Imperial College London
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Erik Mayer

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Urology
 
 
 
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Contact

 

e.mayer Website

 
 
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Location

 

1020Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kowa:2021:10.1259/bjr.20201423,
author = {Kowa, J-Y and Soneji, N and Sohaib, SA and Mayer, E and Hazell, S and Butterfield, N and Shur, J and Ap, Dafydd D},
doi = {10.1259/bjr.20201423},
journal = {British Journal of Radiology},
pages = {1--10},
title = {Detection and staging of radio-recurrent prostate cancer using multiparametric MRI.},
url = {http://dx.doi.org/10.1259/bjr.20201423},
volume = {94},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: We determined the sensitivity and specificity of multiparametric magnetic resonance imaging (MP-MRI) in detection of locally recurrent prostate cancer and extra prostatic extension in the post-radical radiotherapy setting. Histopathological reference standard was whole-mount prostatectomy specimens. We also assessed for any added value of the dynamic contrast enhancement (DCE) sequence in detection and staging of local recurrence. METHODS: This was a single centre retrospective study. Participants were selected from a database of males treated with salvage prostatectomy for locally recurrent prostate cancer following radiotherapy. All underwent pre-operative prostate-specific antigen assay, positron emission tomography CT, MP-MRI and transperineal template prostate mapping biopsy prior to salvage prostatectomy. MP-MRI performance was assessed using both Prostate Imaging-Reporting and Data System v. 2 and a modified scoring system for the post-treatment setting. RESULTS: 24 patients were enrolled. Using Prostate Imaging-Reporting and Data System v. 2, sensitivity, specificity, positive predictive value and negative predictive value was 64%, 94%, 98% and 36%. MP-MRI under staged recurrent cancer in 63%. A modified scoring system in which DCE was used as a co-dominant sequence resulted in improved diagnostic sensitivity (61%-76%) following subgroup analysis. CONCLUSION: Our results show MP-MRI has moderate sensitivity (64%) and high specificity (94%) in detecting radio-recurrent intraprostatic disease, though disease tends to be under quantified and under staged. Greater emphasis on dynamic contrast images in overall scoring can improve diagnostic sensitivity. ADVANCES IN KNOWLEDGE: MP-MRI tends to under quantify and under stage radio-recurrent prostate cancer. DCE has a potentially augmented role in detecting recurrent tumour compared with the de novo setting. This has relevance in the event of any future modified MP-MRI scoring system for the irradiated gl
AU  - Kowa,J-Y
AU  - Soneji,N
AU  - Sohaib,SA
AU  - Mayer,E
AU  - Hazell,S
AU  - Butterfield,N
AU  - Shur,J
AU  - Ap,Dafydd D
DO  - 10.1259/bjr.20201423
EP  - 10
PY  - 2021///
SN  - 0007-1285
SP  - 1
TI  - Detection and staging of radio-recurrent prostate cancer using multiparametric MRI.
T2  - British Journal of Radiology
UR  - http://dx.doi.org/10.1259/bjr.20201423
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33586998
UR  - https://www.birpublications.org/doi/10.1259/bjr.20201423
UR  - http://hdl.handle.net/10044/1/87166
VL  - 94
ER  -
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