Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Structural Matrix Biology



+44 (0)20 7594 7701e.hohenester




406Sir Ernst Chain BuildingSouth Kensington Campus





Erhard Hohenester is a structural biologist investigating the biosynthesis, assembly and function of extracellular matrix. He is best known for his work on laminins – huge glycoproteins that are essential for the formation and function of basement membranes in all animals. Erhard trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel (Switzerland) in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. He was promoted to Professor in 2009.

Selected Publications

Journal Articles

Hohenester E, 2019, Laminin G-like domains: dystroglycan-specific lectins, Current Opinion in Structural Biology, Vol:56, ISSN:0959-440X, Pages:56-63

Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3

Pulido D, Hussain S, Hohenester E, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, Vol:25, ISSN:1878-4186, Pages:530-535

Briggs DC, Yoshida-Moriguchi T, Zheng T, et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4469, Pages:810-814

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