Publications
91 results found
Grace MS, Dubuis E, Birrell MA, et al., 2012, TRP Channel Antagonists as Potential Antitussives, LUNG, Vol: 190, Pages: 11-15, ISSN: 0341-2040
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- Citations: 14
Thompson V, Dubuis E, Leite MI, et al., 2011, Patients with complex regional pain syndrome have activating serum-autoantibodies against alpha 1 adrenoceptors and muscarinergic receptors, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 153-153, ISSN: 0019-2805
Belvisi MG, Dubuis E, Birrell MA, 2011, Transient Receptor Potential A1 Channels Insights Into Cough and Airway Inflammatory Disease, CHEST, Vol: 140, Pages: 1040-1047, ISSN: 0012-3692
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- Citations: 54
Maher SA, Dubuis ED, Belvisi MG, 2011, G-protein coupled receptors regulating cough, CURRENT OPINION IN PHARMACOLOGY, Vol: 11, Pages: 248-253, ISSN: 1471-4892
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- Citations: 34
Dutt T, Dubuis E, Perez-Casal M, et al., 2009, Activated protein C regulates cardiomyocyte function via EPCR and PAR1, Publisher: ELSEVIER SCIENCE INC, Pages: 999-999, ISSN: 1538-7933
Sodi R, Dubuis E, Shenkin A, et al., 2008, B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function, REGULATORY PEPTIDES, Vol: 151, Pages: 95-105, ISSN: 0167-0115
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- Citations: 18
Dubuis E, 2007, DHEA treatment of pulmonary hypertension: New insights into a complex mechanism, CARDIOVASCULAR RESEARCH, Vol: 74, Pages: 337-338, ISSN: 0008-6363
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- Citations: 2
Elkadri M, Dubuis E, Hart G, et al., 2007, Effects of changes in unitary Ca<SUP>2+</SUP> current on Ca<SUP>2+</SUP>-induced Ca<SUP>2+</SUP>-release from the sarcoplasmic reticulum, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S19-S19, ISSN: 0022-2828
Dubuis E, Bracken N, Hart G, et al., 2007, Inhibitory effect of 4-iodopropofol on I<sub>NA</sub> is associated with accelerated voltage-dependent inactivation, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S15-S16, ISSN: 0022-2828
Dubuis E, Rockliffe N, Hussain M, et al., 2006, c-Src-mediated phosphorylation of cardiac L-type Ca<SUP>2+</SUP> channel regulates <i>I</i><sub>Ca</sub> through multiple binding sites, 28th Annual International-Society-for-Heart-Research North American Section Meeting, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 986-986, ISSN: 0022-2828
Bracken N, Dubuis E, Haeseler G, et al., 2006, Halogenated phenol derivatives inhibit the fast sodium current (<i>I</i><sub>Na</sub>) with differential potency in rat ventricular myocytes, 28th Annual International-Society-for-Heart-Research North American Section Meeting, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 985-985, ISSN: 0022-2828
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- Citations: 1
Dubuis E, Rockliffe N, Hussain M, et al., 2006, Evidence for multiple Src binding sites on the α1c L-type Ca<SUP>2+</SUP> channel and their roles in activity regulation, CARDIOVASCULAR RESEARCH, Vol: 69, Pages: 391-401, ISSN: 0008-6363
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- Citations: 26
Dubuis E, Potier M, Wang R, et al., 2005, Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BK<sub>Ca</sub> channels, CARDIOVASCULAR RESEARCH, Vol: 65, Pages: 751-761, ISSN: 0008-6363
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- Citations: 59
Dubuis E, Kumar P, Gautier M, et al., 2004, Acidosis abolishes the effect of repeated applications of ATP on pulmonary artery force and [Ca<SUP>2+</SUP>]<i><sub>i</sub></i>, RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, Vol: 141, Pages: 157-166, ISSN: 1569-9048
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- Citations: 1
Rui WMD, 2004, Signal transduction and the gasotransmitters, Signal transduction and the gasotransmitters, Editors: Rui, Publisher: Humana Pr Inc, ISBN: 9781588293497
Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in ...
