Imperial College London
Alternate

Dr Elaina Maginn

Faculty of Medicine, Faculty of Medicine Centre

Senior Teaching Fellow
 
 
 
//

Contact

 

e.maginn

 
 
//

Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dungl:2015:10.3389/fonc.2015.00240,
author = {Dungl, DA and Maginn, EN and Stronach, EA},
doi = {10.3389/fonc.2015.00240},
journal = {Frontiers in Oncology},
title = {Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy.},
url = {http://dx.doi.org/10.3389/fonc.2015.00240},
volume = {5},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Platinum-based chemotherapy is the cornerstone of ovarian cancer treatment, and its efficacy is dependent on the generation of DNA damage, with subsequent induction of apoptosis. Inappropriate or aberrant activation of the DNA damage response network is associated with resistance to platinum, and defects in DNA repair pathways play critical roles in determining patient response to chemotherapy. In ovarian cancer, tumor cell defects in homologous recombination - a repair pathway activated in response to double-strand DNA breaks (DSB) - are most commonly associated with platinum-sensitive disease. However, despite initial sensitivity, the emergence of resistance is frequent. Here, we review strategies for directly interfering with DNA repair pathways, with particular focus on direct inhibition of non-homologous end joining (NHEJ), another DSB repair pathway. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a core component of NHEJ and it has shown considerable promise as a chemosensitization target in numerous cancer types, including ovarian cancer where it functions to promote platinum-induced survival signaling, via AKT activation. The development of pharmacological inhibitors of DNA-PKcs is on-going, and clinic-ready agents offer real hope to patients with chemoresistant disease.
AU  - Dungl,DA
AU  - Maginn,EN
AU  - Stronach,EA
DO  - 10.3389/fonc.2015.00240
PY  - 2015///
SN  - 2234-943X
TI  - Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy.
T2  - Frontiers in Oncology
UR  - http://dx.doi.org/10.3389/fonc.2015.00240
UR  - http://hdl.handle.net/10044/1/28051
VL  - 5
ER  -
Download