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@article{Savvopoulos:2015,
author = {Savvopoulos, SV and Misener, R and Panoskaltsis, N and Pistikopoulos, EN and Mantalaris, A},
journal = {Computer Aided Chemical Engineering},
title = {Global Sensitivity Analysis for a Dynamic Model of Chronic Lymphocytic Leukemia Disease Trajectories},
year = {2015}
}

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TY  - JOUR
AB  - This paper implements global sensitivity analysis in the Savvopoulos et al. (2014) mathematical model of B cell chronic lymphocytic leukaemia (B-CLL); this dynamic model represents a frame- work for modelling dynamic B-CLL trajectories. B-CLL is a heterogeneous, slowly-progressing disease where a type of white blood cell, B lymphocytes, accumulates in bone marrow, peripheral blood, lymph nodes and spleen. The Savvopoulos et al. (2014) modelling framework integrates both temporal and spatial disease aspects; delay differential equations capture latency in the cell proliferation cycle and population balance equations between disease centres represent inter-tissue B-CLL migration. This manuscript conducts global sensitivity analysis using the random sampling - high dimensional mathematical representation (RS-HDMR) method to: (1) uncover which are the most critical model parameters; (2) analyse the system of model equations; (3) provide clinically-relevant patient testing recommendations leading to effective model parametrisations.
AU  - Savvopoulos,SV
AU  - Misener,R
AU  - Panoskaltsis,N
AU  - Pistikopoulos,EN
AU  - Mantalaris,A
PY  - 2015///
SN  - 1570-7946
TI  - Global Sensitivity Analysis for a Dynamic Model of Chronic Lymphocytic Leukemia Disease Trajectories
T2  - Computer Aided Chemical Engineering
ER  -

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