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@article{Boutelle:2018:10.1039/C7AN01209H,
author = {Boutelle, MG and Gowers, SAN and Hamaoui, K and Cunnea, P and Anastasova-Ivanova, S and Curto, VF and Vadgama, P and Yang, G-Z and Papalois, V and Drakakis, EM and Weber, SG and Boutelle, MG},
doi = {10.1039/C7AN01209H},
journal = {Analyst},
pages = {715--724},
title = {High temporal resolution delayed analysis of clinical microdialysate streams},
url = {http://dx.doi.org/10.1039/C7AN01209H},
volume = {143},
year = {2018}
}

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TY  - JOUR
AB  - This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. Samples stored in this way were found to be stable for up to 72 days at −80 °C. Examples of how this methodology can be applied to glucose and lactate measurement in a wide range of in vivo monitoring experiments are presented. This paper presents a general model, which allows for an informed choice of tubing parameters for a given storage time and flow rate avoiding high back pressure, which would otherwise cause the microdialysis probe to leak, while maximising temporal resolution.
AU  - Boutelle,MG
AU  - Gowers,SAN
AU  - Hamaoui,K
AU  - Cunnea,P
AU  - Anastasova-Ivanova,S
AU  - Curto,VF
AU  - Vadgama,P
AU  - Yang,G-Z
AU  - Papalois,V
AU  - Drakakis,EM
AU  - Weber,SG
AU  - Boutelle,MG
DO  - 10.1039/C7AN01209H
EP  - 724
PY  - 2018///
SN  - 1364-5528
SP  - 715
TI  - High temporal resolution delayed analysis of clinical microdialysate streams
T2  - Analyst
UR  - http://dx.doi.org/10.1039/C7AN01209H
UR  - http://hdl.handle.net/10044/1/51964
VL  - 143
ER  -

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