Imperial College London
Alternate

ProfessorEmm MicDrakakis

Faculty of Engineering, Department of Bioengineering

Professor of Bio-Circuits and Systems
 
 
 
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Contact

 

e.drakakis Website

 
 
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Location

 

B207Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pagkalos:2018:10.1002/cphc.201701119,
author = {Pagkalos, I and Rogers, M and Boutelle, MG and Drakakis, EM},
doi = {10.1002/cphc.201701119},
journal = {ChemPhysChem: a European journal of chemical physics and physical chemistry},
pages = {1215--1225},
title = {A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring},
url = {http://dx.doi.org/10.1002/cphc.201701119},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This paper presents the first application specific integrated chip (ASIC) for the monitoring of patients who have suffered a Traumatic Brain Injury (TBI). By monitoring the neuralphysiological (ECoG) and neurochemical (glucose, lactate and potassium) signals of the injured human brain tissue, it is possible to detect spreading depolarisations, which have been shown to be associated with poor TBI patient outcome. This paper describes the testing of a new 7.5mm2 ASIC fabricated in the commercially available AMS 0.35μm CMOS technology. The ASIC has been designed to meet the demands of processing the injured brain tissue's ECoG signals, recorded by means of depth or brain surface electrodes, and neurochemical signals, recorded using microdialysis coupled to microfluidics-based electrochemical biosensors. The potentiostats use switched-capacitor charge integration to record currents with 100fA resolution, and allow automatic gain changing to track the falling sensitivity of a biosensor. This work supports the idea of a "behind the ear" wireless microplatform modality, which could enable the monitoring of currently non-monitored mobile TBI patients for the onset of secondary brain injury.
AU  - Pagkalos,I
AU  - Rogers,M
AU  - Boutelle,MG
AU  - Drakakis,EM
DO  - 10.1002/cphc.201701119
EP  - 1225
PY  - 2018///
SN  - 1439-4235
SP  - 1215
TI  - A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring
T2  - ChemPhysChem: a European journal of chemical physics and physical chemistry
UR  - http://dx.doi.org/10.1002/cphc.201701119
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29388305
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cphc.201701119
UR  - http://hdl.handle.net/10044/1/57007
VL  - 19
ER  -
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