Imperial College London

ProfessorEdwardGregg

Faculty of MedicineSchool of Public Health

Chair in Diabetes and Cardiovascular Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3329e.gregg

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

394 results found

Holman N, Barron E, Young B, Gregg EW, Khunti K, Valabhji J, Sattar Net al., 2023, Comparative Incidence of Diabetes Following Hospital Admission for COVID-19 and Pneumonia: A Cohort Study., Diabetes Care, Vol: 46, Pages: 938-943

OBJECTIVE: The incidence of diabetes may be elevated following coronavirus disease 2019 (COVID-19), but it is unclear whether this is specific to severe acute respiratory syndrome coronavirus 2 infection, associated with shared risk factors for severe COVID-19 and diabetes, and/or a generic risk following illness. RESEARCH DESIGN AND METHODS: People admitted to the hospital for COVID-19 and/or pneumonia between 1 April 2020 and 31 August 2020 in England were linked with the National Diabetes Audit to identify incident diabetes after discharge up to 31 March 2021. Comparator cohorts admitted with pneumonia over the same dates in 2017, 2018, and 2019 were followed until 31 March 2018, 31 March 2019, and 31 March 2020, respectively. Poisson regression models were used to calculate adjusted diabetes incidence rates. RESULTS: Using the cohort of people discharged from the hospital following a diagnosis of COVID-19 without pneumonia in 2020 as the standard population (incidence rate 16.4 [95% CI 12.8-20.7] per 1,000 person-years), adjusting for age, sex, ethnicity, and deprivation, gave incidence rates of 19.0 (95% CI 13.8-25.6) and 16.6 (95% CI 13.3-20.4) per 1,000 person-years for those admitted for COVID-19 with pneumonia and pneumonia without COVID-19, respectively, in 2020. These rates are not significantly different from those found after hospital admission for pneumonia in 2019, 2018, and 2017, at 13.7 (95% CI 10.8-17.3), 13.8 (95% CI 10.9-17.4), and 14.2 (95% CI 10.9-18.3) per 1,000 person-years, respectively. CONCLUSIONS: Our data do not support a clear impact of COVID-19 on the incidence of diabetes compared with risks in several comparator groups, including contemporaneously assessed risks in people hospitalized with pneumonia.

Journal article

Holman N, Khunti K, Wild SH, Sattar N, Knighton P, Young B, Gregg EW, Bakhai C, Valabhji Jet al., 2022, Care processes in people in remission from type 2 diabetes: A cohort study using the National Diabetes Audit, DIABETIC MEDICINE, ISSN: 0742-3071

Journal article

Dasgupta K, Boule N, Henson J, Chevalier S, Redman E, Chan D, McCarthy M, Champagne J, Arsenyadis F, Rees J, Da Costa D, Gregg E, Yeung R, Hadjiconstantinou M, Dattani A, Friedrich MG, Khunti K, Rahme E, Fortier I, Prado CM, Sherman M, Thompson RB, Davies MJ, McCann GP, Yates Tet al., 2022, Remission of type 2 diabetes and improved diastolic function by combining structured exercise with meal replacement and food reintroduction among young adults: the RESET for REMISSION randomised controlled trial protocol, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Holman N, Wild SH, Khunti K, Knighton P, O'Keefe J, Bakhai C, Young B, Sattar N, Valabhji J, Gregg EWet al., 2022, Incidence and Characteristics of Remission of Type 2 Diabetes in England: A Cohort Study Using the National Diabetes Audit, DIABETES CARE, Vol: 45, Pages: 1151-1161, ISSN: 0149-5992

Journal article

Ruiz PLD, Chen L, Morton J, Salim A, Carstensen B, Gregg EW, Pavkov ME, Mata-Cases M, Mauricio D, Nichols GA, Santa P, Read SH, Wild SH, Shaw JE, Magliano DJet al., 2022, Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts, DIABETOLOGIA, Vol: 65, Pages: 964-972, ISSN: 0012-186X

Journal article

Davis WA, Chakera A, Gregg E, McAullay D, Davis TMEet al., 2022, Temporal Trends in Renal Replacement Therapy in Community-Based People with or without Type 2 Diabetes: The Fremantle Diabetes Study, JOURNAL OF CLINICAL MEDICINE, Vol: 11

Journal article

Holman N, Wild SH, Gregg EW, Valabhji J, Sattar N, Khunti Ket al., 2022, Comparison of mortality in people with type 1 and type 2 diabetes by age of diagnosis: an incident population-based study in England and Wales, LANCET DIABETES & ENDOCRINOLOGY, Vol: 10, Pages: 95-+, ISSN: 2213-8587

