in the frequency range 0.5–250 Hz) during stimulation. Its sensing and stimulation artefact suppression capabilities outperformed the capabilities of the AFE equipped with the Bessel notch filter. Significance. The designed AFE can precisely record LFP signals, in and without the presence of either unipolar or bipolar DBS, which renders it as a functional and practical AFE architecture to be utilised in a wide range of applica
AU  - Petkos,K
AU  - Guiho,T
AU  - Degenaar,P
AU  - Jackson,A
AU  - Brown,P
AU  - Denison,TJ
AU  - Drakakis,EM
DO  - 1741-2552/ab2610
PY  - 2019///
SN  - 1741-2552
TI  - A high-performance 4 nV (√Hz)−1 analog front-end architecture for artefact suppression in local field potential recordings during deep brain stimulation
T2  - Journal of Neural Engineering
UR  - http://dx.doi.org/10.1088/1741-2552/ab2610
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31151118
UR  - https://iopscience.iop.org/article/10.1088/1741-2552/ab2610
UR  - http://hdl.handle.net/10044/1/70564
VL  - 16
ER  -
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