Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Structural Matrix Biology



+44 (0)20 7594 7701e.hohenester




406Sir Ernst Chain BuildingSouth Kensington Campus





Erhard Hohenester is a structural biologist investigating the biosynthesis, assembly and function of extracellular matrix. He is best known for his work on laminins – huge glycoproteins that are essential for the formation and function of basement membranes. His current research focuses on the enzymes involved in glycosaminoglycan biosynthesis (BBSRC-funded collaboration with Ben Schumann at the Francis Crick Institute). Erhard trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. He was promoted to Professor in 2009. He has served the Department of Life Sciences in senior management roles: Deputy Head (2016-2019), Director of Research (from 2020).

Selected Publications

Journal Articles

Hohenester E, 2019, Structural biology of laminins, Essays in Biochemistry, Vol:63, ISSN:0071-1365, Pages:285-295

Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3

Pulido D, Hussain S, Hohenester E, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, Vol:25, ISSN:1878-4186, Pages:530-535

Briggs DC, Yoshida-Moriguchi T, Zheng T, et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4469, Pages:810-814

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