Imperial College London
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DrEmmaRansome

Faculty of Natural Sciences, Department of Life Sciences

Lecturer
 
 
 
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Contact

 

e.ransome

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hartmann:2017:10.1073/pnas.1710248114,
author = {Hartmann, AC and Petras, D and Quinn, RA and Protsyuk, I and Archer, FI and Ransome, E and Williams, GJ and Bailey, BA and Vermeij, MJA and Alexandrov, T and Dorrestein, PC and Rohwer, FL},
doi = {10.1073/pnas.1710248114},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {11685--11690},
title = {Meta-mass shift chemical profiling of metabolomes from coral reefs},
url = {http://dx.doi.org/10.1073/pnas.1710248114},
volume = {114},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabolome-wide relationships between molecules and the putative chemical groups that differentiate them (e.g., H2, CH2, COCH2). MeMSChem profiling was used to analyze a publicly available metabolomic dataset of coral, algal, and fungal mat holobionts (i.e., the host and its associated microbes and viruses) sampled from some of Earth’s most remote and pristine coral reefs. Each type of holobiont had distinct mass shift profiles, even when the analysis was restricted to molecules found in all samples. This result suggests that holobionts modify the same molecules in different ways and offers insights into the generation of molecular diversity. Three genera of stony corals had distinct patterns of molecular relatedness despite their high degree of taxonomic relatedness. MeMSChem profiles also partially differentiated between individuals, suggesting that every coral reef holobiont is a potential source of novel chemical diversity.
AU  - Hartmann,AC
AU  - Petras,D
AU  - Quinn,RA
AU  - Protsyuk,I
AU  - Archer,FI
AU  - Ransome,E
AU  - Williams,GJ
AU  - Bailey,BA
AU  - Vermeij,MJA
AU  - Alexandrov,T
AU  - Dorrestein,PC
AU  - Rohwer,FL
DO  - 10.1073/pnas.1710248114
EP  - 11690
PY  - 2017///
SN  - 0027-8424
SP  - 11685
TI  - Meta-mass shift chemical profiling of metabolomes from coral reefs
T2  - Proceedings of the National Academy of Sciences of the United States of America
UR  - http://dx.doi.org/10.1073/pnas.1710248114
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000414127400058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.pnas.org/content/114/44/11685/
VL  - 114
ER  -
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