Journal article

Magliano DJ, Chen L, Carstensen B, Gregg EW, Pavkov ME, Salim A, Andes LJ, Balicer R, Baviera M, Chan JCN, Cheng YJ, Gardiner H, Gulseth HL, Gurevicius R, Ha KH, Jermendy G, Kim DJ, Kiss Z, Leventer-Roberts M, Chun-Yi L, Luk AOY, Ma S, Mata-Cases M, Mauricio D, Nichols GA, Pildava S, Porath A, Read SH, Robitaille C, Roncaglioni MC, Ruiz PL-D, Kang-Ling W, Wild SH, Yekutiel N, Shaw JEet al., 2022, Trends in all-cause mortality among people with diagnosed diabetes in high-income settings: a multicountry analysis of aggregate data, LANCET DIABETES & ENDOCRINOLOGY, Vol: 10, Pages: 112-119, ISSN: 2213-8587

Journal article

Rodriguez-Flores M, Goicochea-Turcott EW, Mancillas-Adame L, Garibay-Nieto N, Lopez-Cervantes M, Rojas-Russell ME, Castro-Porras L, Gutierrez-Leon E, Campos-Calderon LF, Pedraza-Escudero K, Aguilar-Cuarto K, Villanueva-Ortega E, Hernandez-Ruiz J, Guerrero-Avendano G, Monzalvo-Reyes SM, Garcia-Rascon R, Gil-Velazquez IN, Cortes-Hernandez DE, Granados-Shiroma M, Alvarez-Rodriguez BG, Cabello-Garza ML, Gonzalez-Contreras ZL, Picazo-Palencia E, Cerda-Arteaga JM, Perez-Gomez HR, Calva-Rodriguez R, Sanchez-Rodriguez G, Carpio-Vazquez LD, Davalos-Herrera MA, Villatoro-de-Pleitez KM, Suarez-Lopez MD, Nevarez-Carrillo MG, Perez-Alcantara K, Mehta R, Diez ES, Gregg EWet al., 2022, The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study, INTERNATIONAL JOURNAL OF OBESITY, Vol: 46, Pages: 661-668, ISSN: 0307-0565

Journal article

Knudsen JS, Knudsen SS, Hulman A, Witte DR, Gregg EW, Lauritzen T, Pedersen L, Sorensen HT, Thomsen RWet al., 2022, Changes in type 2 diabetes incidence and mortality associated with introduction of HbA1c as diagnostic option: A Danish 24-year population-based study, LANCET REGIONAL HEALTH-EUROPE, Vol: 14, ISSN: 2666-7762

Journal article

Pearson-Stuttard J, Cheng Y, Bennett J, Zhou B, Vamos E, Valabhji J, Cross A, Ezzati M, Gregg Eet al., 2022, Trends in leading causes of hospitalisation among adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records, The Lancet Diabetes and Endocrinology, Vol: 10, Pages: 46-57, ISSN: 2213-8595

BackgroundDiabetes mellitus (DM) leads to a wide range of established vascular and metabolic complications which has resulted in specific prevention programmes being implemented across high-income countries. DM has been associated with increased risk of a broader set of conditions including cancers, liver disease and common infections. We aimed to examine the trends in a broad set of cause-specific hospitalisations in individuals with DM in England from 2003-2018.MethodsWe identified 309,874 individuals with DM in the Clinical Practice Research Datalink, a well described primary care database, linked to Hospital Episode Statistics inpatient data from 2003-2018. We generated a mixed prevalence and incident DM study population through serial cross sections and follow-up over time. We used a discretised Poisson regression model to estimate annual cause-specific hospitalisation rates in men and women with DM across 17 cause groupings. We generated a 1:1 age and sex matched non-DM population to compare findings. FindingsHospitalisation rates were higher for all causes in persons with DM compared to those without throughout the study period. DM itself and Ischaemic Heart Disease (IHD) were the leading causes of excess hospitalisation in 2003, but by 2018, respiratory conditions, cancers and IHD were the most common causes of excess hospitalisation across men and women. Hospitalisation rates declined in almost all traditional DM complication groupings (IHD, stroke, DM, amputations) whilst generally increasing across broader conditions (cancers, infections, respiratory conditions). These differing trends resulted in a diversification in the cause of hospitalisation, such that the traditional DM complications accounted for more than 50% of hospitalisations in 2003, but only approximately 30% in 2018. In contrast, the portion of hospitalisations that broader conditions accounted for increased including respiratory infections being attributable for 12% of hospitalisations in 2

Journal article

Siegel KR, Gregg EW, Duru OK, Shi L, Mangione CM, Thornton PL, Clauser S, Ali MKet al., 2021, Time to start addressing (and not just describing) the social determinants of diabetes: results from the NEXT-D 2.0 network, BMJ OPEN DIABETES RESEARCH & CARE, Vol: 9

