Erhard Hohenester is a structural biologist investigating the assembly, structure, and function of extracellular matrix. He is known for his work on laminins – huge proteins that are a key component of all basement membranes. His latest research focused on the enzymes in glycosaminoglycan biosynthesis. Erhard trained as a chemist in his native Austria and received his PhD in Biophysics from the University of Basel (Switzerland) in 1995. He joined Imperial College London in 1998 with a Wellcome Trust Senior Research Fellowship, which he held for 15 years. He currently is Director of Research in the Department of Life Sciences.
et al., 2023, Molecular mechanism of decision-making in glycosaminoglycan biosynthesis, Nature Communications, Vol:14, ISSN:2041-1723
Sammon D, Hohenester E, Leitinger B, 2020, Two-step release of kinase autoinhibition in discoidin domain receptor 1, Proceedings of the National Academy of Sciences of the United States of America, Vol:117, ISSN:0027-8424, Pages:22051-22060
Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1., Structure, Vol:26, ISSN:0969-2126, Pages:801-809.e3
Pulido D, Hussain S, Hohenester E, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, Vol:25, ISSN:1878-4186, Pages:530-535
et al., 2016, Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology, Vol:12, ISSN:1552-4469, Pages:810-814