Imperial College London
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Dr. Elita Jauneikaite

Faculty of Medicine, School of Public Health

Advanced Research Fellow
 
 
 
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Contact

 

e.jauneikaite

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jauneikaite:2021:10.1016/j.jinf.2021.08.040,
author = {Jauneikaite, E and Pichon, B and Mosavie, M and Fallowfield, JL and Davey, T and Thorpe, N and Nelstrop, A and Sriskandan, S and Lamb, LE},
doi = {10.1016/j.jinf.2021.08.040},
journal = {Journal of Infection},
title = {Staphylococcus argenteus transmission among healthy Royal Marines: a molecular epidemiology case-study},
url = {http://dx.doi.org/10.1016/j.jinf.2021.08.040},
volume = {83},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: During a prospective study of S. aureus carriage in Royal Marines recruits, six S. argenteus strains were identified in four recruits. As S. argenteus sepsis leads to mortality similar to S. aureus, we determined the potential for within same troop transmission, to evaluate future outbreak risk.Methods: We used whole-genome sequencing to characterise S. argenteus and investigate phylogenetic relationships between isolates.Results: S. argenteus strains (t5078, ST2250) were detected in 4/40 recruits in the same troop (training cohort) in weeks 1, 6 or 15 of training. No mec, tsst or LukPV genes were detected. We identified differences of 1-17 core SNPs between S. argenteus from different recruits. In two recruits, two S. argenteus strains were isolated; these could be distinguished by 2 and 15 core SNPs.Conclusions: The identification of S. argenteus within a single troop from the total recruit population suggests a common source for transmission, though high number of SNPs were identified, both within-host and within-cluster. The high number of SNPs between some isolates may indicate a common source of diverse isolates or a high level of S. argenteus mutation in carriage. S. argenteus is newly recognised species; and understanding of the frequency of genetic changes during transmission and transition from asymptomatic carriage to disease is required.
AU  - Jauneikaite,E
AU  - Pichon,B
AU  - Mosavie,M
AU  - Fallowfield,JL
AU  - Davey,T
AU  - Thorpe,N
AU  - Nelstrop,A
AU  - Sriskandan,S
AU  - Lamb,LE
DO  - 10.1016/j.jinf.2021.08.040
PY  - 2021///
SN  - 0163-4453
TI  - Staphylococcus argenteus transmission among healthy Royal Marines: a molecular epidemiology case-study
T2  - Journal of Infection
UR  - http://dx.doi.org/10.1016/j.jinf.2021.08.040
UR  - https://www.sciencedirect.com/science/article/pii/S0163445321004448?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91480
VL  - 83
ER  -
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