Journal article

Ali MK, Pearson-Stuttard J, Selvin E, Gregg EWet al., 2021, Interpreting global trends in type 2 diabetes complications and mortality, DIABETOLOGIA, Vol: 65, Pages: 3-13, ISSN: 0012-186X

Journal article

Laxy M, Zhang P, Benoit SR, Imperatore G, Cheng YJ, Gregg EW, Yang S, Shao Het al., 2021, Trends in Total and Out-of-pocket Payments for Insulin Among Privately Insured US Adults With Diabetes From 2005 to 2018, DIABETES CARE, Vol: 44, Pages: E180-E182, ISSN: 0149-5992

Journal article

Davis K, Perez-Guzman P, Hoyer A, Brinks R, Gregg E, Althoff KN, Justice AC, Reiss P, Gregson S, Smit Met al., 2021, Correction to: Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies., BMC Medicine, Vol: 19, Pages: 228-228, ISSN: 1741-7015

Journal article

Pearson-Stuttard J, Buckley J, Cicek M, Gregg EWet al., 2021, The changing nature of mortality and morbidity in patients with diabetes, Endocrinology and Metabolism Clinics of North America, Vol: 50, Pages: 357-368, ISSN: 0889-8529

Journal article

Holman N, Knighton P, O'Keefe J, Wild SH, Brewster S, Price H, Patel K, Hanif W, Patel V, Gregg EW, Holt RIG, Gadsby R, Khunti K, Valabhji J, Young B, Sattar Net al., 2021, Completion of annual diabetes care processes and mortality: A cohort study using the National Diabetes Audit for England and Wales, DIABETES OBESITY & METABOLISM, Vol: 23, Pages: 2728-2740, ISSN: 1462-8902

Journal article

Gregg EW, Sophiea MK, Weldegiorgis M, 2021, Diabetes and COVID-19: Population Impact 18 Months Into the Pandemic, DIABETES CARE, Vol: 44, Pages: 1916-1923, ISSN: 0149-5992

Journal article

Cicek M, Buckley J, Pearson-Stuttard J, Gregg Eet al., 2021, Characterising multimorbidity from type-2 diabetes: insights from clustering approaches, Endocrinology and Metabolism Clinics of North America, Vol: 50, Pages: 531-558, ISSN: 0889-8529

Patients with type-2 diabetes mellitus (T2DM) often live with and develop multiple co-occurring conditions, namely multimorbidity, with diffuse impacts on clinical care and patient quality of life. However, literature characterising T2DM-related multimorbidity patterns is limited. This review summarises the findings from the emerging literature characterising and quantifying the association of T2DM with multimorbidity clusters. Our findings reveal three dominant cluster types appearing in patients with T2DM-related multimorbidity, such as cardiometabolic precursor conditions, vascular conditions, and mental health conditions. We recommend that holistic patient care centres around early detection of other comorbidities and consideration of wider risk factors, while future research should focus on the temporality of T2DM-related multimorbidity trajectories.

Journal article

Gregg EW, Moin T, 2021, New USPSTF Recommendations for Screening for Prediabetes and Type 2 Diabetes An Opportunity to Create National Momentum, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 326, Pages: 701-703, ISSN: 0098-7484

Journal article

Mercado C, Bullard KM, Gregg EW, Ali MK, Saydah SH, Imperatore Get al., 2021, Differences in US Rural-Urban Trends in Diabetes ABCS, 1999-2018, DIABETES CARE, Vol: 44, Pages: 1766-1773, ISSN: 0149-5992

Journal article

Gong Q, Zhang P, Wang J, Gregg EW, Cheng YJ, Li G, Bennett PHet al., 2021, Efficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study, DIABETES OBESITY & METABOLISM, Vol: 23, Pages: 2385-2394, ISSN: 1462-8902

Journal article

Wadden TA, Chao AM, Anderson H, Annis K, Atkinson K, Bolin P, Brantley P, Clark JM, Coday M, Dutton G, Foreyt JP, Gregg EW, Hazuda HP, Hill JO, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Korytkowski M, Lewis CE, Laferrere B, Middelbeek RJ, Munshi MN, Nathan DM, Neiberg RH, Pilla SJ, Peters A, Pi-Sunyer X, Rejeski JW, Redmon B, Stewart T, Vaughan E, Wagenknecht LE, Walkup MP, Wing RR, Wyatt H, Yanovski SZ, Zhang Pet al., 2021, Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention, OBESITY, Vol: 29, Pages: 1294-1308, ISSN: 1930-7381

