Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soleimani:2017:10.1109/TBCAS.2016.2636183,
author = {Soleimani, H and Drakakis, EM},
doi = {10.1109/TBCAS.2016.2636183},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {703--713},
title = {A compact synchronous cellular model of nonlinear calcium dynamics: simulation and FPGA synthesis results},
url = {http://dx.doi.org/10.1109/TBCAS.2016.2636183},
volume = {11},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Recent studies have demonstrated that calcium is a widespread intracellular ion that controls a widerange of temporal dynamics in the mammalian body. The simulation and validation of such studies us-ing experimental data would bene t from a fast large scale simulation and modelling tool. This paperpresents a compact and fully recon gurable cellular calcium model capable of mimicking Hopf bifurcationphenomenon and various nonlinear responses of the biological calcium dynamics. The proposed cellularmodel is synthesized on a digital platform for a single unit and a network model. Hardware synthesis,physical implementation on FPGA, and theoretical analysis con rm that the proposed cellular model canmimic the biological calcium behaviors with considerably low hardware overhead. The approach has thepotential to speed up large{scale simulations of slow intracellular dynamics by sharing more cellular unitsin real{time. To this end, various networks constructed by pipelining 10k to 40k cellular calcium units arecompared with an equivalent simulation run on a standard PC workstation. Results show that the cellularhardware model is, on average, 83 times faster than the CPU version.
AU  - Soleimani,H
AU  - Drakakis,EM
DO  - 10.1109/TBCAS.2016.2636183
EP  - 713
PY  - 2017///
SN  - 1932-4545
SP  - 703
TI  - A compact synchronous cellular model of nonlinear calcium dynamics: simulation and FPGA synthesis results
T2  - IEEE Transactions on Biomedical Circuits and Systems
UR  - http://dx.doi.org/10.1109/TBCAS.2016.2636183
UR  - http://hdl.handle.net/10044/1/44423
VL  - 11
ER  -
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