Imperial College London
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Dr. Elita Jauneikaite

Faculty of Medicine, School of Public Health

Advanced Research Fellow
 
 
 
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Contact

 

e.jauneikaite

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jauneikaite:2022:jac/dkac071,
author = {Jauneikaite, E and Honeyford, K and Blandy, O and Mosavie, M and Pearson, M and Ramzan, FA and Ellington, M and PARKHILL, J and Costelloe, C and Woodford, N and Sriskandan, S},
doi = {jac/dkac071},
journal = {Journal of Antimicrobial Chemotherapy},
pages = {1753--1761},
title = {Bacterial genotypic and patient risk factors for adverse outcomes in Escherichia coli bloodstream infections: a prospective molecular-epidemiological study},
url = {http://dx.doi.org/10.1093/jac/dkac071},
volume = {77},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives:Escherichia coli bloodstream infections have shown a sustained increase in England, for reasons that are unknown. Furthermore, the contribution of multi-drug resistant lineages such as ST131 to overall E. coli disease burden and outcome is undetermined. Methods:We genome sequenced E. coli blood isolates from all patients with E. coli bacteraemia in north-west London from July 2015 to August 2016 and assigned multi-locus sequence types, virulence factors, and AMR genes to all isolates. Isolate sequence types were then linked to phenotypic antimicrobial susceptibility, patient demographic, and clinical outcome data to explore relationships between the E. coli sequence types, patient factors, and outcomes. Results:A total of 551 E. coli genomes were analysed.   Four sequence types (ST131, 21.2%; ST73, 14.5%; ST69, 9.3%; and ST95, 8.2%) accounted for over half of cases.  E. coli genotype ST131-C2 was associated with phenotypic non-susceptibility to quinolones, third-generation cephalosporins, amoxicillin, amoxicillin-clavulanic acid, gentamicin, and trimethoprim. Among 300 patients from whom outcome was known, an association between the ST131-C2 lineage and longer length-of-stay was detected, although multivariable regression modelling did not demonstrate an association between E. coli sequence type and mortality. Several unexpected associations were identified between gentamicin non-susceptibility; ethnicity; sex and adverse outcomes, requiring further research.Conclusions:Although E. coli sequence type was associated with defined antimicrobial non-susceptibility patterns and prolonged length-of-stay, E. coli sequence type was not associated with increased mortality. ST131 has outcompeted other lineages in north-west London. Where ST131 is prevalent, caution is required when devising empiric regimens for suspected Gram-negative sepsis, in particular the pairing of beta-lactam agents with gentamicin.
AU  - Jauneikaite,E
AU  - Honeyford,K
AU  - Blandy,O
AU  - Mosavie,M
AU  - Pearson,M
AU  - Ramzan,FA
AU  - Ellington,M
AU  - PARKHILL,J
AU  - Costelloe,C
AU  - Woodford,N
AU  - Sriskandan,S
DO  - jac/dkac071
EP  - 1761
PY  - 2022///
SN  - 0305-7453
SP  - 1753
TI  - Bacterial genotypic and patient risk factors for adverse outcomes in Escherichia coli bloodstream infections: a prospective molecular-epidemiological study
T2  - Journal of Antimicrobial Chemotherapy
UR  - http://dx.doi.org/10.1093/jac/dkac071
UR  - https://academic.oup.com/jac/article/77/6/1753/6546015
UR  - http://hdl.handle.net/10044/1/95266
VL  - 77
ER  -
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