Journal article

Holman N, Knighton P, Wild SH, Sattar N, Dew C, Gregg EW, Khunti K, Valabhji J, Young Bet al., 2021, Cohort profile: National Diabetes Audit for England and Wales, DIABETIC MEDICINE, Vol: 38, ISSN: 0742-3071

Journal article

Chan JCN, Lim L-L, Shaw JE, Aguilar-Salinas CA, Gregg EWet al., 2021, Data on diabetes-specific distress are needed to improve the quality of diabetes care reply, LANCET, Vol: 397, Pages: 2150-2150, ISSN: 0140-6736

Journal article

Mora-Diaz JC, Pineyro PE, Rauh R, Nelson W, Sankoh Z, Gregg E, Antonio Carrillo-Avila J, Shen H, Nelli RK, Zimmerman JJ, Gimenez-Lirola LGet al., 2021, Porcine Hemagglutinating Encephalomyelitis Virus Infection In Vivo and Ex Vivo, JOURNAL OF VIROLOGY, Vol: 95, ISSN: 0022-538X

Journal article

Davis K, Perez Guzman P, Hoyer A, Brinks R, Gregg E, Althoff KN, Justice AC, Reiss P, Gregson S, Smit Met al., 2021, Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies, BMC Medicine, Vol: 19, ISSN: 1741-7015

Background:Improved access to effective antiretroviral therapy has meant that people living with HIV (PLHIV) are surviving to older ages. However, PLHIV may be ageing differently to HIV-negative individuals, with dissimilar burdens of non-communicable diseases, such as hypertension. While some observational studies have reported a higher risk of prevalent hypertension among PLHIV compared to HIV-negative individuals, others have found a reduced burden. To clarify the relationship between HIV and hypertension, we identified observational studies and pooled their results to assess whether there is a difference in hypertension risk by HIV status.Methods:We performed a global systematic review and meta-analysis of published cross-sectional studies that examined hypertension risk by HIV status among adults aged > 15 (PROSPERO: CRD42019151359). We searched MEDLINE, EMBASE, Global Health and Cochrane CENTRAL to August 23, 2020, and checked reference lists of included articles. Our main outcome was the risk ratio for prevalent hypertension in PLHIV compared to HIV-negative individuals. Summary estimates were pooled with a random effects model and meta-regression explored whether any difference was associated with study-level factors.Results:Of 21,527 identified studies, 59 were eligible (11,101,581 participants). Crude global hypertension risk was lower among PLHIV than HIV-negative individuals (risk ratio 0.90, 95% CI 0.85–0.96), although heterogeneity between studies was high (I2 = 97%, p < 0.0001). The relationship varied by continent, with risk higher among PLHIV in North America (1.12, 1.02–1.23) and lower among PLHIV in Africa (0.75, 0.68–0.83) and Asia (0.77, 0.63–0.95). Meta-regression revealed strong evidence of a difference in risk ratios when comparing North American and European studies to African ones (North America 1.45, 1.21–1.74; Europe 1.20, 1.03–1.40).Conclusions:Our findings suggest that the r

Journal article

Shao H, Laxy M, Benoit SR, Cheng YJ, Gregg EW, Zhang Pet al., 2021, Trends in Total and Out-of-pocket Payments for Noninsulin Glucose-Lowering Drugs Among US Adults With Large-Employer Private Health Insurance From 2005 to 2018, DIABETES CARE, Vol: 44, Pages: 925-934, ISSN: 0149-5992

Journal article

Bardenheier BH, Wu W-C, Zullo AR, Gravenstein S, Gregg EWet al., 2021, Progression to diabetes by baseline glycemic status among middle-aged and older adults in the United States, 2006-2014, DIABETES RESEARCH AND CLINICAL PRACTICE, Vol: 174, ISSN: 0168-8227

Journal article

Magliano DJ, Chen L, Islam RM, Carstensen B, Gregg EW, Pavkov ME, Andes LJ, Balicer R, Baviera M, Boersma-van Dam E, Booth GL, Chan JCN, Chua YX, Fosse-Edorh S, Fuentes S, Gulseth HL, Gurevicius R, Ha KH, Hird TR, Jermendy G, Khalangot MD, Kim DJ, Kiss Z, Kravchenko V, Leventer-Roberts M, Lin C-Y, Luk AOY, Mata-Cases M, Mauricio D, Nichols GA, Nielen MM, Pang D, Paul SK, Pelletier C, Pildava S, Porath A, Read SH, Roncaglioni MC, Ruiz PL-D, Shestakova M, Vikulova O, Wang K-L, Wild SH, Yekutiel N, Shaw JEet al., 2021, Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings, LANCET DIABETES & ENDOCRINOLOGY, Vol: 9, Pages: 203-211, ISSN: 2213-8587

Journal article

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