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@article{Naudin:2020:10.1007/s10654-019-00559-6,
author = {Naudin, S and Viallon, V and Hashim, D and Freisling, H and Jenab, M and Weiderpass, E and Perrier, F and McKenzie, F and Bueno-de-Mesquita, HB and Olsen, A and Tjønneland, A and Dahm, CC and Overvad, K and Mancini, FR and Rebours, V and Boutron-Ruault, M-C and Katzke, V and Kaaks, R and Bergmann, M and Boeing, H and Peppa, E and Karakatsani, A and Trichopoulou, A and Pala, V and Masala, G and Panico, S and Tumino, R and Sacerdote, C and May, AM and van, Gils CH and Rylander, C and Borch, KB and Chirlaque, López MD and Sánchez, M-J and Ardanaz, E and Quirós, JR and Amiano, Exezarreta P and Sund, M and Drake, I and Regnér, S and Travis, RC and Wareham, N and Aune, D and Riboli, E and Gunter, MJ and Duell, EJ and Brennan, P and Ferrari, P},
doi = {10.1007/s10654-019-00559-6},
journal = {European Journal of Epidemiology},
pages = {975--986},
title = {Healthy lifestyle and the risk of pancreatic cancer in the EPIC study},
url = {http://dx.doi.org/10.1007/s10654-019-00559-6},
volume = {35},
year = {2020}
}

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TY  - JOUR
AB  - Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants' shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e-09) and 0.77 (0.72, 0.82; ptrend = 1.7e-15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e-04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.
AU  - Naudin,S
AU  - Viallon,V
AU  - Hashim,D
AU  - Freisling,H
AU  - Jenab,M
AU  - Weiderpass,E
AU  - Perrier,F
AU  - McKenzie,F
AU  - Bueno-de-Mesquita,HB
AU  - Olsen,A
AU  - Tjønneland,A
AU  - Dahm,CC
AU  - Overvad,K
AU  - Mancini,FR
AU  - Rebours,V
AU  - Boutron-Ruault,M-C
AU  - Katzke,V
AU  - Kaaks,R
AU  - Bergmann,M
AU  - Boeing,H
AU  - Peppa,E
AU  - Karakatsani,A
AU  - Trichopoulou,A
AU  - Pala,V
AU  - Masala,G
AU  - Panico,S
AU  - Tumino,R
AU  - Sacerdote,C
AU  - May,AM
AU  - van,Gils CH
AU  - Rylander,C
AU  - Borch,KB
AU  - Chirlaque,López MD
AU  - Sánchez,M-J
AU  - Ardanaz,E
AU  - Quirós,JR
AU  - Amiano,Exezarreta P
AU  - Sund,M
AU  - Drake,I
AU  - Regnér,S
AU  - Travis,RC
AU  - Wareham,N
AU  - Aune,D
AU  - Riboli,E
AU  - Gunter,MJ
AU  - Duell,EJ
AU  - Brennan,P
AU  - Ferrari,P
DO  - 10.1007/s10654-019-00559-6
EP  - 986
PY  - 2020///
SN  - 0393-2990
SP  - 975
TI  - Healthy lifestyle and the risk of pancreatic cancer in the EPIC study
T2  - European Journal of Epidemiology
UR  - http://dx.doi.org/10.1007/s10654-019-00559-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31564045
UR  - http://hdl.handle.net/10044/1/75204
VL  - 35
ER  -

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