Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Professor of Structural Matrix Biology







404ASir Ernst Chain BuildingSouth Kensington Campus





Erhard Hohenester is a structural biologist investigating the assembly, structure, and function of extracellular matrix. He is known for his work on laminins – huge proteins that are a key component of all basement membranes. His latest research focused on the enzymes in glycosaminoglycan biosynthesis. Erhard trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel (Switzerland) in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. He currently is Director of Research in the Department of Life Sciences.

Selected Publications

Journal Articles

Sammon D, Krueger A, Busse-Wicher M, et al., 2023, Molecular mechanism of decision-making in glycosaminoglycan biosynthesis, Nature Communications, Vol:14, ISSN:2041-1723

Sammon D, Hohenester E, Leitinger B, 2020, Two-step release of kinase autoinhibition in discoidin domain receptor 1, Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:22051-22060

Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3

Pulido D, Hussain S, Hohenester E, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, Vol:25, ISSN:1878-4186, Pages:530-535

Briggs DC, Yoshida-Moriguchi T, Zheng T, et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4469, Pages:810-814

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