Imperial College London
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DrEdwardHarding

Faculty of Natural Sciences, Department of Life Sciences

Visiting Researcher
 
 
 
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Contact

 

e.harding11

 
 
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Location

 

401Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2015:10.1038/nn.3957,
author = {Zhang, Z and Ferretti, V and Guentan, I and Moro, A and Steinberg, EA and Ye, Z and Zecharia, AY and Yu, X and Vyssotski, AL and Brickley, SG and Yustos, R and Pillidge, ZE and Harding, EC and Wisden, W and Franks, NP},
doi = {10.1038/nn.3957},
journal = {Nature Neuroscience},
pages = {553--561},
title = {Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha(2) adrenergic agonists},
url = {http://dx.doi.org/10.1038/nn.3957},
volume = {18},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Do sedatives engage natural sleep pathways? It is usually assumed that anesthetic-induced sedation and loss of righting reflex (LORR) arise by influencing the same circuitry to lesser or greater extents. For the α2 adrenergic receptor agonist dexmedetomidine, we found that sedation and LORR were in fact distinct states, requiring different brain areas: the preoptic hypothalamic area and locus coeruleus (LC), respectively. Selective knockdown of α2A adrenergic receptors from the LC abolished dexmedetomidine-induced LORR, but not sedation. Instead, we found that dexmedetomidine-induced sedation resembled the deep recovery sleep that follows sleep deprivation. We used TetTag pharmacogenetics in mice to functionally mark neurons activated in the preoptic hypothalamus during dexmedetomidine-induced sedation or recovery sleep. The neuronal ensembles could then be selectively reactivated. In both cases, non-rapid eye movement sleep, with the accompanying drop in body temperature, was recapitulated. Thus, α2 adrenergic receptor–induced sedation and recovery sleep share hypothalamic circuitry sufficient for producing these behavioral states.
AU  - Zhang,Z
AU  - Ferretti,V
AU  - Guentan,I
AU  - Moro,A
AU  - Steinberg,EA
AU  - Ye,Z
AU  - Zecharia,AY
AU  - Yu,X
AU  - Vyssotski,AL
AU  - Brickley,SG
AU  - Yustos,R
AU  - Pillidge,ZE
AU  - Harding,EC
AU  - Wisden,W
AU  - Franks,NP
DO  - 10.1038/nn.3957
EP  - 561
PY  - 2015///
SN  - 1546-1726
SP  - 553
TI  - Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha(2) adrenergic agonists
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/nn.3957
UR  - https://www.nature.com/articles/nn.3957
VL  - 18
ER  -
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