Imperial College London
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DrEdwardHarding

Faculty of Natural Sciences, Department of Life Sciences

Visiting Researcher
 
 
 
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Contact

 

e.harding11

 
 
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Location

 

401Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yu:2019:sleep/zsz031,
author = {Yu, X and Ma, Y and Harding, E and Yustos, R and Vyssotski, A and Franks, N and Wisden, W},
doi = {sleep/zsz031},
journal = {Sleep},
pages = {1--13},
title = {Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness},
url = {http://dx.doi.org/10.1093/sleep/zsz031},
volume = {42},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start of the lights-off period, when they remained sleepier. The amount of time spent in NREM sleep and in the wake state in mice with lesioned HA neurons was unchanged over 24 hr, but the sleep–wake cycle was more fragmented. Both the delayed increase in wakefulness at the start of the night and the sleep–wake fragmentation are similar phenotypes to histidine decarboxylase knockout mice, which cannot synthesize HA. Chronic loss of HA neurons did not affect sleep homeostasis after sleep deprivation. However, the chronic loss of HA neurons or chemogenetic inhibition of HA neurons did notably reduce the ability of the wake-promoting compound modafinil to sustain wakefulness. Thus, part of modafinil’s wake-promoting actions arise through the HA system.
AU  - Yu,X
AU  - Ma,Y
AU  - Harding,E
AU  - Yustos,R
AU  - Vyssotski,A
AU  - Franks,N
AU  - Wisden,W
DO  - sleep/zsz031
EP  - 13
PY  - 2019///
SN  - 0161-8105
SP  - 1
TI  - Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness
T2  - Sleep
UR  - http://dx.doi.org/10.1093/sleep/zsz031
UR  - https://academic.oup.com/sleep/article/42/5/zsz031/5307017
UR  - http://hdl.handle.net/10044/1/67232
VL  - 42
ER  -
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