Summary
Efstathios (Stathis) Giotis
Research Fellow
I graduated from the School of veterinary medicine (Aristotle University, Greece) in 2001, received my MSc in biotechnology in 2002 and PhD in microbiology in 2006 from the Ulster and Illinois State Universities. Since 2009, I worked in research projects in the UK and abroad and gained a broad experience in research involving animal infection models, zoonotic bacteria and viruses. Common denominators of my research are the focus on the interface of human-animal health and the use of transcriptomics technologies to answer scientific questions.
I joined Imperial College London in 2012 and my current expertise is cantered on 3 overlapping themes: a) the molecular basis of pathogenesis, b) the host range restrictions, and c) the immunomodulatory abilities of avian- and bat-borne viruses. Beyond these, I am fascinated by the remarkable variation of tropisms and possible clinical outcomes that flaviviruses display, despite their high degrees of genomic similarity.
Section of Virology
Faculty of Medicine
St Mary's Campus
Norfolk Place
London W2 1PG
Tel: 44 (0)20 759 49057
Email: e.giotis@imperial.ac.uk
Selected Publications
Journal Articles
Dulwich KL, Asfor AS, Gray AG, et al., 2019, The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein, Frontiers in Cellular and Infection Microbiology, ISSN:2235-2988
Giotis E, Montillet G, Pain B, et al., 2019, Chicken embryonic-stem cells are permissive to poxvirus recombinant vaccine vectors, Genes, Vol:10, ISSN:2073-4425
Carnell G, Giotis E, Grehan K, et al., 2018, The bat influenza H17N10 can be neutralized by broadly-neutralizing monoclonal antibodies and its neuraminidase can facilitate viral egress., Biorxiv
Giotis ES, Ross CS, Robey RC, et al., 2017, Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells, Scientific Reports, Vol:7, ISSN:2045-2322
Giotis ES, Robey RC, Skinner NG, et al., 2016, Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α), Veterinary Research, Vol:47, ISSN:1297-9716
Long JS, Giotis ES, Moncorgé O, et al., 2016, Species difference in ANP32A underlies influenza A virus polymerase host restriction, Nature, Vol:529, ISSN:0028-0836, Pages:101-104
Giotis ES, Rothwell L, Scott A, et al., 2015, Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model., PLOS One, Vol:10, ISSN:1932-6203, Pages:e0134866-e0134866
Ascough S, Sadeyen J-R, Giotis E, et al., 2014, Potentiating the immunogenicity of poxvirus vectors to improve the efficacy of live recombinant viral vaccines in poultry, Immunology, Vol:143, ISSN:0019-2805, Pages:66-66
Laidlaw SM, Robey R, Davies M, et al., 2013, Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon, Journal of Virology, Vol:87, ISSN:1098-5514