Dubuis E, Kumar P, Bonnet P, et al., 2004, Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells, Signal Transduction and the Gasotransmitters, Publisher: Humana Press, Pages: 259-272, ISBN: 9781617375125
Bonnet S, Savineau JP, Barillot W, et al., 2003, Role of Ca<SUP>2+</SUP>-sensitive K<SUP>+</SUP> channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases, CARDIOVASCULAR RESEARCH, Vol: 60, Pages: 326-336, ISSN: 0008-6363
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- Citations: 25
Melin A, Fauchier L, Dubuis E, et al., 2003, Heart rate variability in rats acclimatized to high altitude, HIGH ALTITUDE MEDICINE & BIOLOGY, Vol: 4, Pages: 375-387, ISSN: 1527-0297
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- Citations: 12
Dubuis E, Gautier M, Melin A, et al., 2003, Chronic carbon monoxide exposure of hypoxic rats increases in vitro sensitivity of pulmonary artery smooth muscle, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, Vol: 81, Pages: 711-719, ISSN: 0008-4212
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- Citations: 2
Kumar P, Dubuis E, Vandier C, 2003, Regulation of K<SUP>+</SUP> currents by CO in carotid body type I cells and pulmonary artery smooth muscle cells, CHEMORECEPTION: FROM CELLULAR SIGNALLING TO FUNCTIONAL PLASTICITY, Vol: 536, Pages: 147-154, ISSN: 0065-2598
Bonnet S, Dubuis E, Vandier C, et al., 2002, Reversal of chronic hypoxia-induced alteration in K<sub>Ca</sub> channels in pulmonary artery smooth muscle cells upon air breathing, Meeting of the Physiological-Society, Publisher: CAMBRIDGE UNIV PRESS, Pages: 23P-23P, ISSN: 0022-3751
Barbé C, Al-Hashem F, Conway AF, et al., 2002, A possible dual site of action for carbon monoxide-mediated chemoexcitation in the rat carotid body, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 543, Pages: 933-945, ISSN: 0022-3751
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- Citations: 21
Dubuis E, Gautier M, Melin A, et al., 2002, Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 283, Pages: L120-L129, ISSN: 1040-0605
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- Citations: 12
Barbé C, Dubuis E, Rochetaing A, et al., 2002, A 4-AP-sensitive current is enhanced by chronic carbon monoxide exposure in coronary artery myocytes, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 282, Pages: H2031-H2038, ISSN: 0363-6135
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- Citations: 12
Bonnet S, Dubuis E, Vandier C, et al., 2002, Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing, CARDIOVASCULAR RESEARCH, Vol: 53, Pages: 1019-1028, ISSN: 0008-6363
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- Citations: 23
Dubuis E, Gautier M, Melin A, et al., 2002, Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol: 283, ISSN: 1040-0605
Exogenous carbon monoxide (CO) can induce pulmonary vasodilation by acting directly on pulmonary artery (PA) smooth muscle cells. We investigated the contribution of K+ channels to the regulation of resistance PA resting membrane potential on control (PAC) rats and rats exposed to CO for 3 wk at 530 parts/million, labeled as PACO rats. Whole cell patch-clamp experiments revealed that the resting membrane potential of PACO cells was more negative than that of PAC cells. This was associated with a decrease of membrane resistance in PACO cells. Additional analysis showed that outward current density in PACO cells was higher (50% at +60 mV) than in PAC cells. This was linked to an increase of iberiotoxin (IbTx)-sensitive current. Chronic CO hyperpolarized membrane of pressurized PA from -46.9 ± 1.2 to -56.4 ± 2.6 mV. Additionally, IbTx significantly depolarized membrane of smooth muscle cells from PACO arteries but not from PAC arteries. The present study provides initial evidence of an increase of Ca2+-activated K- current in smooth muscle cells from PA of rats exposed to chronic CO.
Barbé C, Dubuis E, Rochetaing A, et al., 2002, A 4-AP-sensitive current is enhanced by chronic carbon monoxide exposure in coronary artery myocytes, American Journal of Physiology - Heart and Circulatory Physiology, Vol: 282, ISSN: 0363-6135
A physiological role of carbon monoxide has been suggested for coronary myocytes; however, direct evidence is lacking. The objective of this study was to test the effect of chronic carbon monoxide exposure on the K+ currents of the coronary myocytes. The effect of 3-wk chronic exposure to carbon monoxide was assessed on K+ currents in isolated rat left coronary myocytes by the use of the patch-clamp technique in the whole cell configuration. Moreover, membrane potential studies were performed on coronary artery rings using intracellular microelectrodes, and coronary blood flow in isolated heart preparation was recorded. Carbon monoxide did not change the amplitude of global whole cell K+ current, but it did increase the component sensitive to 1 mM 4-aminopyridine. Carbon monoxide exposure hyperpolarized coronary artery segments by ∼10 mV and, therefore, increased their sensitivity to 4-aminopyridine. This effect was associated with an enhancement of coronary blood flow. We conclude that chronic carbon monoxide increases a 4-aminopyridinesensitive current in isolated coronary myocytes. This mechanism could, in part, contribute to hyperpolarization and to increased coronary blood flow observed with carbon monoxide.
De Crescenzo V, Dubuis E, Constantin S, et al., 2001, Halothane differentially decreases 5-hydroxytryptamine-induced contractions in normal and chronic hypoxic rat pulmonary arteries, ACTA PHYSIOLOGICA SCANDINAVICA, Vol: 173, Pages: 247-255, ISSN: 0001-6772
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- Citations: 6
Bonnet P, Bonnet S, Dubuis E, et al., 2001, Reoxygenation enhanced iberiotoxin-sensitive current in chronic hypoxic rat pulmonary artery smooth muscle cells., CIRCULATION, Vol: 104, Pages: 403-403, ISSN: 0009-7322
Barbé C, Dubuis E, Vandier C, et al., 2001, Effect of carbon monoxide on whole-cell currents of the isolated rat carotid body type I cell, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 533, Pages: 108P-109P, ISSN: 0022-3751
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